Characterization of Inflammatory Response in Acute-on-Chronic Liver Failure and Relationship with Prognosis
ACLF is characterized by a systemic inflammatory response, but the cytokines involved in this process have not been well studied. The aim of this study was to characterize the systemic inflammatory response in patients with cirrhosis and ACLF and its relationship with prognosis. Fifty-five patients...
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| Veröffentlicht in: | Scientific reports 2016-08, Vol.6 (1), p.32341-32341, Article 32341 |
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| creator | Solé, Cristina Solà, Elsa Morales-Ruiz, Manuel Fernàndez, Guerau Huelin, Patricia Graupera, Isabel Moreira, Rebeca de Prada, Gloria Ariza, Xavier Pose, Elisa Fabrellas, Núria Kalko, Susana G. Jiménez, Wladimiro Ginès, Pere |
| description | ACLF is characterized by a systemic inflammatory response, but the cytokines involved in this process have not been well studied. The aim of this study was to characterize the systemic inflammatory response in patients with cirrhosis and ACLF and its relationship with prognosis. Fifty-five patients with cirrhosis, 26 with ACLF, were studied prospectively. Systemic inflammatory response was analyzed by measuring a large array of plasma cytokines by using a multiplex kit. A principal component analysis show noticeable differences between ACLF and decompensated cirrhosis without ACLF. Patients with ACLF had significant abnormal levels of 12 cytokines compared to those without ACLF, including: VCAM-1, VEGF-A, Fractalkine, MIP-1α, Eotaxin, IP-10, RANTES, GM-CSF, IL-1β, IL-2, ICAM-1 and MCP-1. Cytokines showing the most marked relationship with ACLF were VCAM-1 and VEGF-A (AUCROC 0.77; p = 0.001). There was a significant relationship between some of inflammatory mediators and 3-month mortality, particularly VCAM-1, ICAM-1 and GM-CSF (AUCROC>0.7; p |
| doi_str_mv | 10.1038/srep32341 |
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The aim of this study was to characterize the systemic inflammatory response in patients with cirrhosis and ACLF and its relationship with prognosis. Fifty-five patients with cirrhosis, 26 with ACLF, were studied prospectively. Systemic inflammatory response was analyzed by measuring a large array of plasma cytokines by using a multiplex kit. A principal component analysis show noticeable differences between ACLF and decompensated cirrhosis without ACLF. Patients with ACLF had significant abnormal levels of 12 cytokines compared to those without ACLF, including: VCAM-1, VEGF-A, Fractalkine, MIP-1α, Eotaxin, IP-10, RANTES, GM-CSF, IL-1β, IL-2, ICAM-1 and MCP-1. Cytokines showing the most marked relationship with ACLF were VCAM-1 and VEGF-A (AUCROC 0.77; p = 0.001). There was a significant relationship between some of inflammatory mediators and 3-month mortality, particularly VCAM-1, ICAM-1 and GM-CSF (AUCROC>0.7; p < 0.05). Functional Enrichment Analysis showed that inflammatory markers differentially expressed in ACLF patients were enriched in leukocyte migration, particularly monocytes and macrophages and chemotaxis pathways. In conclusion, ACLF is characterized by a marked inflammatory reaction with activation of mediators of adhesion and migration of leukocytes. The intensity of the inflammatory reaction correlates with prognosis.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep32341</identifier><identifier>PMID: 27578545</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/4020/4021/1607/1604 ; 692/53/2422 ; Acute-On-Chronic Liver Failure - blood ; Acute-On-Chronic Liver Failure - physiopathology ; Biomarkers - blood ; Cell activation ; Cell Adhesion - genetics ; Cell Movement - genetics ; Chemotaxis ; Cirrhosis ; Cirrosi hepàtica ; Cytokines ; Cytokines - blood ; Eotaxin ; Female ; Fibrosis - blood ; Fibrosis - physiopathology ; Fractalkine ; Granulocyte-macrophage colony-stimulating factor ; Hepatic cirrhosis ; Humanities and Social Sciences ; Humans ; Inflamació ; Inflammation ; Inflammation - blood ; Inflammation - physiopathology ; Insuficiència hepàtica ; Intercellular adhesion molecule 1 ; Interleukin 2 ; IP-10 protein ; Leukocyte migration ; Liver cirrhosis ; Liver diseases ; Liver failure ; Macrophages ; Malalties del fetge ; Male ; Monocyte chemoattractant protein 1 ; Monocytes ; multidisciplinary ; Principal components analysis ; Prognosis ; Pronòstic mèdic ; RANTES ; Science ; Vascular cell adhesion molecule 1 ; Vascular endothelial growth factor</subject><ispartof>Scientific reports, 2016-08, Vol.6 (1), p.32341-32341, Article 32341</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Aug 2016</rights><rights>cc-by (c) Solé, Cristina et al., 2016 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a></rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-dde72a487da2c91f7d49db51ef2eac7791035377aae840248f96c351d30d45553</citedby><cites>FETCH-LOGICAL-c480t-dde72a487da2c91f7d49db51ef2eac7791035377aae840248f96c351d30d45553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006032/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006032/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,26951,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27578545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solé, Cristina</creatorcontrib><creatorcontrib>Solà, Elsa</creatorcontrib><creatorcontrib>Morales-Ruiz, Manuel</creatorcontrib><creatorcontrib>Fernàndez, Guerau</creatorcontrib><creatorcontrib>Huelin, Patricia</creatorcontrib><creatorcontrib>Graupera, Isabel</creatorcontrib><creatorcontrib>Moreira, Rebeca</creatorcontrib><creatorcontrib>de Prada, Gloria</creatorcontrib><creatorcontrib>Ariza, Xavier</creatorcontrib><creatorcontrib>Pose, Elisa</creatorcontrib><creatorcontrib>Fabrellas, Núria</creatorcontrib><creatorcontrib>Kalko, Susana G.</creatorcontrib><creatorcontrib>Jiménez, Wladimiro</creatorcontrib><creatorcontrib>Ginès, Pere</creatorcontrib><title>Characterization of Inflammatory Response in Acute-on-Chronic Liver Failure and Relationship with Prognosis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>ACLF is characterized by a systemic inflammatory response, but the cytokines involved in this process have not been well studied. The aim of this study was to characterize the systemic inflammatory response in patients with cirrhosis and ACLF and its relationship with prognosis. Fifty-five patients with cirrhosis, 26 with ACLF, were studied prospectively. Systemic inflammatory response was analyzed by measuring a large array of plasma cytokines by using a multiplex kit. A principal component analysis show noticeable differences between ACLF and decompensated cirrhosis without ACLF. Patients with ACLF had significant abnormal levels of 12 cytokines compared to those without ACLF, including: VCAM-1, VEGF-A, Fractalkine, MIP-1α, Eotaxin, IP-10, RANTES, GM-CSF, IL-1β, IL-2, ICAM-1 and MCP-1. Cytokines showing the most marked relationship with ACLF were VCAM-1 and VEGF-A (AUCROC 0.77; p = 0.001). There was a significant relationship between some of inflammatory mediators and 3-month mortality, particularly VCAM-1, ICAM-1 and GM-CSF (AUCROC>0.7; p < 0.05). Functional Enrichment Analysis showed that inflammatory markers differentially expressed in ACLF patients were enriched in leukocyte migration, particularly monocytes and macrophages and chemotaxis pathways. In conclusion, ACLF is characterized by a marked inflammatory reaction with activation of mediators of adhesion and migration of leukocytes. The intensity of the inflammatory reaction correlates with prognosis.</description><subject>692/4020/4021/1607/1604</subject><subject>692/53/2422</subject><subject>Acute-On-Chronic Liver Failure - blood</subject><subject>Acute-On-Chronic Liver Failure - physiopathology</subject><subject>Biomarkers - blood</subject><subject>Cell activation</subject><subject>Cell Adhesion - genetics</subject><subject>Cell Movement - genetics</subject><subject>Chemotaxis</subject><subject>Cirrhosis</subject><subject>Cirrosi hepàtica</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Eotaxin</subject><subject>Female</subject><subject>Fibrosis - blood</subject><subject>Fibrosis - physiopathology</subject><subject>Fractalkine</subject><subject>Granulocyte-macrophage colony-stimulating factor</subject><subject>Hepatic