Mitochondrial Metabolism in Aging Heart

Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased capacity to oxidize fatty acids and enhanced dependence on glucose metabolism. Aging impairs mitochondrial oxid...

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Veröffentlicht in:	Circulation research 2016-05, Vol.118 (10), p.1593-1611
Hauptverfasser:	Lesnefsky, Edward J, Chen, Qun, Hoppel, Charles L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aging - pathology Animals Electron Transport Chain Complex Proteins - genetics Electron Transport Chain Complex Proteins - metabolism Heart - growth & development Heart - physiopathology Humans Mitochondria, Heart - metabolism Organelle Biogenesis Oxidative Stress
Online-Zugang:	Volltext
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