Deletion of interleukin-6 in monocytes/macrophages suppresses the initiation of hepatocellular carcinoma in mice

Hepatocellular carcinoma (HCC) is associated with inflammation, and roughly 30 % of the global population shows serological evidence of current or past infection with hepatitis B or hepatitis C virus. Resident hepatic macrophages, known as Kupffer cells (KCs), are considered as the specific tumor-as...

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Veröffentlicht in:	Journal of experimental & clinical cancer research 2016-09, Vol.35 (1), p.131, Article 131
Hauptverfasser:	Kong, Lingxiang, Zhou, Yongjie, Bu, Hong, Lv, Tao, Shi, Yujun, Yang, Jiayin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals ATP Binding Cassette Transporter, Subfamily B - deficiency ATP-Binding Cassette Sub-Family B Member 4 Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - immunology Care and treatment Diagnosis Dosage and administration Female Gene Deletion Gene mutations Hepatoma Humans Inflammation Interleukin-6 Interleukin-6 - blood Interleukin-6 - genetics Kupffer Cells - immunology Leukocyte Count Liver Neoplasms - blood Liver Neoplasms - genetics Liver Neoplasms - immunology Macrophages Male Mice Middle Aged Neoplasms, Experimental Risk factors
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