In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine
This research was conducted to investigate if there is a relation between insulin resistance incidence and inhibition of interferon gamma production or not. Firstly, insulin resistance was induced by high fat diet (HFD) intake for 6 weeks. Secondly, berberine was used as protective/curative compound...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2016-01, Vol.2016 (2016), p.1-7 |
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| creator | Elshehawy, Ashraf Abdelhamed Sahyoun, Heba Abdelghany Ghareeb, Doaa A. Mahmoud, Mohammad Ahmad Elsayed, Mohammad Mohammad |
| description | This research was conducted to investigate if there is a relation between insulin resistance incidence and inhibition of interferon gamma production or not. Firstly, insulin resistance was induced by high fat diet (HFD) intake for 6 weeks. Secondly, berberine was used as protective/curative compound for insulin resistance. Results revealed that feeding rats HFD for 6 weeks developed features of insulin resistance (IR) syndrome. These features presented in increased body weight, hyperglycemia, hyperinsulinemia, hypercholesterolemia (with increased LDL-cholesterol and decreased HDL-cholesterol), and hypertriglyceridemia. Level of antioxidant enzymes in HFD group was higher than in normal one. Also there was an increasing in level of proinflammatory cytokines as interleukin- (IL-) 6 and IL-12 in HFD group. Feeding rats HFD for 6 weeks also decreased level of interferon gamma (IFN-γ). The decreased level of IFN-γ has been shown to predict infection with infectious diseases especially viral infection. Treatment and protection with berberine 50 mg/kg/day for 2 weeks were found to be effective against the features of insulin resistance syndrome, improved levels of insulin resistance parameters, lipid profile, antioxidant enzymes, proinflammatory cytokines, and IFN-γ. |
| doi_str_mv | 10.1155/2016/2039897 |
| format | Article |
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Firstly, insulin resistance was induced by high fat diet (HFD) intake for 6 weeks. Secondly, berberine was used as protective/curative compound for insulin resistance. Results revealed that feeding rats HFD for 6 weeks developed features of insulin resistance (IR) syndrome. These features presented in increased body weight, hyperglycemia, hyperinsulinemia, hypercholesterolemia (with increased LDL-cholesterol and decreased HDL-cholesterol), and hypertriglyceridemia. Level of antioxidant enzymes in HFD group was higher than in normal one. Also there was an increasing in level of proinflammatory cytokines as interleukin- (IL-) 6 and IL-12 in HFD group. Feeding rats HFD for 6 weeks also decreased level of interferon gamma (IFN-γ). The decreased level of IFN-γ has been shown to predict infection with infectious diseases especially viral infection. Treatment and protection with berberine 50 mg/kg/day for 2 weeks were found to be effective against the features of insulin resistance syndrome, improved levels of insulin resistance parameters, lipid profile, antioxidant enzymes, proinflammatory cytokines, and IFN-γ.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2016/2039897</identifier><identifier>PMID: 27642351</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Biological response modifiers ; Blood cholesterol ; Body weight ; Enzymes ; Ethylenediaminetetraacetic acid ; Glucose ; Health aspects ; Herbal medicine ; Hypercholesterolemia ; Insulin resistance ; Interferon gamma ; Interleukins ; Kinases ; Low density lipoproteins ; Medical research ; Medicine, Experimental ; Type 2 diabetes ; Viral infections</subject><ispartof>Evidence-based complementary and alternative medicine, 2016-01, Vol.2016 (2016), p.1-7</ispartof><rights>Copyright © 2016 Mohammad Ahmad Mahmoud et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Mohammad Ahmad Mahmoud et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Mohammad Ahmad Mahmoud et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-430d6b71a73b44f0494fd55d22f80d531ea0926a4ddc5a2a0b693327663b8dd63</citedby><cites>FETCH-LOGICAL-c494t-430d6b71a73b44f0494fd55d22f80d531ea0926a4ddc5a2a0b693327663b8dd63</cites><orcidid>0000-0002-7693-1894 ; 0000-0003-3327-4377</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013203/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013203/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27642351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Razzaque, Mohammed S.