Preclinical Studies of Stem Cell Transplantation in Intracerebral Hemorrhage: a Systemic Review and Meta-Analysis
To comprehensively evaluate the therapeutic effects on both functional and structural outcomes, we performed a meta-analysis of preclinical data on stem cell therapy in intracranial hemorrhage, thus providing optimal evidence and instruction for clinical translation. We searched online databases to...
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| Veröffentlicht in: | Molecular neurobiology 2016-10, Vol.53 (8), p.5269-5277 |
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| creator | Hu, Yang Liu, Na Zhang, Ping Pan, Chao Zhang, Youping Tang, Yingxin Deng, Hong Aimaiti, Miribanu Zhang, Ye Zhou, Houguang Wu, Guofeng Tang, Zhouping |
| description | To comprehensively evaluate the therapeutic effects on both functional and structural outcomes, we performed a meta-analysis of preclinical data on stem cell therapy in intracranial hemorrhage, thus providing optimal evidence and instruction for clinical translation. We searched online databases to identify eligible studies based on unmodified stem cell transplantation in intracranial hemorrhage (ICH). From each study, we extracted data regarding neurobehavioral and histological outcomes in order to analyze the comprehensive effective sizes according to the most important clinical parameters (seven indices) and to explore any potential correlation through meta-regression. We analyzed 40 eligible studies including 1021 animals and found a significant improvement in both behavioral and structural outcomes with the median effect size of 1.77 for modified Neurological Severity Score, 1.16 for the modified placement test, 1.82 for the rotarod test, and 1.24 for tissue loss reduction. The meta-regression results revealed that intracerebral administration was the most effective for behavioral and structural recovery post-ICH; mesenchymal stem cells shared comparable therapeutic effects with neural stem cells. Delayed therapy, applied more than 1 week after ICH, showed the greatest improvement of structural outcomes. Stem cell therapy showed significant improvement on behavioral and structural outcomes of ICH animals with relatively large effect sizes. However, the practical efficacy of the therapy is likely to be lower considering poor study quality and non-negligible publication bias. Further, future research should interpret animal results cautiously considering the limited internal and external validity when referring to the design of both animal studies and clinical trials. |
| doi_str_mv | 10.1007/s12035-015-9441-6 |
| format | Article |
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We searched online databases to identify eligible studies based on unmodified stem cell transplantation in intracranial hemorrhage (ICH). From each study, we extracted data regarding neurobehavioral and histological outcomes in order to analyze the comprehensive effective sizes according to the most important clinical parameters (seven indices) and to explore any potential correlation through meta-regression. We analyzed 40 eligible studies including 1021 animals and found a significant improvement in both behavioral and structural outcomes with the median effect size of 1.77 for modified Neurological Severity Score, 1.16 for the modified placement test, 1.82 for the rotarod test, and 1.24 for tissue loss reduction. The meta-regression results revealed that intracerebral administration was the most effective for behavioral and structural recovery post-ICH; mesenchymal stem cells shared comparable therapeutic effects with neural stem cells. Delayed therapy, applied more than 1 week after ICH, showed the greatest improvement of structural outcomes. Stem cell therapy showed significant improvement on behavioral and structural outcomes of ICH animals with relatively large effect sizes. However, the practical efficacy of the therapy is likely to be lower considering poor study quality and non-negligible publication bias. Further, future research should interpret animal results cautiously considering the limited internal and external validity when referring to the design of both animal studies and clinical trials.