Functional Human α7 Nicotinic Acetylcholine Receptor (nAChR) Generated from Escherichia coli

Human Cys-loop receptors are important therapeutic targets. High-resolution structures are essential for rational drug design, but only a few are available due to difficulties in obtaining sufficient quantities of protein suitable for structural studies. Although expression of proteins in E. coli of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2016-08, Vol.291 (35), p.18276-18282
Hauptverfasser:	Tillman, Tommy S., Alvarez, Frances J.D., Reinert, Nathan J., Liu, Chuang, Wang, Dawei, Xu, Yan, Xiao, Kunhong, Zhang, Peijun, Tang, Pei
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha7 Nicotinic Acetylcholine Receptor - biosynthesis alpha7 Nicotinic Acetylcholine Receptor - chemistry alpha7 Nicotinic Acetylcholine Receptor - genetics alpha7 Nicotinic Acetylcholine Receptor - isolation & purification Animals Bungarotoxins - chemistry Bungarotoxins - pharmacology Cys-loop receptor electron microscopy (EM) Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - biosynthesis Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Humans ion channel Isoxazoles - chemistry Isoxazoles - pharmacology Lidocaine - analogs & derivatives Lidocaine - chemistry Lidocaine - pharmacology Molecular Chaperones - biosynthesis Molecular Chaperones - chemistry Molecular Chaperones - genetics Neurobiology nicotinic acetylcholine receptors (nAChR) pentameric ligand-gated ion channels Phencyclidine - chemistry Phencyclidine - pharmacology Phenylurea Compounds - chemistry Phenylurea Compounds - pharmacology pLGICs recombinant protein expression Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - isolation & purification Xenopus α7 nAChR α7nAChR
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!