Mitosis
SUMMARYAll eukaryotic cells prepare for cell division by forming a "mitotic spindle"-a bipolar machine made from microtubules (MTs) and many associated proteins. This device organizes the already duplicated DNA so one copy of each chromosome attaches to each end of the spindle. Both format...
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| Veröffentlicht in: | Cold Spring Harbor perspectives in biology 2016-09, Vol.8 (9), p.a023218 |
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| creator | McIntosh, J Richard |
| description | SUMMARYAll eukaryotic cells prepare for cell division by forming a "mitotic spindle"-a bipolar machine made from microtubules (MTs) and many associated proteins. This device organizes the already duplicated DNA so one copy of each chromosome attaches to each end of the spindle. Both formation and function of the spindle require controlled MT dynamics, as well as the actions of multiple motor enzymes. Spindle-driven motions separate the duplicated chromosomes into two distinct sets that are then moved toward opposite ends of the cell. The two cells that subsequently form by cytokinesis, therefore, contain all the genes needed to grow and divide again. |
| doi_str_mv | 10.1101/cshperspect.a023218 |
| format | Article |
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This device organizes the already duplicated DNA so one copy of each chromosome attaches to each end of the spindle. Both formation and function of the spindle require controlled MT dynamics, as well as the actions of multiple motor enzymes. Spindle-driven motions separate the duplicated chromosomes into two distinct sets that are then moved toward opposite ends of the cell. The two cells that subsequently form by cytokinesis, therefore, contain all the genes needed to grow and divide again.</description><identifier>ISSN: 1943-0264</identifier><identifier>EISSN: 1943-0264</identifier><identifier>DOI: 10.1101/cshperspect.a023218</identifier><identifier>PMID: 27587616</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Animals ; Chromosomes, Human ; CONCEPTS ; Humans ; Mitosis ; Spindle Apparatus</subject><ispartof>Cold Spring Harbor perspectives in biology, 2016-09, Vol.8 (9), p.a023218</ispartof><rights>Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved.</rights><rights>Copyright © 2016 Cold Spring Harbor Laboratory Press; all rights reserved 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-3bd38b32f8016ff523bf811240a8a3f154a70c1b4bffe418a31c6808d7a59e8c3</citedby><cites>FETCH-LOGICAL-c405t-3bd38b32f8016ff523bf811240a8a3f154a70c1b4bffe418a31c6808d7a59e8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008068/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008068/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27587616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McIntosh, J Richard</creatorcontrib><title>Mitosis</title><title>Cold Spring Harbor perspectives in biology</title><addtitle>Cold Spring Harb Perspect Biol</addtitle><description>SUMMARYAll eukaryotic cells prepare for cell division by forming a "mitotic spindle"-a bipolar machine made from microtubules (MTs) and many associated proteins. 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The two cells that subsequently form by cytokinesis, therefore, contain all the genes needed to grow and divide again.</description><subject>Animals</subject><subject>Chromosomes, Human</subject><subject>CONCEPTS</subject><subject>Humans</subject><subject>Mitosis</subject><subject>Spindle Apparatus</subject><issn>1943-0264</issn><issn>1943-0264</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE9PwzAMxSME2sbgEyBx5tJhJ2nqXpDQxD9piAucozRNWFG3lqRF4ttTtDKNky37vWfrx9gFwgIR8NrGdetCbJ3tFga44EhHbIa5FAlwJY8P-ik7jfEDQKmc1IRNeZZSplDN2OS56ppYxTN24k0d3flY5-zt_u51-ZisXh6elrerxEpIu0QUpaBCcE-AyvuUi8ITIpdgyAiPqTQZWCxk4b2TOMzQKgIqM5PmjqyYs5tdbtsXG1dat-2CqXUbqo0J37oxlf6_2VZr_d586RSAQNEQcDUGhOazd7HTmypaV9dm65o-aiRUSiBSPkjFTmpDE2Nwfn8GQf8i1AcI9YhwcF0efrj3_DETP9e5b1w</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>McIntosh, J Richard</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160901</creationdate><title>Mitosis</title><author>McIntosh, J Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-3bd38b32f8016ff523bf811240a8a3f154a70c1b4bffe418a31c6808d7a59e8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Chromosomes, Human</topic><topic>CONCEPTS</topic><topic>Humans</topic><topic>Mitosis</topic><topic>Spindle Apparatus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McIntosh, J Richard</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cold Spring Harbor perspectives in biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McIntosh, J Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitosis</atitle><jtitle>Cold Spring Harbor perspectives in biology</jtitle><addtitle>Cold Spring Harb Perspect Biol</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>8</volume><issue>9</issue><spage>a023218</spage><pages>a023218-</pages><issn>1943-0264</issn><eissn>1943-0264</eissn><abstract>SUMMARYAll eukaryotic cells prepare for cell division by forming a "mitotic spindle"-a bipolar machine made from microtubules (MTs) and many associated proteins. 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| fulltext | fulltext |
| identifier | ISSN: 1943-0264 |
| ispartof | Cold Spring Harbor perspectives in biology, 2016-09, Vol.8 (9), p.a023218 |
| issn | 1943-0264 1943-0264 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Chromosomes, Human CONCEPTS Humans Mitosis Spindle Apparatus |
| title | Mitosis |
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