Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden

Treatment with celecoxib, a selective COX-2 inhibitor, reduces formation of premalignant adenomatous polyps in the gastrointestinal tracts of humans and mice. In addition to its chemopreventive activity, celecoxib can exhibit antimicrobial activity. Differing bacterial profiles have been found in fe...

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Veröffentlicht in:	Cancer prevention research (Philadelphia, Pa.) Pa.), 2016-09, Vol.9 (9), p.721-731
Hauptverfasser:	Montrose, David C, Zhou, Xi Kathy, McNally, Erin M, Sue, Erika, Yantiss, Rhonda K, Gross, Steven S, Leve, Nitai D, Karoly, Edward D, Suen, Chen S, Ling, Lilan, Benezra, Robert, Pamer, Eric G, Dannenberg, Andrew J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Celecoxib - pharmacology Cell Proliferation - drug effects Cyclooxygenase 2 Inhibitors - pharmacology Feces - chemistry Feces - microbiology Gastrointestinal Microbiome - drug effects Intestinal Polyps - pathology Male Metabolome - drug effects Mice
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