Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer

The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments. This type of migration has been shown to require the expression of the hypoxia-inducible factor 1 alpha (HIF-1α). In this report we...

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Veröffentlicht in:	Oncotarget 2016-04, Vol.7 (16), p.22650-22664
Hauptverfasser:	Gomez-Roman, Natividad, Sahasrabudhe, Neha Mohan, McGregor, Fiona, Chalmers, Anthony J, Cassidy, Jim, Plumb, Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Ovarian Epithelial Cell Line, Tumor Female Gene Expression Regulation, Neoplastic - physiology Heterografts Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Mice, Nude Neoplasm Invasiveness - pathology Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phenotype rab GTP-Binding Proteins - metabolism Research Paper
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