The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults
The prevalence of dyslipidemia in China was increased over the last several years. Studies have shown that the activity of aBAT is related to the lipid metabolism. In this study, we analyzed blood lipid level in tumor-free healthy Chinese adults in order to determine the role of aBAT in lipid metabo...
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| Veröffentlicht in: | Lipids in health and disease 2016-08, Vol.15 (1), p.138-138, Article 138 |
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| creator | Shao, Xiaoliang Yang, Wei Shao, Xiaonan Qiu, Chun Wang, Xiaosong Wang, Yuetao |
| description | The prevalence of dyslipidemia in China was increased over the last several years. Studies have shown that the activity of aBAT is related to the lipid metabolism. In this study, we analyzed blood lipid level in tumor-free healthy Chinese adults in order to determine the role of aBAT in lipid metabolism.
We retrospectively analyzed the factors that affect the blood lipid level in 717 tumor-free healthy adults who received blood lipid measurement and PET/CT scan by multivariate regression analysis. We also determined the role of aBAT on lipid profile by case-control study.
(1) Our results showed that 411 (57.3 %) subjects had dyslipidemia. The prevalence of the subjects with hypercholesteremia, hypertriglyceridemia, low high-density lipoprotein cholesterol and high low-density lipoprotein cholesterol was 9.5 %, 44.4 %, 30.8 % and 1.4 %, respectively. Multivariate logistic regression analysis with dyslipidemia as the dependent variable showed that body mass index (BMI) and smoking are independent risk factors for dyslipidemia (OR > 1, P |
| doi_str_mv | 10.1186/s12944-016-0310-8 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5000508</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A462473097</galeid><sourcerecordid>A462473097</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-d5a231e8b2f5efe52ef03af6abe4ad240181243a1648efe95841e02b2ed3c9943</originalsourceid><addsrcrecordid>eNptkUtr3DAUhUVpadK0P6CbIugmXTjR1cv2pjAZ-oJANlPooiBk-ypWka2pZafk30dm0pBA0ELi3u8cjjiEvAd2BlDp8wS8lrJgoAsmgBXVC3IMstSFAvj18tH7iLxJ6Q9jnJVavyZHvFRa61Iek9-7HukUA9LoqG1nf4O0meK_kdrO72NCOvuUFqSn9mKz-0T9SIPf-44OONsmBp-GddajDXN_S7e9HzGLbLeEOb0lr5wNCd_d3yfk59cvu-334vLq24_t5rJopdZz0SnLBWDVcKfQoeLomLBO2wal7bhkUAGXwoKWVd7XqpKAjDccO9HWtRQn5PPBd780A3YtjvNkg9lPfrDTrYnWm6eb0ffmOt4YxRhTrMoGp_cGU_y7YJrN4FOLIdgR45JMDqCEVhJ4Rj8e0Gsb0PjRxezYrrjZSM1lKVhdZursGSqfDgffxhGdz_MnAjgI2immNKF7SA_MrGWbQ9kml23Wss2a-sPjbz8o_rcr7gBnh6Sz</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1815365412</pqid></control><display><type>article</type><title>The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><creator>Shao, Xiaoliang ; Yang, Wei ; Shao, Xiaonan ; Qiu, Chun ; Wang, Xiaosong ; Wang, Yuetao</creator><creatorcontrib>Shao, Xiaoliang ; Yang, Wei ; Shao, Xiaonan ; Qiu, Chun ; Wang, Xiaosong ; Wang, Yuetao</creatorcontrib><description>The prevalence of dyslipidemia in China was increased over the last several years. Studies have shown that the activity of aBAT is related to the lipid metabolism. In this study, we analyzed blood lipid level in tumor-free healthy Chinese adults in order to determine the role of aBAT in lipid metabolism.
We retrospectively analyzed the factors that affect the blood lipid level in 717 tumor-free healthy adults who received blood lipid measurement and PET/CT scan by multivariate regression analysis. We also determined the role of aBAT on lipid profile by case-control study.
(1) Our results showed that 411 (57.3 %) subjects had dyslipidemia. The prevalence of the subjects with hypercholesteremia, hypertriglyceridemia, low high-density lipoprotein cholesterol and high low-density lipoprotein cholesterol was 9.5 %, 44.4 %, 30.8 % and 1.4 %, respectively. Multivariate logistic regression analysis with dyslipidemia as the dependent variable showed that body mass index (BMI) and smoking are independent risk factors for dyslipidemia (OR > 1, P < 0.05), while the presence of aBAT is the independent protective factor for dyslipidemia (OR < 1, P < 0.05). (2) The incidence of aBAT was 1.81 %. Subjects with aBAT had significantly lower serum triglyceride and higher serum high-density lipoprotein cholesterol than the subjects without aBAT. The serum total cholesterol and low-density lipoprotein cholesterol were not significantly different between the subjects with aBAT and those without aBAT.
