RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation

The activation of retinoic acid-inducible gene 1 (RIG-I), a cytoplasmic innate sensor for viral RNA, is tightly regulated to maintain immune homeostasis properly and prevent excessive inflammatory reactions other than initiation of antiviral innate response to eliminate RNA virus effectively. Posttr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-08, Vol.113 (34), p.9581-9586
Hauptverfasser:	Wang, Wendie, Jiang, Minghong, Liu, Shuo, Zhang, Shikun, Liu, Wei, Ma, Yuanwu, Zhang, Lianfeng, Zhang, Jiyan, Cao, Xuetao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cytoplasm Gene Expression Regulation Homeostasis Immunity, Innate Interferon Interferon Type I - antagonists & inhibitors Interferon Type I - biosynthesis Interferon Type I - immunology Macrophages - immunology Macrophages - virology Membrane Proteins - genetics Membrane Proteins - immunology Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology Proteasome Endopeptidase Complex - metabolism Protein Interaction Domains and Motifs Proteins Proteolysis Ribonucleic acid RNA RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Sendai virus - growth & development Sendai virus - immunology Signal Transduction Ubiquitin-Protein Ligases - antagonists & inhibitors Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Vesiculovirus - growth & development Vesiculovirus - immunology Viruses
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