</contributor><creatorcontrib>Elshehawy, Ashraf Abdelhamed</creatorcontrib><creatorcontrib>Sahyoun, Heba Abdelghany</creatorcontrib><creatorcontrib>Ghareeb, Doaa A.</creatorcontrib><creatorcontrib>Mahmoud, Mohammad Ahmad</creatorcontrib><creatorcontrib>Elsayed, Mohammad Mohammad</creatorcontrib><title>In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>This research was conducted to investigate if there is a relation between insulin resistance incidence and inhibition of interferon gamma production or not. 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Treatment and protection with berberine 50 mg/kg/day for 2 weeks were found to be effective against the features of insulin resistance syndrome, improved levels of insulin resistance parameters, lipid profile, antioxidant enzymes, proinflammatory cytokines, and IFN-γ.</description><subject>Biological response modifiers</subject><subject>Blood cholesterol</subject><subject>Body weight</subject><subject>Enzymes</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Hypercholesterolemia</subject><subject>Insulin resistance</subject><subject>Interferon gamma</subject><subject>Interleukins</subject><subject>Kinases</subject><subject>Low density lipoproteins</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Type 2 diabetes</subject><subject>Viral infections</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNks1rFDEYxgdRbK3ePEvAi1BX850ZD0Jbal0oKFLFW8hM3nRTZpM1mdni3T_cDLOu1VMvyUveXx7ej6eqnhP8hhAh3lJMZDlYUzfqQXVIFCcLTuv64T5W3w-qJznfYEwbpdTj6oAqySkT5LD6tQzom99GtAwDpAS9GXwMeeU3qIXhFiCUTB57H9AXyD4PJnSATLDzBwcpBnRh1muDPqdox276_m6KByjxdmavVpDMBsbBd-jcuZJB0aFTSC0kH-Bp9ciZPsOz3X1Uff1wfnX2cXH56WJ5dnK56HjDhwVn2MpWEaNYy7nD5dFZISylrsZWMAIGN1Qabm0nDDW4lQ1jpVfJ2tpayY6q97PuZmzXYDsIQzK93iS_NumnjsbrfzPBr_R13GqBCSsjLgKvdgIp_hghD3rtcwd9bwLEMWtSM0q5KKu4B0qJqpuaT-jL_9CbOKZQJlEoImVZsLxDXZsetA8ulhK7SVSfSIIZkYLSQr2eqS7FnBO4fXcE68kvevKL3vml4C_uTmQP_zFIAY5nYOWDNbf-nnJQGHDmL10KbARnvwGvRtH3</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Elshehawy, Ashraf Abdelhamed</creator><creator>Sahyoun, Heba Abdelghany</creator><creator>Ghareeb, Doaa A.</creator><creator>Mahmoud, Mohammad Ahmad</creator><creator>Elsayed, Mohammad Mohammad</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7693-1894</orcidid><orcidid>https://orcid.org/0000-0003-3327-4377</orcidid></search><sort><creationdate>20160101</creationdate><title>In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine</title><author>Elshehawy, Ashraf Abdelhamed ; 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Firstly, insulin resistance was induced by high fat diet (HFD) intake for 6 weeks. Secondly, berberine was used as protective/curative compound for insulin resistance. Results revealed that feeding rats HFD for 6 weeks developed features of insulin resistance (IR) syndrome. These features presented in increased body weight, hyperglycemia, hyperinsulinemia, hypercholesterolemia (with increased LDL-cholesterol and decreased HDL-cholesterol), and hypertriglyceridemia. Level of antioxidant enzymes in HFD group was higher than in normal one. Also there was an increasing in level of proinflammatory cytokines as interleukin- (IL-) 6 and IL-12 in HFD group. Feeding rats HFD for 6 weeks also decreased level of interferon gamma (IFN-γ). The decreased level of IFN-γ has been shown to predict infection with infectious diseases especially viral infection. Treatment and protection with berberine 50 mg/kg/day for 2 weeks were found to be effective against the features of insulin resistance syndrome, improved levels of insulin resistance parameters, lipid profile, antioxidant enzymes, proinflammatory cytokines, and IFN-γ.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>27642351</pmid><doi>10.1155/2016/2039897</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7693-1894</orcidid><orcidid>https://orcid.org/0000-0003-3327-4377</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Biological response modifiers Blood cholesterol Body weight Enzymes Ethylenediaminetetraacetic acid Glucose Health aspects Herbal medicine Hypercholesterolemia Insulin resistance Interferon gamma Interleukins Kinases Low density lipoproteins Medical research Medicine, Experimental Type 2 diabetes Viral infections |
| title | In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine |
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