Dyslipidemia is caused by multiple factors and the presence of aBAT is a protective factor for dyslipidemia in healthy Chinese adults.</description><identifier>ISSN: 1476-511X</identifier><identifier>EISSN: 1476-511X</identifier><identifier>DOI: 10.1186/s12944-016-0310-8</identifier><identifier>PMID: 27566674</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adipose Tissue, Brown - diagnostic imaging ; Adipose Tissue, Brown - metabolism ; Adipose Tissue, Brown - physiopathology ; Adult ; Adults ; Analysis ; Asian Continental Ancestry Group ; Atherosclerosis ; Care and treatment ; Complications and side effects ; Dyslipidemias ; Dyslipidemias - epidemiology ; Dyslipidemias - physiopathology ; Female ; Health aspects ; Humans ; Lipid Metabolism ; Male ; Middle Aged ; Prevalence ; Retrospective Studies ; Risk Factors</subject><ispartof>Lipids in health and disease, 2016-08, Vol.15 (1), p.138-138, Article 138</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-d5a231e8b2f5efe52ef03af6abe4ad240181243a1648efe95841e02b2ed3c9943</citedby><cites>FETCH-LOGICAL-c466t-d5a231e8b2f5efe52ef03af6abe4ad240181243a1648efe95841e02b2ed3c9943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000508/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000508/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27566674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shao, Xiaoliang</creatorcontrib><creatorcontrib>Yang, Wei</creatorcontrib><creatorcontrib>Shao, Xiaonan</creatorcontrib><creatorcontrib>Qiu, Chun</creatorcontrib><creatorcontrib>Wang, Xiaosong</creatorcontrib><creatorcontrib>Wang, Yuetao</creatorcontrib><title>The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults</title><title>Lipids in health and disease</title><addtitle>Lipids Health Dis</addtitle><description>The prevalence of dyslipidemia in China was increased over the last several years. Studies have shown that the activity of aBAT is related to the lipid metabolism. In this study, we analyzed blood lipid level in tumor-free healthy Chinese adults in order to determine the role of aBAT in lipid metabolism.
We retrospectively analyzed the factors that affect the blood lipid level in 717 tumor-free healthy adults who received blood lipid measurement and PET/CT scan by multivariate regression analysis. We also determined the role of aBAT on lipid profile by case-control study.
(1) Our results showed that 411 (57.3 %) subjects had dyslipidemia. The prevalence of the subjects with hypercholesteremia, hypertriglyceridemia, low high-density lipoprotein cholesterol and high low-density lipoprotein cholesterol was 9.5 %, 44.4 %, 30.8 % and 1.4 %, respectively. Multivariate logistic regression analysis with dyslipidemia as the dependent variable showed that body mass index (BMI) and smoking are independent risk factors for dyslipidemia (OR > 1, P < 0.05), while the presence of aBAT is the independent protective factor for dyslipidemia (OR < 1, P < 0.05). (2) The incidence of aBAT was 1.81 %. Subjects with aBAT had significantly lower serum triglyceride and higher serum high-density lipoprotein cholesterol than the subjects without aBAT. The serum total cholesterol and low-density lipoprotein cholesterol were not significantly different between the subjects with aBAT and those without aBAT.
