Long-Term Air Pollution and Traffic Noise Exposures and Mild Cognitive Impairment in Older Adults: A Cross-Sectional Analysis of the Heinz Nixdorf Recall Study
Mild cognitive impairment (MCI) describes the intermediate state between normal cognitive aging and dementia. Adverse effects of air pollution (AP) on cognitive functions have been proposed, but investigations of simultaneous exposure to noise are scarce. We analyzed the cross-sectional associations...
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| creator | Tzivian, Lilian Dlugaj, Martha Winkler, Angela Weinmayr, Gudrun Hennig, Frauke Fuks, Kateryna B Vossoughi, Mohammad Schikowski, Tamara Weimar, Christian Erbel, Raimund Jöckel, Karl-Heinz Moebus, Susanne Hoffmann, Barbara |
| description | Mild cognitive impairment (MCI) describes the intermediate state between normal cognitive aging and dementia. Adverse effects of air pollution (AP) on cognitive functions have been proposed, but investigations of simultaneous exposure to noise are scarce.
We analyzed the cross-sectional associations of long-term exposure to AP and traffic noise with overall MCI and amnestic (aMCI) and nonamnestic (naMCI) MCI.
At the second examination of the population-based Heinz Nixdorf Recall study, cognitive assessment was completed in 4,086 participants who were 50-80 years old. Of these, 592 participants were diagnosed as having MCI (aMCI, n = 309; naMCI, n = 283) according to previously published criteria using five neuropsychological subtests. We assessed long-term residential concentrations for size-fractioned particulate matter (PM) and nitrogen oxides with land use regression, and for traffic noise [weighted 24-hr (LDEN) and night-time (LNIGHT) means]. Logistic regression models adjusted for individual risk factors were calculated to estimate the association of environmental exposures with MCI in single- and two-exposure models.
Most air pollutants and traffic noise were associated with overall MCI and aMCI. For example, an interquartile range increase in PM2.5 and a 10 A-weighted decibel [dB(A)] increase in LDEN were associated with overall MCI as follows [odds ratio (95% confidence interval)]: 1.16 (1.05, 1.27) and 1.40 (1.03, 1.91), respectively, and with aMCI as follows: 1.22 (1.08, 1.38) and 1.53 (1.05, 2.24), respectively. In two-exposure models, AP and noise associations were attenuated [e.g., for aMCI, PM2.5 1.13 (0.98, 1.30) and LDEN 1.46 (1.11, 1.92)].
Long-term exposures to air pollution and traffic noise were positively associated with MCI, mainly with the amnestic subtype.
Tzivian L, Dlugaj M, Winkler A, Weinmayr G, Hennig F, Fuks KB, Vossoughi M, Schikowski T, Weimar C, Erbel R, Jöckel KH, Moebus S, Hoffmann B, on behalf of the Heinz Nixdorf Recall study Investigative Group. 2016. Long-term air pollution and traffic noise exposures and mild cognitive impairment in older adults: a cross-sectional analysis of the Heinz Nixdorf Recall Study. Environ Health Perspect 124:1361-1368; http://dx.doi.org/10.1289/ehp.1509824. |
| doi_str_mv | 10.1289/ehp.1509824 |
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We analyzed the cross-sectional associations of long-term exposure to AP and traffic noise with overall MCI and amnestic (aMCI) and nonamnestic (naMCI) MCI.
At the second examination of the population-based Heinz Nixdorf Recall study, cognitive assessment was completed in 4,086 participants who were 50-80 years old. Of these, 592 participants were diagnosed as having MCI (aMCI, n = 309; naMCI, n = 283) according to previously published criteria using five neuropsychological subtests. We assessed long-term residential concentrations for size-fractioned particulate matter (PM) and nitrogen oxides with land use regression, and for traffic noise [weighted 24-hr (LDEN) and night-time (LNIGHT) means]. Logistic regression models adjusted for individual risk factors were calculated to estimate the association of environmental exposures with MCI in single- and two-exposure models.
Most air pollutants and traffic noise were associated with overall MCI and aMCI. For example, an interquartile range increase in PM2.5 and a 10 A-weighted decibel [dB(A)] increase in LDEN were associated with overall MCI as follows [odds ratio (95% confidence interval)]: 1.16 (1.05, 1.27) and 1.40 (1.03, 1.91), respectively, and with aMCI as follows: 1.22 (1.08, 1.38) and 1.53 (1.05, 2.24), respectively. In two-exposure models, AP and noise associations were attenuated [e.g., for aMCI, PM2.5 1.13 (0.98, 1.30) and LDEN 1.46 (1.11, 1.92)].
Long-term exposures to air pollution and traffic noise were positively associated with MCI, mainly with the amnestic subtype.