cirrhosis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Inflamació</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - physiopathology</subject><subject>Insuficiència hepàtica</subject><subject>Intercellular adhesion molecule 1</subject><subject>Interleukin 2</subject><subject>IP-10 protein</subject><subject>Leukocyte migration</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Liver failure</subject><subject>Macrophages</subject><subject>Malalties del fetge</subject><subject>Male</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Monocytes</subject><subject>multidisciplinary</subject><subject>Principal components analysis</subject><subject>Prognosis</subject><subject>Pronòstic mèdic</subject><subject>RANTES</subject><subject>Science</subject><subject>Vascular cell adhesion molecule 1</subject><subject>Vascular endothelial growth factor</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>XX2</sourceid><recordid>eNplkVFrFDEQx4Motpx98AtIwBcrrCbZZLN5EcphtXCgiD6HNJm9Td1N1mS3Uj-9ae88Tg2EJMxv_pOZP0LPKXlDSd2-zQmmmtWcPkKnjHBRsZqxx0f3E3SW8w0pSzDFqXqKTpgUshVcnKLv694kY2dI_peZfQw4dvgqdIMZRzPHdIe_QJ5iyIB9wBd2maGKoVr3KQZv8cbfQsKXxg9LAmyCK_jwoJN7P-Gffu7x5xS3IWafn6EnnRkynO3PFfp2-f7r-mO1-fThan2xqSxvyVw5B5IZ3kpnmFW0k44rdy0odAyMlVKVtkUtpTHQcsJ426nG1oK6mjguhKhX6N1Od1quR3AWwpzMoKfkR5PudDRe_x0JvtfbeKsFIQ0ps1whuhOwebE6gYVkzfyQeHjcb0Yk00zVjeQl59W-aIo_FsizHn22MAwmQFyypi0VSraEyoK-_Ae9iUsKZSSFUm3DGyJUoc73n0gxF5O7QwOU6Hvn9cH5wr447vhA_vG5AK93QC6hsIV0VPI_td_ykLjY</recordid><startdate>20160831</startdate><enddate>20160831</enddate><creator>Solé, Cristina</creator><creator>Solà, Elsa</creator><creator>Morales-Ruiz, Manuel</creator><creator>Fernàndez, Guerau</creator><creator>Huelin, Patricia</creator><creator>Graupera, Isabel</creator><creator>Moreira, Rebeca</creator><creator>de Prada, Gloria</creator><creator>Ariza, Xavier</creator><creator>Pose, Elisa</creator><creator>Fabrellas, Núria</creator><creator>Kalko, Susana G.</creator><creator>Jiménez, Wladimiro</creator><creator>Ginès, Pere</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>XX2</scope><scope>5PM</scope></search><sort><creationdate>20160831</creationdate><title>Characterization of Inflammatory Response in Acute-on-Chronic Liver Failure and Relationship with Prognosis</title><author>Solé, Cristina ; Solà, Elsa ; Morales-Ruiz, Manuel ; Fernàndez, Guerau ; Huelin, Patricia ; Graupera, Isabel ; Moreira, Rebeca ; de Prada, Gloria ; Ariza, Xavier ; Pose, Elisa ; Fabrellas, Núria ; Kalko, Susana G. ; Jiménez, Wladimiro ; Ginès, Pere</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-dde72a487da2c91f7d49db51ef2eac7791035377aae840248f96c351d30d45553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>692/4020/4021/1607/1604</topic><topic>692/53/2422</topic><topic>Acute-On-Chronic Liver Failure - blood</topic><topic>Acute-On-Chronic Liver Failure - physiopathology</topic><topic>Biomarkers - blood</topic><topic>Cell activation</topic><topic>Cell Adhesion - genetics</topic><topic>Cell Movement - genetics</topic><topic>Chemotaxis</topic><topic>Cirrhosis</topic><topic>Cirrosi hepàtica</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Eotaxin</topic><topic>Female</topic><topic>Fibrosis - blood</topic><topic>Fibrosis - physiopathology</topic><topic>Fractalkine</topic><topic>Granulocyte-macrophage colony-stimulating factor</topic><topic>Hepatic cirrhosis</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Inflamació</topic><topic>Inflammation</topic><topic>Inflammation - blood</topic><topic>Inflammation - physiopathology</topic><topic>Insuficiència hepàtica</topic><topic>Intercellular adhesion molecule 1</topic><topic>Interleukin 2</topic><topic>IP-10 protein</topic><topic>Leukocyte migration</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Liver failure</topic><topic>Macrophages</topic><topic>Malalties del fetge</topic><topic>Male</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Monocytes</topic><topic>multidisciplinary</topic><topic>Principal components analysis</topic><topic>Prognosis</topic><topic>Pronòstic mèdic</topic><topic>RANTES</topic><topic>Science</topic><topic>Vascular cell adhesion molecule 1</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solé, Cristina</creatorcontrib><creatorcontrib>Solà, Elsa</creatorcontrib><creatorcontrib>Morales-Ruiz, Manuel</creatorcontrib><creatorcontrib>Fernàndez, Guerau</creatorcontrib><creatorcontrib>Huelin, Patricia</creatorcontrib><creatorcontrib>Graupera, Isabel</creatorcontrib><creatorcontrib>Moreira, Rebeca</creatorcontrib><creatorcontrib>de Prada, Gloria</creatorcontrib><creatorcontrib>Ariza, Xavier</creatorcontrib><creatorcontrib>Pose, Elisa</creatorcontrib><creatorcontrib>Fabrellas, Núria</creatorcontrib><creatorcontrib>Kalko, Susana G.