Dyslipidemia is caused by multiple factors and the presence of aBAT is a protective factor for dyslipidemia in healthy Chinese adults.</description><subject>Adipose Tissue, Brown - diagnostic imaging</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Adipose Tissue, Brown - physiopathology</subject><subject>Adult</subject><subject>Adults</subject><subject>Analysis</subject><subject>Asian Continental Ancestry Group</subject><subject>Atherosclerosis</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Dyslipidemias</subject><subject>Dyslipidemias - epidemiology</subject><subject>Dyslipidemias - physiopathology</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>1476-511X</issn><issn>1476-511X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUtr3DAUhUVpadK0P6CbIugmXTjR1cv2pjAZ-oJANlPooiBk-ypWka2pZafk30dm0pBA0ELi3u8cjjiEvAd2BlDp8wS8lrJgoAsmgBXVC3IMstSFAvj18tH7iLxJ6Q9jnJVavyZHvFRa61Iek9-7HukUA9LoqG1nf4O0meK_kdrO72NCOvuUFqSn9mKz-0T9SIPf-44OONsmBp-GddajDXN_S7e9HzGLbLeEOb0lr5wNCd_d3yfk59cvu-334vLq24_t5rJopdZz0SnLBWDVcKfQoeLomLBO2wal7bhkUAGXwoKWVd7XqpKAjDccO9HWtRQn5PPBd780A3YtjvNkg9lPfrDTrYnWm6eb0ffmOt4YxRhTrMoGp_cGU_y7YJrN4FOLIdgR45JMDqCEVhJ4Rj8e0Gsb0PjRxezYrrjZSM1lKVhdZursGSqfDgffxhGdz_MnAjgI2immNKF7SA_MrGWbQ9kml23Wss2a-sPjbz8o_rcr7gBnh6Sz</recordid><startdate>20160826</startdate><enddate>20160826</enddate><creator>Shao, Xiaoliang</creator><creator>Yang, Wei</creator><creator>Shao, Xiaonan</creator><creator>Qiu, Chun</creator><creator>Wang, Xiaosong</creator><creator>Wang, Yuetao</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160826</creationdate><title>The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults</title><author>Shao, Xiaoliang ; Yang, Wei ; Shao, Xiaonan ; Qiu, Chun ; Wang, Xiaosong ; Wang, Yuetao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-d5a231e8b2f5efe52ef03af6abe4ad240181243a1648efe95841e02b2ed3c9943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adipose Tissue, Brown - diagnostic imaging</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Adipose Tissue, Brown - physiopathology</topic><topic>Adult</topic><topic>Adults</topic><topic>Analysis</topic><topic>Asian Continental Ancestry Group</topic><topic>Atherosclerosis</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Dyslipidemias</topic><topic>Dyslipidemias - epidemiology</topic><topic>Dyslipidemias - physiopathology</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lipid Metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shao, Xiaoliang</creatorcontrib><creatorcontrib>Yang, Wei</creatorcontrib><creatorcontrib>Shao, Xiaonan</creatorcontrib><creatorcontrib>Qiu, Chun</creatorcontrib><creatorcontrib>Wang, Xiaosong</creatorcontrib><creatorcontrib>Wang, Yuetao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Lipids in health and disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shao, Xiaoliang</au><au>Yang, Wei</au><au>Shao, Xiaonan</au><au>Qiu, Chun</au><au>Wang, Xiaosong</au><au>Wang, Yuetao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults</atitle><jtitle>Lipids in health and disease</jtitle><addtitle>Lipids Health Dis</addtitle><date>2016-08-26</date><risdate>2016</risdate><volume>15</volume><issue>1</issue><spage>138</spage><epage>138</epage><pages>138-138</pages><artnum>138</artnum><issn>1476-511X</issn><eissn>1476-511X</eissn><abstract>The prevalence of dyslipidemia in China was increased over the last several years. Studies have shown that the activity of aBAT is related to the lipid metabolism. In this study, we analyzed blood lipid level in tumor-free healthy Chinese adults in order to determine the role of aBAT in lipid metabolism.
We retrospectively analyzed the factors that affect the blood lipid level in 717 tumor-free healthy adults who received blood lipid measurement and PET/CT scan by multivariate regression analysis. We also determined the role of aBAT on lipid profile by case-control study.
(1) Our results showed that 411 (57.3 %) subjects had dyslipidemia. The prevalence of the subjects with hypercholesteremia, hypertriglyceridemia, low high-density lipoprotein cholesterol and high low-density lipoprotein cholesterol was 9.5 %, 44.4 %, 30.8 % and 1.4 %, respectively. Multivariate logistic regression analysis with dyslipidemia as the dependent variable showed that body mass index (BMI) and smoking are independent risk factors for dyslipidemia (OR > 1, P < 0.05), while the presence of aBAT is the independent protective factor for dyslipidemia (OR < 1, P < 0.05). (2) The incidence of aBAT was 1.81 %. Subjects with aBAT had significantly lower serum triglyceride and higher serum high-density lipoprotein cholesterol than the subjects without aBAT. The serum total cholesterol and low-density lipoprotein cholesterol were not significantly different between the subjects with aBAT and those without aBAT.
Dyslipidemia is caused by multiple factors and the presence of aBAT is a protective factor for dyslipidemia in healthy Chinese adults.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27566674</pmid><doi>10.1186/s12944-016-0310-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue, Brown - diagnostic imaging Adipose Tissue, Brown - metabolism Adipose Tissue, Brown - physiopathology Adult Adults Analysis Asian Continental Ancestry Group Atherosclerosis Care and treatment Complications and side effects Dyslipidemias Dyslipidemias - epidemiology Dyslipidemias - physiopathology Female Health aspects Humans Lipid Metabolism Male Middle Aged Prevalence Retrospective Studies Risk Factors |
| title | The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults |
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