Tzivian L, Dlugaj M, Winkler A, Weinmayr G, Hennig F, Fuks KB, Vossoughi M, Schikowski T, Weimar C, Erbel R, Jöckel KH, Moebus S, Hoffmann B, on behalf of the Heinz Nixdorf Recall study Investigative Group. 2016. Long-term air pollution and traffic noise exposures and mild cognitive impairment in older adults: a cross-sectional analysis of the Heinz Nixdorf Recall Study. Environ Health Perspect 124:1361-1368; http://dx.doi.org/10.1289/ehp.1509824.</description><identifier>ISSN: 0091-6765</identifier><identifier>ISSN: 1552-9924</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.1509824</identifier><identifier>PMID: 26863687</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Aged ; Aged, 80 and over ; Air Pollutants - adverse effects ; Air pollution ; Air Pollution - adverse effects ; Cognition disorders ; Cognitive Dysfunction - chemically induced ; Cognitive Dysfunction - epidemiology ; Cohort Studies ; Cross-Sectional Studies ; Environmental aspects ; Environmental Exposure ; Female ; Germany - epidemiology ; Health aspects ; Humans ; Male ; Middle Aged ; Nitrogen Oxides - adverse effects ; Noise, Transportation - adverse effects ; Particulate Matter - adverse effects ; Risk Factors ; Time Factors ; Traffic noise</subject><ispartof>Environmental health perspectives, 2016-09, Vol.124 (9), p.1361-1368</ispartof><rights>COPYRIGHT 2016 National Institute of Environmental Health Sciences</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c613t-35b43bdec2982199be4b788c6f05744b0641b18cb35184e994f96e898900f7013</citedby><cites>FETCH-LOGICAL-c613t-35b43bdec2982199be4b788c6f05744b0641b18cb35184e994f96e898900f7013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010410/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010410/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26863687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tzivian, Lilian</creatorcontrib><creatorcontrib>Dlugaj, Martha</creatorcontrib><creatorcontrib>Winkler, Angela</creatorcontrib><creatorcontrib>Weinmayr, Gudrun</creatorcontrib><creatorcontrib>Hennig, Frauke</creatorcontrib><creatorcontrib>Fuks, Kateryna B</creatorcontrib><creatorcontrib>Vossoughi, Mohammad</creatorcontrib><creatorcontrib>Schikowski, Tamara</creatorcontrib><creatorcontrib>Weimar, Christian</creatorcontrib><creatorcontrib>Erbel, Raimund</creatorcontrib><creatorcontrib>Jöckel, Karl-Heinz</creatorcontrib><creatorcontrib>Moebus, Susanne</creatorcontrib><creatorcontrib>Hoffmann, Barbara</creatorcontrib><creatorcontrib>Heinz Nixdorf Recall study Investigative Group</creatorcontrib><creatorcontrib>on behalf of the Heinz Nixdorf Recall study Investigative Group</creatorcontrib><title>Long-Term Air Pollution and Traffic Noise Exposures and Mild Cognitive Impairment in Older Adults: A Cross-Sectional Analysis of the Heinz Nixdorf Recall Study</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Mild cognitive impairment (MCI) describes the intermediate state between normal cognitive aging and dementia. Adverse effects of air pollution (AP) on cognitive functions have been proposed, but investigations of simultaneous exposure to noise are scarce.
We analyzed the cross-sectional associations of long-term exposure to AP and traffic noise with overall MCI and amnestic (aMCI) and nonamnestic (naMCI) MCI.
At the second examination of the population-based Heinz Nixdorf Recall study, cognitive assessment was completed in 4,086 participants who were 50-80 years old. Of these, 592 participants were diagnosed as having MCI (aMCI, n = 309; naMCI, n = 283) according to previously published criteria using five neuropsychological subtests. We assessed long-term residential concentrations for size-fractioned particulate matter (PM) and nitrogen oxides with land use regression, and for traffic noise [weighted 24-hr (LDEN) and night-time (LNIGHT) means]. Logistic regression models adjusted for individual risk factors were calculated to estimate the association of environmental exposures with MCI in single- and two-exposure models.
Most air pollutants and traffic noise were associated with overall MCI and aMCI. For example, an interquartile range increase in PM2.5 and a 10 A-weighted decibel [dB(A)] increase in LDEN were associated with overall MCI as follows [odds ratio (95% confidence interval)]: 1.16 (1.05, 1.27) and 1.40 (1.03, 1.91), respectively, and with aMCI as follows: 1.22 (1.08, 1.38) and 1.53 (1.05, 2.24), respectively. In two-exposure models, AP and noise associations were attenuated [e.g., for aMCI, PM2.5 1.13 (0.98, 1.30) and LDEN 1.46 (1.11, 1.92)].
