Association between functional small airway disease and FEV1 decline in chronic obstructive pulmonary disease

The small conducting airways are the major site of airflow obstruction in chronic obstructive pulmonary disease and may precede emphysema development. We hypothesized a novel computed tomography (CT) biomarker of small airway disease predicts FEV1 decline. We analyzed 1,508 current and former smoker...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2016-07, Vol.194 (2), p.178-184, Article 178
Hauptverfasser:	Bhatt, Surya P, Soler, Xavier, Wang, Xin, Murray, Susan, Anzueto, Antonio R, Beaty, Terri H, Boriek, Aladin M, Casaburi, Richard, Criner, Gerard J, Diaz, Alejandro A, Dransfield, Mark T, Curran-Everett, Douglas, Galbán, Craig J, Hoffman, Eric A, Hogg, James C, Kazerooni, Ella A, Kim, Victor, Kinney, Gregory L, Lagstein, Amir, Lynch, David A, Make, Barry J, Martinez, Fernando J, Ramsdell, Joe W, Reddy, Rishindra, Ross, Brian D, Rossiter, Harry B, Steiner, Robert M, Strand, Matthew J, van Beek, Edwin J R, Wan, Emily S, Washko, George R, Wells, J Michael, Wendt, Chris H, Wise, Robert A, Silverman, Edwin K, Crapo, James D, Bowler, Russell P, Han, MeiLan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Female Forced Expiratory Volume - physiology Humans Lung - diagnostic imaging Lung - physiopathology Male Middle Aged Original Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - physiopathology Respiratory System - diagnostic imaging Respiratory System - physiopathology Spirometry Tomography, X-Ray Computed
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