Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

Stable retention of BRCA1/BARD1 complexes at sites of DNA damage is required for the proper response to DNA double-strand breaks (DSB). Here, we demonstrate that the BRCT domain of BARD1 is crucial for its retention through interaction with HP1. In response to DNA damage, BARD1 interacts with Lys9-d...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-04, Vol.75 (7), p.1311-1321
Hauptverfasser:	Wu, Wenwen, Nishikawa, Hiroyuki, Fukuda, Takayo, Vittal, Vinayak, Asano, Masahide, Miyoshi, Yasuo, Klevit, Rachel E, Ohta, Tomohiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs BRCA1 Protein - metabolism Cell Line, Tumor Chromosomal Proteins, Non-Histone - metabolism DNA Damage DNA Repair HEK293 Cells Histones Humans Protein Interaction Domains and Motifs Protein Transport Tumor Suppressor Proteins - metabolism Ubiquitin-Protein Ligases - metabolism
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