HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis
Heat-stable antifungal factor (HSAF) belongs to polycyclic tetramate macrolactams (PTMs), which inhibits many fungal pathogens and is effective in inhibiting s ( ). In this study, we found that HSAF induced the apoptosis of s SC5314 through inducing the production of reactive oxygen species (ROS). N...
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| Veröffentlicht in: | RSC advances 2016-01, Vol.6 (37), p.30895-30904 |
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| container_issue | 37 |
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| container_title | RSC advances |
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| creator | Ding, Yanjiao Li, Zhenyu Li, Yaoyao Lu, Chunhua Wang, Haoxin Shen, Yuemao Du, Liangcheng |
| description | Heat-stable antifungal factor (HSAF) belongs to polycyclic tetramate macrolactams (PTMs), which inhibits many fungal pathogens and is effective in inhibiting
s (
). In this study, we found that HSAF induced the apoptosis of
s SC5314 through inducing the production of reactive oxygen species (ROS). Nevertheless, we validated the efficacy of HSAF against candidiasis caused by
in a murine model in vivo, and HSAF significantly improved survival and reduced fungal burden compared to vehicles. A molecular dynamics (MD) simulation was also investigated, revealing the theoretical binding mode of HSAF to the β-tubulin of
. This study first found PTMs-induced fungal apoptosis through ROS accumulation in
and its potential as a novel agent for fungicides. |
| doi_str_mv | 10.1039/c5ra26092b |
| format | Article |
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s (
). In this study, we found that HSAF induced the apoptosis of
s SC5314 through inducing the production of reactive oxygen species (ROS). Nevertheless, we validated the efficacy of HSAF against candidiasis caused by
in a murine model in vivo, and HSAF significantly improved survival and reduced fungal burden compared to vehicles. A molecular dynamics (MD) simulation was also investigated, revealing the theoretical binding mode of HSAF to the β-tubulin of
. This study first found PTMs-induced fungal apoptosis through ROS accumulation in
and its potential as a novel agent for fungicides.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/c5ra26092b</identifier><identifier>PMID: 27594989</identifier><language>eng</language><publisher>England</publisher><subject>animal models ; antifungal properties ; Apoptosis ; Binding ; Candida ; Candida albicans ; candidiasis ; Effectiveness ; Fungi ; Fungicides ; heat stability ; molecular dynamics ; Pathogens ; Survival ; tubulin</subject><ispartof>RSC advances, 2016-01, Vol.6 (37), p.30895-30904</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-7631f56872ea0f5963282285de8849d7d7eb0a1e9d119b503953894ffe79825e3</citedby><cites>FETCH-LOGICAL-c543t-7631f56872ea0f5963282285de8849d7d7eb0a1e9d119b503953894ffe79825e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27594989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Yanjiao</creatorcontrib><creatorcontrib>Li, Zhenyu</creatorcontrib><creatorcontrib>Li, Yaoyao</creatorcontrib><creatorcontrib>Lu, Chunhua</creatorcontrib><creatorcontrib>Wang, Haoxin</creatorcontrib><creatorcontrib>Shen, Yuemao</creatorcontrib><creatorcontrib>Du, Liangcheng</creatorcontrib><title>HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>Heat-stable antifungal factor (HSAF) belongs to polycyclic tetramate macrolactams (PTMs), which inhibits many fungal pathogens and is effective in inhibiting
s (
). In this study, we found that HSAF induced the apoptosis of
s SC5314 through inducing the production of reactive oxygen species (ROS). Nevertheless, we validated the efficacy of HSAF against candidiasis caused by
in a murine model in vivo, and HSAF significantly improved survival and reduced fungal burden compared to vehicles. A molecular dynamics (MD) simulation was also investigated, revealing the theoretical binding mode of HSAF to the β-tubulin of
. This study first found PTMs-induced fungal apoptosis through ROS accumulation in
