Intrinsic self-DNA triggers inflammatory disease dependent on STING

Inflammatory diseases such as Aicardi-Goutières syndrome and severe systemic lupus erythematosus are generally lethal disorders that have been traced to defects in the exonuclease TREX1 (DNase III). Mice lacking TREX1 similarly die at an early age through comparable symptoms, including inflammatory...

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Veröffentlicht in:	The Journal of immunology (1950) 2014-11, Vol.193 (9), p.4634-4642
Hauptverfasser:	Ahn, Jeonghyun, Ruiz, Phillip, Barber, Glen N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Chemotaxis - genetics Chemotaxis - immunology Cluster Analysis Cytokines - genetics Cytokines - metabolism Disease Models, Animal Exodeoxyribonucleases - deficiency Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Gene Expression Profiling Inflammation - genetics Inflammation - immunology Inflammation - metabolism Inflammation - therapy Inflammation Mediators - metabolism Leukocytes - immunology Leukocytes - metabolism Leukocytes - pathology Macrophages - immunology Macrophages - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Monocytes - immunology Monocytes - metabolism Myocardium - immunology Myocardium - metabolism Myocardium - pathology Phagocytes - immunology Phagocytes - metabolism Phosphoproteins - deficiency Phosphoproteins - genetics Phosphoproteins - metabolism Signal Transduction
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