Long-term exposures to air pollution and traffic noise were positively associated with MCI, mainly with the amnestic subtype.
Tzivian L, Dlugaj M, Winkler A, Weinmayr G, Hennig F, Fuks KB, Vossoughi M, Schikowski T, Weimar C, Erbel R, Jöckel KH, Moebus S, Hoffmann B, on behalf of the Heinz Nixdorf Recall study Investigative Group. 2016. Long-term air pollution and traffic noise exposures and mild cognitive impairment in older adults: a cross-sectional analysis of the Heinz Nixdorf Recall Study. Environ Health Perspect 124:1361-1368; http://dx.doi.org/10.1289/ehp.1509824.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Air Pollutants - adverse effects</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Cognition disorders</subject><subject>Cognitive Dysfunction - chemically induced</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Environmental aspects</subject><subject>Environmental Exposure</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nitrogen Oxides - adverse effects</subject><subject>Noise, Transportation - adverse effects</subject><subject>Particulate Matter - adverse effects</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Traffic noise</subject><issn>0091-6765</issn><issn>1552-9924</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0m-L0zAcB_AiineePvK5BARRpDPpnyy5B0IZpzeYN7lNn4Y0_bWLpM1M2mPzzfhWzdw8brAHUkih-eQbmnyj6CXBI5Iw_gFW6xHJMWdJ9ig6J3mexJwn2ePoHGNOYjqm-Vn0zPsfGGPCKH0anSWU0ZSy8Xn0e2a7Jl6Ca1GhHfpqjRl6bTskuwotnaxrrdCN1R7Q1WZt_eDA_537ok2FJrbpdK_vAE3btdSuha5HukNzU4FDRTWY3l-iAk2c9T5egNpFS4OKMGy99sjWqF8Bugbd_UI3elNZV6NbUNIYtOiHavs8elJL4-HF4X0Rfft0tZxcx7P55-mkmMWKkrSP07zM0rIClYRjIJyXkJVjxhStcT7OshLTjJSEqTLNCcuA86zmFBhnHON6jEl6EX3c566HsoVKhR9x0oi10610W2GlFscznV6Jxt6JHBOcERwC3h4CnP05gO9Fq70CY2QHdvCCMEJpmoyTPNDXe9pIA0J3tQ2JasdFkQXDE5wlQcUnVAMdhO1tB7UOn4_86IQPTwWtVicXvDtaEEwPm76Rg_diurj9fzv_fmzfPLArkKZfebuvlT-G7_dQ7erhoL4_boLFrtoiVFscqh30q4c3dG__dTn9A-1d8T4</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Tzivian, Lilian</creator><creator>Dlugaj, Martha</creator><creator>Winkler, Angela</creator><creator>Weinmayr, Gudrun</creator><creator>Hennig, Frauke</creator><creator>Fuks, Kateryna B</creator><creator>Vossoughi, Mohammad</creator><creator>Schikowski, Tamara</creator><creator>Weimar, Christian</creator><creator>Erbel, Raimund</creator><creator>Jöckel, Karl-Heinz</creator><creator>Moebus, Susanne</creator><creator>Hoffmann, Barbara</creator><general>National Institute of Environmental Health Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160901</creationdate><title>Long-Term Air Pollution and Traffic Noise Exposures and Mild Cognitive Impairment in Older Adults: A Cross-Sectional Analysis of the Heinz Nixdorf Recall Study</title><author>Tzivian, Lilian ; Dlugaj, Martha ; Winkler, Angela ; Weinmayr, Gudrun ; Hennig, Frauke ; Fuks, Kateryna B ; Vossoughi, Mohammad ; Schikowski, Tamara ; Weimar, Christian ; Erbel, Raimund ; Jöckel, Karl-Heinz ; Moebus, Susanne ; Hoffmann, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c613t-35b43bdec2982199be4b788c6f05744b0641b18cb35184e994f96e898900f7013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Air Pollutants - adverse effects</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Cognition disorders</topic><topic>Cognitive Dysfunction - chemically induced</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Environmental aspects</topic><topic>Environmental Exposure</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nitrogen Oxides - adverse effects</topic><topic>Noise, Transportation - adverse effects</topic><topic>Particulate Matter - adverse effects</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Traffic noise</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tzivian, Lilian</creatorcontrib><creatorcontrib>Dlugaj, Martha</creatorcontrib><creatorcontrib>Winkler, Angela</creatorcontrib><creatorcontrib>Weinmayr, Gudrun</creatorcontrib><creatorcontrib>Hennig, Frauke</creatorcontrib><creatorcontrib>Fuks, Kateryna B</creatorcontrib><creatorcontrib>Vossoughi, Mohammad</creatorcontrib><creatorcontrib>Schikowski, Tamara</creatorcontrib><creatorcontrib>Weimar, Christian</creatorcontrib><creatorcontrib>Erbel, Raimund</creatorcontrib><creatorcontrib>Jöckel, Karl-Heinz</creatorcontrib><creatorcontrib>Moebus, Susanne</creatorcontrib><creatorcontrib>Hoffmann, Barbara</creatorcontrib><creatorcontrib>Heinz