YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression

Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) and culminates with enhanced cell survival. This stress response program relies on a subset tiRNAs that inhibit translation initiation...

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Veröffentlicht in:	Nucleic acids research 2016-08, Vol.44 (14), p.6949-6960
Hauptverfasser:	Lyons, Shawn M, Achorn, Chris, Kedersha, Nancy L, Anderson, Paul J, Ivanov, Pavel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Arsenites - pharmacology Base Sequence Cell Proliferation Cell Survival CRISPR-Cas Systems - genetics Cytoplasmic Granules - drug effects Cytoplasmic Granules - metabolism Eukaryotic Initiation Factor-4F - metabolism Gene Deletion Gene Knockout Techniques Genetic Heterogeneity Humans MCF-7 Cells Models, Molecular Protein Biosynthesis - drug effects RNA RNA, Guide, CRISPR-Cas Systems - metabolism RNA, Transfer - genetics RNA, Transfer - metabolism Sodium Compounds - pharmacology Stress, Physiological - drug effects Y-Box-Binding Protein 1 - chemistry Y-Box-Binding Protein 1 - genetics Y-Box-Binding Protein 1 - metabolism
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