and its potential as a novel agent for fungicides.</description><subject>animal models</subject><subject>antifungal properties</subject><subject>Apoptosis</subject><subject>Binding</subject><subject>Candida</subject><subject>Candida albicans</subject><subject>candidiasis</subject><subject>Effectiveness</subject><subject>Fungi</subject><subject>Fungicides</subject><subject>heat stability</subject><subject>molecular dynamics</subject><subject>Pathogens</subject><subject>Survival</subject><subject>tubulin</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkk1r3DAQhkVp6IZkL_kBxcdScCKNPPq4FLZLkxQWArvJWciWvKvilbeWHei_r9KkITklc5mBeeZlvgg5Y_ScUa4vGhwsCKqh_kCOgVaiBCr0xxfxjMxT-kWzCWQg2CcyA4m60kofk_X1ZnFZhuimxrvCxjG0U9zarvBt65sxFSEWSxtdcLawXR0aG1Mx7oZ-2u6K9c2m3HsX7PhQe-gPY59COiVHre2Snz_5E3J3-eN2eV2ubq5-LherssGKj6UUnLUolARvaYtacFAACp1XqtJOOulrapnXjjFdY54VudJVbktqBej5Cfn2qHuY6txF4-M42M4chrC3wx_T22BeZ2LYmW1_bzBvQlY8C3x5Ehj635NPo9mH1Pius9H3UzIAyEELFOJNlCmOQmoU1TtQqvIlpIK3UakQEJimGf36iDZDn9Lg2-c5GTUPj2CWuF78e4TvGf78cjPP6P-z87_qzKwZ</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Ding, Yanjiao</creator><creator>Li, Zhenyu</creator><creator>Li, Yaoyao</creator><creator>Lu, Chunhua</creator><creator>Wang, Haoxin</creator><creator>Shen, Yuemao</creator><creator>Du, Liangcheng</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis</title><author>Ding, Yanjiao ; Li, Zhenyu ; Li, Yaoyao ; Lu, Chunhua ; Wang, Haoxin ; Shen, Yuemao ; Du, Liangcheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-7631f56872ea0f5963282285de8849d7d7eb0a1e9d119b503953894ffe79825e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>animal models</topic><topic>antifungal properties</topic><topic>Apoptosis</topic><topic>Binding</topic><topic>Candida</topic><topic>Candida albicans</topic><topic>candidiasis</topic><topic>Effectiveness</topic><topic>Fungi</topic><topic>Fungicides</topic><topic>heat stability</topic><topic>molecular dynamics</topic><topic>Pathogens</topic><topic>Survival</topic><topic>tubulin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Yanjiao</creatorcontrib><creatorcontrib>Li, Zhenyu</creatorcontrib><creatorcontrib>Li, Yaoyao</creatorcontrib><creatorcontrib>Lu, Chunhua</creatorcontrib><creatorcontrib>Wang, Haoxin</creatorcontrib><creatorcontrib>Shen, Yuemao</creatorcontrib><creatorcontrib>Du, Liangcheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Yanjiao</au><au>Li, Zhenyu</au><au>Li, Yaoyao</au><au>Lu, Chunhua</au><au>Wang, Haoxin</au><au>Shen, Yuemao</au><au>Du, Liangcheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>6</volume><issue>37</issue><spage>30895</spage><epage>30904</epage><pages>30895-30904</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><abstract>Heat-stable antifungal factor (HSAF) belongs to polycyclic tetramate macrolactams (PTMs), which inhibits many fungal pathogens and is effective in inhibiting
s (
). In this study, we found that HSAF induced the apoptosis of
s SC5314 through inducing the production of reactive oxygen species (ROS). Nevertheless, we validated the efficacy of HSAF against candidiasis caused by
in a murine model in vivo, and HSAF significantly improved survival and reduced fungal burden compared to vehicles. A molecular dynamics (MD) simulation was also investigated, revealing the theoretical binding mode of HSAF to the β-tubulin of
. This study first found PTMs-induced fungal apoptosis through ROS accumulation in
and its potential as a novel agent for fungicides.</abstract><cop>England</cop><pmid>27594989</pmid><doi>10.1039/c5ra26092b</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2046-2069 |
| ispartof | RSC advances, 2016-01, Vol.6 (37), p.30895-30904 |
| issn | 2046-2069 2046-2069 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5006743 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | animal models antifungal properties Apoptosis Binding Candida Candida albicans candidiasis Effectiveness Fungi Fungicides heat stability molecular dynamics Pathogens Survival tubulin |
| title | HSAF-induced antifungal effects in Candida albicans through ROS-mediated apoptosis |
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