</description><identifier>ISSN: 0893-7648</identifier><identifier>EISSN: 1559-1182</identifier><identifier>DOI: 10.1007/s12035-015-9441-6</identifier><identifier>PMID: 26409481</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cerebral Hemorrhage - therapy ; Hemorrhage ; Meta-analysis ; Neurobiology ; Neurology ; Neurosciences ; Publication Bias ; Regression Analysis ; Stem Cell Transplantation ; Stem cells ; Systematic review</subject><ispartof>Molecular neurobiology, 2016-10, Vol.53 (8), p.5269-5277</ispartof><rights>The Author(s) 2015</rights><rights>Springer Science+Business Media New York 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-f03bbd8d3f0b93a93128d64e94b09055152d9701b3edbae7e4ae669c947940f13</citedby><cites>FETCH-LOGICAL-c569t-f03bbd8d3f0b93a93128d64e94b09055152d9701b3edbae7e4ae669c947940f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12035-015-9441-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12035-015-9441-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26409481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Yang</creatorcontrib><creatorcontrib>Liu, Na</creatorcontrib><creatorcontrib>Zhang, Ping</creatorcontrib><creatorcontrib>Pan, Chao</creatorcontrib><creatorcontrib>Zhang, Youping</creatorcontrib><creatorcontrib>Tang, Yingxin</creatorcontrib><creatorcontrib>Deng, Hong</creatorcontrib><creatorcontrib>Aimaiti, Miribanu</creatorcontrib><creatorcontrib>Zhang, Ye</creatorcontrib><creatorcontrib>Zhou, Houguang</creatorcontrib><creatorcontrib>Wu, Guofeng</creatorcontrib><creatorcontrib>Tang, Zhouping</creatorcontrib><title>Preclinical Studies of Stem Cell Transplantation in Intracerebral Hemorrhage: a Systemic Review and Meta-Analysis</title><title>Molecular neurobiology</title><addtitle>Mol Neurobiol</addtitle><addtitle>Mol Neurobiol</addtitle><description>To comprehensively evaluate the therapeutic effects on both functional and structural outcomes, we performed a meta-analysis of preclinical data on stem cell therapy in intracranial hemorrhage, thus providing optimal evidence and instruction for clinical translation. We searched online databases to identify eligible studies based on unmodified stem cell transplantation in intracranial hemorrhage (ICH). From each study, we extracted data regarding neurobehavioral and histological outcomes in order to analyze the comprehensive effective sizes according to the most important clinical parameters (seven indices) and to explore any potential correlation through meta-regression. We analyzed 40 eligible studies including 1021 animals and found a significant improvement in both behavioral and structural outcomes with the median effect size of 1.77 for modified Neurological Severity Score, 1.16 for the modified placement test, 1.82 for the rotarod test, and 1.24 for tissue loss reduction. The meta-regression results revealed that intracerebral administration was the most effective for behavioral and structural recovery post-ICH; mesenchymal stem cells shared comparable therapeutic effects with neural stem cells. Delayed therapy, applied more than 1 week after ICH, showed the greatest improvement of structural outcomes. Stem cell therapy showed significant improvement on behavioral and structural outcomes of ICH animals with relatively large effect sizes. However, the practical efficacy of the therapy is likely to be lower considering poor study quality and non-negligible publication bias. Further, future research should interpret animal results cautiously considering the limited internal and external validity when referring to the design of both animal studies and clinical trials.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cerebral Hemorrhage - therapy</subject><subject>Hemorrhage</subject><subject>Meta-analysis</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Publication Bias</subject><subject>Regression Analysis</subject><subject>Stem Cell Transplantation</subject><subject>Stem cells</subject><subject>Systematic review</subject><issn>0893-7648</issn><issn>1559-1182</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU9v1DAQxS0EotuFD8AFWeLCJeDxn8TmgFStKK1UBKLlbDnJZOsqcbZ2UrTfHq9SqoKExMkjze89z8wj5BWwd8BY9T4BZ0IVDFRhpISifEJWoJQpADR_SlZMG1FUpdRH5DilG8Y4B1Y9J0e8lMxIDSty-y1i0_vgG9fTy2luPSY6drnEgW6w7-lVdCHtehcmN_kxUB_oeZiiazBiHbPqDIcxxmu3xQ_U0ct9ylLf0O945_EndaGlX3ByxUlw_T759II861yf8OX9uyY_Tj9dbc6Ki6-fzzcnF0WjSjMVHRN13epWdKw2whkBXLelRCNrZphSoHhrKga1wLZ2WKF0WJamMbIyknUg1uTj4rub6wHbBg9D93YX_eDi3o7O2z87wV_b7XhnFQMOUmeDt_cGcbydMU128KnJJ3EBxznZfOPKgNAC_gOFSivJtcjom7_Qm3GO-TYLddgsp7YmsFBNHFOK2D3MDcwesrdL9jZnbw_Z2zJrXj9e-EHxO-wM8AVIuRW2GB99_U_XX7-Eulc</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Hu, Yang</creator><creator>Liu, Na</creator><creator>Zhang, Ping</creator><creator>Pan, Chao</creator><creator>Zhang, Youping</creator><creator>Tang, Yingxin</creator><creator>Deng, Hong</creator><creator>Aimaiti, Miribanu</creator><creator>Zhang, Ye</creator><creator>Zhou, Houguang</creator><creator>Wu, Guofeng</creator><creator>Tang, Zhouping</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161001</creationdate><title>Preclinical