Propofol anesthesia induces proapoptotic tumor necrosis factor-α and pro-nerve growth factor signaling and prosurvival Akt and XIAP expression in neonatal rat brain

Previously we observed that prolonged exposure to propofol anesthesia causes caspase‐3‐ and calpain‐mediated neuronal death in the developing brain. The present study examines the effects of propofol anesthesia on the expression of tumor necrosis factor‐α (TNFα), pro‐nerve growth factor (NGF), and t...

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Veröffentlicht in:	Journal of neuroscience research 2014-10, Vol.92 (10), p.1362-1373
Hauptverfasser:	Milanović, Desanka, Pešić, Vesna, Popić, Jelena, Tanić, Nikola, Kanazir, Selma, Jevtović-Todorović, Vesna, Ruždijić, Sabera
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Anesthetics, Intravenous - pharmacology Animals Animals, Newborn Brain - drug effects Brain - growth & development Gene Expression Regulation - drug effects Male neonatal rat Nerve Growth Factor - metabolism neurotoxicity Oncogene Protein v-akt - metabolism Propofol - pharmacology propofol anesthesia prosurvival proteins Rats Rats, Wistar Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects Tumor Necrosis Factor-alpha - metabolism X-Linked Inhibitor of Apoptosis Protein - metabolism
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