Nixdorf Recall study Investigative Group</creatorcontrib><creatorcontrib>on behalf of the Heinz Nixdorf Recall study Investigative Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tzivian, Lilian</au><au>Dlugaj, Martha</au><au>Winkler, Angela</au><au>Weinmayr, Gudrun</au><au>Hennig, Frauke</au><au>Fuks, Kateryna B</au><au>Vossoughi, Mohammad</au><au>Schikowski, Tamara</au><au>Weimar, Christian</au><au>Erbel, Raimund</au><au>Jöckel, Karl-Heinz</au><au>Moebus, Susanne</au><au>Hoffmann, Barbara</au><aucorp>Heinz Nixdorf Recall study Investigative Group</aucorp><aucorp>on behalf of the Heinz Nixdorf Recall study Investigative Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Air Pollution and Traffic Noise Exposures and Mild Cognitive Impairment in Older Adults: A Cross-Sectional Analysis of the Heinz Nixdorf Recall Study</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>124</volume><issue>9</issue><spage>1361</spage><epage>1368</epage><pages>1361-1368</pages><issn>0091-6765</issn><issn>1552-9924</issn><eissn>1552-9924</eissn><abstract>Mild cognitive impairment (MCI) describes the intermediate state between normal cognitive aging and dementia. Adverse effects of air pollution (AP) on cognitive functions have been proposed, but investigations of simultaneous exposure to noise are scarce.
We analyzed the cross-sectional associations of long-term exposure to AP and traffic noise with overall MCI and amnestic (aMCI) and nonamnestic (naMCI) MCI.
At the second examination of the population-based Heinz Nixdorf Recall study, cognitive assessment was completed in 4,086 participants who were 50-80 years old. Of these, 592 participants were diagnosed as having MCI (aMCI, n = 309; naMCI, n = 283) according to previously published criteria using five neuropsychological subtests. We assessed long-term residential concentrations for size-fractioned particulate matter (PM) and nitrogen oxides with land use regression, and for traffic noise [weighted 24-hr (LDEN) and night-time (LNIGHT) means]. Logistic regression models adjusted for individual risk factors were calculated to estimate the association of environmental exposures with MCI in single- and two-exposure models.
Most air pollutants and traffic noise were associated with overall MCI and aMCI. For example, an interquartile range increase in PM2.5 and a 10 A-weighted decibel [dB(A)] increase in LDEN were associated with overall MCI as follows [odds ratio (95% confidence interval)]: 1.16 (1.05, 1.27) and 1.40 (1.03, 1.91), respectively, and with aMCI as follows: 1.22 (1.08, 1.38) and 1.53 (1.05, 2.24), respectively. In two-exposure models, AP and noise associations were attenuated [e.g., for aMCI, PM2.5 1.13 (0.98, 1.30) and LDEN 1.46 (1.11, 1.92)].
Long-term exposures to air pollution and traffic noise were positively associated with MCI, mainly with the amnestic subtype.
Tzivian L, Dlugaj M, Winkler A, Weinmayr G, Hennig F, Fuks KB, Vossoughi M, Schikowski T, Weimar C, Erbel R, Jöckel KH, Moebus S, Hoffmann B, on behalf of the Heinz Nixdorf Recall study Investigative Group. 2016. Long-term air pollution and traffic noise exposures and mild cognitive impairment in older adults: a cross-sectional analysis of the Heinz Nixdorf Recall Study. Environ Health Perspect 124:1361-1368; http://dx.doi.org/10.1289/ehp.1509824.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>26863687</pmid><doi>10.1289/ehp.1509824</doi><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Aged Aged, 80 and over Air Pollutants - adverse effects Air pollution Air Pollution - adverse effects Cognition disorders Cognitive Dysfunction - chemically induced Cognitive Dysfunction - epidemiology Cohort Studies Cross-Sectional Studies Environmental aspects Environmental Exposure Female Germany - epidemiology Health aspects Humans Male Middle Aged Nitrogen Oxides - adverse effects Noise, Transportation - adverse effects Particulate Matter - adverse effects Risk Factors Time Factors Traffic noise |
| title | Long-Term Air Pollution and Traffic Noise Exposures and Mild Cognitive Impairment in Older Adults: A Cross-Sectional Analysis of the Heinz Nixdorf Recall Study |
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