Studies of Stem Cell Transplantation in Intracerebral Hemorrhage: a Systemic Review and Meta-Analysis</title><author>Hu, Yang ; Liu, Na ; Zhang, Ping ; Pan, Chao ; Zhang, Youping ; Tang, Yingxin ; Deng, Hong ; Aimaiti, Miribanu ; Zhang, Ye ; Zhou, Houguang ; Wu, Guofeng ; Tang, Zhouping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-f03bbd8d3f0b93a93128d64e94b09055152d9701b3edbae7e4ae669c947940f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Cerebral Hemorrhage - therapy</topic><topic>Hemorrhage</topic><topic>Meta-analysis</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Publication Bias</topic><topic>Regression Analysis</topic><topic>Stem Cell Transplantation</topic><topic>Stem cells</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Yang</creatorcontrib><creatorcontrib>Liu, Na</creatorcontrib><creatorcontrib>Zhang, Ping</creatorcontrib><creatorcontrib>Pan, Chao</creatorcontrib><creatorcontrib>Zhang, Youping</creatorcontrib><creatorcontrib>Tang, Yingxin</creatorcontrib><creatorcontrib>Deng, Hong</creatorcontrib><creatorcontrib>Aimaiti, Miribanu</creatorcontrib><creatorcontrib>Zhang, Ye</creatorcontrib><creatorcontrib>Zhou, Houguang</creatorcontrib><creatorcontrib>Wu, Guofeng</creatorcontrib><creatorcontrib>Tang, Zhouping</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Yang</au><au>Liu, Na</au><au>Zhang, Ping</au><au>Pan, Chao</au><au>Zhang, Youping</au><au>Tang, Yingxin</au><au>Deng, Hong</au><au>Aimaiti, Miribanu</au><au>Zhang, Ye</au><au>Zhou, Houguang</au><au>Wu, Guofeng</au><au>Tang, Zhouping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preclinical Studies of Stem Cell Transplantation in Intracerebral Hemorrhage: a Systemic Review and Meta-Analysis</atitle><jtitle>Molecular neurobiology</jtitle><stitle>Mol Neurobiol</stitle><addtitle>Mol Neurobiol</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>53</volume><issue>8</issue><spage>5269</spage><epage>5277</epage><pages>5269-5277</pages><issn>0893-7648</issn><eissn>1559-1182</eissn><abstract>To comprehensively evaluate the therapeutic effects on both functional and structural outcomes, we performed a meta-analysis of preclinical data on stem cell therapy in intracranial hemorrhage, thus providing optimal evidence and instruction for clinical translation. We searched online databases to identify eligible studies based on unmodified stem cell transplantation in intracranial hemorrhage (ICH). From each study, we extracted data regarding neurobehavioral and histological outcomes in order to analyze the comprehensive effective sizes according to the most important clinical parameters (seven indices) and to explore any potential correlation through meta-regression. We analyzed 40 eligible studies including 1021 animals and found a significant improvement in both behavioral and structural outcomes with the median effect size of 1.77 for modified Neurological Severity Score, 1.16 for the modified placement test, 1.82 for the rotarod test, and 1.24 for tissue loss reduction. The meta-regression results revealed that intracerebral administration was the most effective for behavioral and structural recovery post-ICH; mesenchymal stem cells shared comparable therapeutic effects with neural stem cells. Delayed therapy, applied more than 1 week after ICH, showed the greatest improvement of structural outcomes. Stem cell therapy showed significant improvement on behavioral and structural outcomes of ICH animals with relatively large effect sizes. However, the practical efficacy of the therapy is likely to be lower considering poor study quality and non-negligible publication bias. Further, future research should interpret animal results cautiously considering the limited internal and external validity when referring to the design of both animal studies and clinical trials.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>26409481</pmid><doi>10.1007/s12035-015-9441-6</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biomedical and Life Sciences Biomedicine Cell Biology Cerebral Hemorrhage - therapy Hemorrhage Meta-analysis Neurobiology Neurology Neurosciences Publication Bias Regression Analysis Stem Cell Transplantation Stem cells Systematic review |
| title | Preclinical Studies of Stem Cell Transplantation in Intracerebral Hemorrhage: a Systemic Review and Meta-Analysis |
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