Structural Determinants of Sleeping Beauty Transposase Activity

Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work suggests that protein coevolutionary information can be...

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Veröffentlicht in:	Molecular therapy 2016-08, Vol.24 (8), p.1369-1377
Hauptverfasser:	Abrusán, György, Yant, Stephen R, Szilágyi, András, Marsh, Joseph A, Mátés, Lajos, Izsvák, Zsuzsanna, Barabás, Orsolya, Ivics, Zoltán
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological research Carrier Proteins - metabolism Conserved Sequence DNA Transposable Elements Engineering Evolution Gene therapy Genetic Vectors - genetics Genomes Homologous Recombination Hyperactivity Medicine Models, Molecular Mutagenesis Mutation Original Protein Binding Protein Conformation Protein Interaction Domains and Motifs Protein Multimerization Protein Stability Proteins Structure-Activity Relationship Transposases - chemistry Transposases - genetics Transposases - metabolism Vectors (Biology)
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