Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models

Gaucher disease is caused by inherited deficiency of lysosomal glucocerebrosidase. Proteome analysis of laser‐dissected splenic Gaucher cells revealed increased amounts of glycoprotein nonmetastatic melanoma protein B (gpNMB). Plasma gpNMB was also elevated, correlating with chitotriosidase and CCL1...

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Veröffentlicht in:	FEBS open bio 2016-09, Vol.6 (9), p.902-913
Hauptverfasser:	Kramer, Gertjan, Wegdam, Wouter, Donker‐Koopman, Wilma, Ottenhoff, Roelof, Gaspar, Paulo, Verhoek, Marri, Nelson, Jessica, Gabriel, Tanit, Kallemeijn, Wouter, Boot, Rolf G., Laman, Jon D., Vissers, Johannes P.C., Cox, Timothy, Pavlova, Elena, Moran, Mary Teresa, Aerts, Johannes M., Eijk, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Biomarkers Blood Bone marrow CCL18 protein Chemokines chitotriosidase DC‐HIL Enzymes Gaucher's disease Gene transfer Glucosylceramidase glucosylceramide Glycoproteins Heparan sulfate Lipids lysosome Macrophages Melanoma Mutation osteoactivin Patients Protein B Proteomes R&D Research & development Spleen storage disease
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