SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule

Key points STE20 (Sterile 20)/SPS‐1 related proline/alanine‐rich kinase (SPAK) and oxidative stress‐response kinase‐1 (OSR1) phosphorylate and activate the renal Na+–K+–2Cl− cotransporter 2 (NKCC2) and Na+Cl− cotransporter (NCC). Mouse models suggest that OSR1 mainly activates NKCC2‐mediated sodium...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of physiology 2016-09, Vol.594 (17), p.4945-4966
Hauptverfasser:	Ferdaus, Mohammed Z., Barber, Karl W., López‐Cayuqueo, Karen I., Terker, Andrew S., Argaiz, Eduardo R., Gassaway, Brandon M., Chambrey, Régine, Gamba, Gerardo, Rinehart, Jesse, McCormick, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure Homeostasis Kidney Tubules, Distal - metabolism Kidney Tubules, Distal - physiology Kinases Male Mice Mice, Knockout Oxidative stress Phosphorylation Potassium - metabolism Potassium - physiology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Renal and endocrine Renal Filtration Renal Physiology Research Paper Rodents Sodium Solute Carrier Family 12, Member 1 - metabolism Solute Carrier Family 12, Member 3 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!