Extended followup of a cohort of chromium production workers
Background The current study evaluates the mortality of 2,354 workers first employed at a Baltimore chromate production plant between 1950 and 1974. Methods The National Death Index (NDI Plus) was used to determine vital status and cause of death. Cumulative chromium (VI) exposure and nasal and skin...
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| Veröffentlicht in: | American journal of industrial medicine 2015-08, Vol.58 (8), p.905-913 |
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| container_title | American journal of industrial medicine |
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| creator | Gibb, Herman Jones Lees, Peter St. John Wang, Jing Grace O'Leary, Keri |
| description | Background
The current study evaluates the mortality of 2,354 workers first employed at a Baltimore chromate production plant between 1950 and 1974.
Methods
The National Death Index (NDI Plus) was used to determine vital status and cause of death. Cumulative chromium (VI) exposure and nasal and skin irritation were evaluated as risk factors for lung cancer mortality.
Results
There are 91,186 person‐years of observation and 217 lung cancer deaths. Cumulative chromium (VI) exposure, nasal irritation, nasal perforation, nasal ulceration, and other forms of irritation (e.g., skin irritation) were associated with lung cancer mortality.
Conclusion
Cumulative chromium (VI) exposure was a risk factor for lung cancer death. Cancer deaths, other than lung cancer, were not significantly elevated. Irritation may be a possible mechanism for chromium (VI)‐induced lung cancer. Am. J. Ind. Med. 58:905–913, 2015. © 2015 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/ajim.22479 |
| format | Article |
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The current study evaluates the mortality of 2,354 workers first employed at a Baltimore chromate production plant between 1950 and 1974.
Methods
The National Death Index (NDI Plus) was used to determine vital status and cause of death. Cumulative chromium (VI) exposure and nasal and skin irritation were evaluated as risk factors for lung cancer mortality.
Results
There are 91,186 person‐years of observation and 217 lung cancer deaths. Cumulative chromium (VI) exposure, nasal irritation, nasal perforation, nasal ulceration, and other forms of irritation (e.g., skin irritation) were associated with lung cancer mortality.
Conclusion
Cumulative chromium (VI) exposure was a risk factor for lung cancer death. Cancer deaths, other than lung cancer, were not significantly elevated. Irritation may be a possible mechanism for chromium (VI)‐induced lung cancer. Am. J. Ind. Med. 58:905–913, 2015. © 2015 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc.</description><identifier>ISSN: 0271-3586</identifier><identifier>EISSN: 1097-0274</identifier><identifier>DOI: 10.1002/ajim.22479</identifier><identifier>PMID: 26041683</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Baltimore - epidemiology ; chromium (III) ; chromium (VI) ; Chromium - toxicity ; Follow-Up Studies ; Humans ; irritation ; lung cancer ; Lung Neoplasms - chemically induced ; Lung Neoplasms - mortality ; Male ; Metallurgy - statistics & numerical data ; Middle Aged ; Nose Diseases - chemically induced ; Nose Diseases - complications ; Occupational Diseases - chemically induced ; Occupational Diseases - mortality ; Occupational Exposure - adverse effects ; Risk Factors ; Skin Diseases - chemically induced ; Skin Diseases - complications ; smoking ; Time Factors</subject><ispartof>American journal of industrial medicine, 2015-08, Vol.58 (8), p.905-913</ispartof><rights>2015 The Authors. Published by Wiley Periodicals, Inc.</rights><rights>2015 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc.</rights><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6559-ca9f423f557b6126b0c722d713030b5bd9c9f5f59a1a6d27fa8dd1603293cd733</citedby><cites>FETCH-LOGICAL-c6559-ca9f423f557b6126b0c722d713030b5bd9c9f5f59a1a6d27fa8dd1603293cd733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajim.22479$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajim.22479$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26041683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gibb, Herman Jones</creatorcontrib><creatorcontrib>Lees, Peter St. John</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Grace O'Leary, Keri</creatorcontrib><title>Extended followup of a cohort of chromium production workers</title><title>American journal of industrial medicine</title><addtitle>Am. J. Ind. Med</addtitle><description>Background
The current study evaluates the mortality of 2,354 workers first employed at a Baltimore chromate production plant between 1950 and 1974.
Methods
The National Death Index (NDI Plus) was used to determine vital status and cause of death. Cumulative chromium (VI) exposure and nasal and skin irritation were evaluated as risk factors for lung cancer mortality.
Results
There are 91,186 person‐years of observation and 217 lung cancer deaths. Cumulative chromium (VI) exposure, nasal irritation, nasal perforation, nasal ulceration, and other forms of irritation (e.g., skin irritation) were associated with lung cancer mortality.
