The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding

Chemical exposure of cells may damage biomolecules, cellular structures, and organelles thereby jeopardizing cellular homeostasis. A multitude of defense mechanisms have evolved that can recognize specific types of damaged molecules and will initiate distinct cellular programs aiming to remove the d...

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Veröffentlicht in:	Toxicological sciences 2016-03, Vol.150 (1), p.190-203
Hauptverfasser:	Hendriks, Giel, Derr, Remco S, Misovic, Branislav, Morolli, Bruno, Calléja, Fabienne M G R, Vrieling, Harry
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Cell Line Cell Survival - drug effects DNA Damage Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Embryonic Stem Cells - pathology Expanded ToxTracker Assay for Genotoxicity Genes, Reporter Green Fluorescent Proteins - genetics High-Throughput Screening Assays Mice Mutagenicity Tests - methods Oxidative Stress - drug effects Oxidative Stress - genetics Protein Folding - drug effects Reproducibility of Results
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