</creatorcontrib><creatorcontrib>Jiménez, Wladimiro</creatorcontrib><creatorcontrib>Ginès, Pere</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Recercat</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solé, Cristina</au><au>Solà, Elsa</au><au>Morales-Ruiz, Manuel</au><au>Fernàndez, Guerau</au><au>Huelin, Patricia</au><au>Graupera, Isabel</au><au>Moreira, Rebeca</au><au>de Prada, Gloria</au><au>Ariza, Xavier</au><au>Pose, Elisa</au><au>Fabrellas, Núria</au><au>Kalko, Susana G.</au><au>Jiménez, Wladimiro</au><au>Ginès, Pere</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Inflammatory Response in Acute-on-Chronic Liver Failure and Relationship with Prognosis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-08-31</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>32341</spage><epage>32341</epage><pages>32341-32341</pages><artnum>32341</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>ACLF is characterized by a systemic inflammatory response, but the cytokines involved in this process have not been well studied. The aim of this study was to characterize the systemic inflammatory response in patients with cirrhosis and ACLF and its relationship with prognosis. Fifty-five patients with cirrhosis, 26 with ACLF, were studied prospectively. Systemic inflammatory response was analyzed by measuring a large array of plasma cytokines by using a multiplex kit. A principal component analysis show noticeable differences between ACLF and decompensated cirrhosis without ACLF. Patients with ACLF had significant abnormal levels of 12 cytokines compared to those without ACLF, including: VCAM-1, VEGF-A, Fractalkine, MIP-1α, Eotaxin, IP-10, RANTES, GM-CSF, IL-1β, IL-2, ICAM-1 and MCP-1. Cytokines showing the most marked relationship with ACLF were VCAM-1 and VEGF-A (AUCROC 0.77; p = 0.001). There was a significant relationship between some of inflammatory mediators and 3-month mortality, particularly VCAM-1, ICAM-1 and GM-CSF (AUCROC>0.7; p < 0.05). Functional Enrichment Analysis showed that inflammatory markers differentially expressed in ACLF patients were enriched in leukocyte migration, particularly monocytes and macrophages and chemotaxis pathways. In conclusion, ACLF is characterized by a marked inflammatory reaction with activation of mediators of adhesion and migration of leukocytes. The intensity of the inflammatory reaction correlates with prognosis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27578545</pmid><doi>10.1038/srep32341</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/4020/4021/1607/1604 692/53/2422 Acute-On-Chronic Liver Failure - blood Acute-On-Chronic Liver Failure - physiopathology Biomarkers - blood Cell activation Cell Adhesion - genetics Cell Movement - genetics Chemotaxis Cirrhosis Cirrosi hepàtica Cytokines Cytokines - blood Eotaxin Female Fibrosis - blood Fibrosis - physiopathology Fractalkine Granulocyte-macrophage colony-stimulating factor Hepatic cirrhosis Humanities and Social Sciences Humans Inflamació Inflammation Inflammation - blood Inflammation - physiopathology Insuficiència hepàtica Intercellular adhesion molecule 1 Interleukin 2 IP-10 protein Leukocyte migration Liver cirrhosis Liver diseases Liver failure Macrophages Malalties del fetge Male Monocyte chemoattractant protein 1 Monocytes multidisciplinary Principal components analysis Prognosis Pronòstic mèdic RANTES Science Vascular cell adhesion molecule 1 Vascular endothelial growth factor |
| title | Characterization of Inflammatory Response in Acute-on-Chronic Liver Failure and Relationship with Prognosis |
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