Conclusion
Cumulative chromium (VI) exposure was a risk factor for lung cancer death. Cancer deaths, other than lung cancer, were not significantly elevated. Irritation may be a possible mechanism for chromium (VI)‐induced lung cancer. Am. J. Ind. Med. 58:905–913, 2015. © 2015 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Baltimore - epidemiology</subject><subject>chromium (III)</subject><subject>chromium (VI)</subject><subject>Chromium - toxicity</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>irritation</subject><subject>lung cancer</subject><subject>Lung Neoplasms - chemically induced</subject><subject>Lung Neoplasms - mortality</subject><subject>Male</subject><subject>Metallurgy - statistics & numerical data</subject><subject>Middle Aged</subject><subject>Nose Diseases - chemically induced</subject><subject>Nose Diseases - complications</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational Diseases - mortality</subject><subject>Occupational Exposure - adverse effects</subject><subject>Risk Factors</subject><subject>Skin Diseases - chemically induced</subject><subject>Skin Diseases - complications</subject><subject>smoking</subject><subject>Time Factors</subject><issn>0271-3586</issn><issn>1097-0274</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0Eokvhwg9AkbhUSCljO7ZjCSFVVdkWdemlqEfL8QfrbRIvdtJt_z1Ztl0BB04z0jzzaOwXobcYjjEA-ahXoTsmpBLyGZphkKIEIqrnaDYVXFJW8wP0KucVAMYVr16iA8KhwrymM_Tp7H5wvXW28LFt42ZcF9EXujBxGdOw7c0yxS6MXbFO0Y5mCLEvNjHdupRfoxdet9m9eayH6PuXs-vT8_Lyan5xenJZGs6YLI2WviLUMyYajglvwAhCrMAUKDSssdJIzzyTGmtuifC6thZzoERSYwWlh-jzzrsem85Z4_oh6VatU-h0elBRB_X3pA9L9SPeKQZQE6gnwdGjIMWfo8uD6kI2rm117-KYFRaAq5rXWEzo-3_QVRxTPz1PYS45wPSDeKI-7CiTYs7J-f0xGNQ2FLUNRf0OZYLf_Xn-Hn1KYQLwDtiE1j38R6VOvl4snqTlbifkwd3vd3S6VVxQwdTNt7maV2RxfgMLtaC_AMZJpgg</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Gibb, Herman Jones</creator><creator>Lees, Peter St. John</creator><creator>Wang, Jing</creator><creator>Grace O'Leary, Keri</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>BSCLL</scope><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U7</scope><scope>C1K</scope><scope>7U1</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>201508</creationdate><title>Extended followup of a cohort of chromium production workers</title><author>Gibb, Herman Jones ; Lees, Peter St. John ; Wang, Jing ; Grace O'Leary, Keri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6559-ca9f423f557b6126b0c722d713030b5bd9c9f5f59a1a6d27fa8dd1603293cd733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Baltimore - epidemiology</topic><topic>chromium (III)</topic><topic>chromium (VI)</topic><topic>Chromium - toxicity</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>irritation</topic><topic>lung cancer</topic><topic>Lung Neoplasms - chemically induced</topic><topic>Lung Neoplasms - mortality</topic><topic>Male</topic><topic>Metallurgy - statistics & numerical data</topic><topic>Middle Aged</topic><topic>Nose Diseases - chemically induced</topic><topic>Nose Diseases - complications</topic><topic>Occupational Diseases - chemically induced</topic><topic>Occupational Diseases - mortality</topic><topic>Occupational Exposure - adverse effects</topic><topic>Risk Factors</topic><topic>Skin Diseases - chemically induced</topic><topic>Skin Diseases - complications</topic><topic>smoking</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gibb, Herman Jones</creatorcontrib><creatorcontrib>Lees, Peter St. John</creatorcontrib><creatorcontrib>Wang, Jing</creatorcontrib><creatorcontrib>Grace O'Leary, Keri</creatorcontrib><collection>Istex</collection><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of industrial medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibb, Herman Jones</au><au>Lees, Peter St. John</au><au>Wang, Jing</au><au>Grace O'Leary, Keri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extended followup of a cohort of chromium production workers</atitle><jtitle>American journal of industrial medicine</jtitle><addtitle>Am. J. Ind. Med</addtitle><date>2015-08</date><risdate>2015</risdate><volume>58</volume><issue>8</issue><spage>905</spage><epage>913</epage><pages>905-913</pages><issn>0271-3586</issn><eissn>1097-0274</eissn><abstract>Background
The current study evaluates the mortality of 2,354 workers first employed at a Baltimore chromate production plant between 1950 and 1974.
Methods
The National Death Index (NDI Plus) was used to determine vital status and cause of death. Cumulative chromium (VI) exposure and nasal and skin irritation were evaluated as risk factors for lung cancer mortality.
Results
There are 91,186 person‐years of observation and 217 lung cancer deaths. Cumulative chromium (VI) exposure, nasal irritation, nasal perforation, nasal ulceration, and other forms of irritation (e.g., skin irritation) were associated with lung cancer mortality.
Conclusion
Cumulative chromium (VI) exposure was a risk factor for lung cancer death. Cancer deaths, other than lung cancer, were not significantly elevated. Irritation may be a possible mechanism for chromium (VI)‐induced lung cancer. Am. J. Ind. Med. 58:905–913, 2015. © 2015 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26041683</pmid><doi>10.1002/ajim.22479</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Aged, 80 and over Baltimore - epidemiology chromium (III) chromium (VI) Chromium - toxicity Follow-Up Studies Humans irritation lung cancer Lung Neoplasms - chemically induced Lung Neoplasms - mortality Male Metallurgy - statistics & numerical data Middle Aged Nose Diseases - chemically induced Nose Diseases - complications Occupational Diseases - chemically induced Occupational Diseases - mortality Occupational Exposure - adverse effects Risk Factors Skin Diseases - chemically induced Skin Diseases - complications smoking Time Factors |
| title | Extended followup of a cohort of chromium production workers |
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