Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling

By proteomics analysis of conditioned media from cells with constitutive mTORC1 activity, Yu and colleagues identify IGF binding protein 5 (IGFBP5) as a protein that is induced by mTORC1 through HIF1 and that blocks IGF-1 signalling. The PI(3)K–Akt–mTORC1 pathway is a highly dynamic network that is...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature cell biology 2016-03, Vol.18 (3), p.319-327
Hauptverfasser:	Ding, Ming, Bruick, Richard K., Yu, Yonghao
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 13/89 13/95 42/70 631/80/86 631/80/86/820 82/58 96/106 Animals Binding proteins Cancer Research Carrier Proteins - metabolism Cell Biology Cells, Cultured Cellular signal transduction Developmental Biology Genetic aspects Growth factors Health aspects Humans Insulin-Like Growth Factor I - metabolism letter Life Sciences Mechanistic Target of Rapamycin Complex 1 Mice Mice, Knockout Multiprotein Complexes - metabolism Properties Proteomics - methods Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects Signal Transduction - physiology Sirolimus - pharmacology Stem Cells TOR Serine-Threonine Kinases - metabolism Transcription factors Transcription Factors - metabolism Tumor Suppressor Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!