Risk factors for distant metastasis of dermatofibrosarcoma protuberans
Background Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports...
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| Veröffentlicht in: | Journal of orthopaedics and traumatology 2016-09, Vol.17 (3), p.261-266 |
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| creator | Hayakawa, Keiko Matsumoto, Seiichi Ae, Keisuke Tanizawa, Taisuke Gokita, Tabu Funauchi, Yuki Motoi, Noriko |
| description | Background
Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis.
Patients and methods
This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis.
Results
Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test:
p
= 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test:
p
|
| doi_str_mv | 10.1007/s10195-016-0415-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4999380</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1819142934</sourcerecordid><originalsourceid>FETCH-LOGICAL-c569t-681b3f0afb96e1c2de7b57f6fcd9dc43825a5c4122ef9cc96ba24955747818473</originalsourceid><addsrcrecordid>eNqNkU9LxDAQxYMorv8-gBcpePFSzaRJ2lwEWVwVBEH0HNI00eq2WZNU1m9vdHVZBcFcMjC_eZO8h9A-4GPAuDwJgEGwHAPPMQWWz9fQFjCBc5HO-rImMELbITxhDCUTfBONSEkqQXm1hSa3bXjOrNLR-ZBZ57OmDVH1MetMVKkKbciczRrjOxWdbWvvgvLadSqbeReH2njVh120YdU0mL2vewfdT87vxpf59c3F1fjsOteMi5jzCurCYmVrwQ1o0piyZqXlVjei0bSoCFNMUyDEWKG14LUiVDBW0rKCipbFDjpd6M6GujONNn30aipnvu2Uf5NOtfJnp28f5YN7lTQ5UlQ4CRx9CXj3MpgQZdcGbaZT1Rs3BAkVCKBEFPQ_aLKQwid6-At9coPvkxOfFOZUYJYoWFA6eRi8sct3A5YfgcpFoDIFKj8ClfM0c7D64eXEd4IJIAsgpFb_YPzK6j9V3wG1wK0H</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1814064905</pqid></control><display><type>article</type><title>Risk factors for distant metastasis of dermatofibrosarcoma protuberans</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hayakawa, Keiko ; Matsumoto, Seiichi ; Ae, Keisuke ; Tanizawa, Taisuke ; Gokita, Tabu ; Funauchi, Yuki ; Motoi, Noriko</creator><creatorcontrib>Hayakawa, Keiko ; Matsumoto, Seiichi ; Ae, Keisuke ; Tanizawa, Taisuke ; Gokita, Tabu ; Funauchi, Yuki ; Motoi, Noriko</creatorcontrib><description>Background
Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis.
Patients and methods
This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis.
Results
Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test:
p
= 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test:
p
< 0.0001).
Conclusions
In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important.
Level of evidence
V.</description><identifier>ISSN: 1590-9921</identifier><identifier>EISSN: 1590-9999</identifier><identifier>DOI: 10.1007/s10195-016-0415-x</identifier><identifier>PMID: 27289468</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adolescent ; Adult ; Aged ; Child ; Conservative Orthopedics ; Dermatofibrosarcoma - pathology ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Metastasis - pathology ; Neoplasm Recurrence, Local ; Original ; Original Article ; Orthopedics ; Prognosis ; Retrospective Studies ; Rheumatology ; Risk Factors ; Sports Medicine ; Surgical Orthopedics ; Time Factors ; Traumatic Surgery</subject><ispartof>Journal of orthopaedics and traumatology, 2016-09, Vol.17 (3), p.261-266</ispartof><rights>The Author(s) 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-681b3f0afb96e1c2de7b57f6fcd9dc43825a5c4122ef9cc96ba24955747818473</citedby><cites>FETCH-LOGICAL-c569t-681b3f0afb96e1c2de7b57f6fcd9dc43825a5c4122ef9cc96ba24955747818473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999380/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999380/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,41487,42188,42556,51318,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27289468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hayakawa, Keiko</creatorcontrib><creatorcontrib>Matsumoto, Seiichi</creatorcontrib><creatorcontrib>Ae, Keisuke</creatorcontrib><creatorcontrib>Tanizawa, Taisuke</creatorcontrib><creatorcontrib>Gokita, Tabu</creatorcontrib><creatorcontrib>Funauchi, Yuki</creatorcontrib><creatorcontrib>Motoi, Noriko</creatorcontrib><title>Risk factors for distant metastasis of dermatofibrosarcoma protuberans</title><title>Journal of orthopaedics and traumatology</title><addtitle>J Orthopaed Traumatol</addtitle><addtitle>J Orthop Traumatol</addtitle><description>Background
Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis.
Patients and methods
This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis.
Results
Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test:
p
= 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test:
p
< 0.0001).
Conclusions
In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important.
Level of evidence
V.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Child</subject><subject>Conservative Orthopedics</subject><subject>Dermatofibrosarcoma - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis - pathology</subject><subject>Neoplasm Recurrence, Local</subject><subject>Original</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Rheumatology</subject><subject>Risk Factors</subject><subject>Sports Medicine</subject><subject>Surgical Orthopedics</subject><subject>Time Factors</subject><subject>Traumatic Surgery</subject><issn>1590-9921</issn><issn>1590-9999</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkU9LxDAQxYMorv8-gBcpePFSzaRJ2lwEWVwVBEH0HNI00eq2WZNU1m9vdHVZBcFcMjC_eZO8h9A-4GPAuDwJgEGwHAPPMQWWz9fQFjCBc5HO-rImMELbITxhDCUTfBONSEkqQXm1hSa3bXjOrNLR-ZBZ57OmDVH1MetMVKkKbciczRrjOxWdbWvvgvLadSqbeReH2njVh120YdU0mL2vewfdT87vxpf59c3F1fjsOteMi5jzCurCYmVrwQ1o0piyZqXlVjei0bSoCFNMUyDEWKG14LUiVDBW0rKCipbFDjpd6M6GujONNn30aipnvu2Uf5NOtfJnp28f5YN7lTQ5UlQ4CRx9CXj3MpgQZdcGbaZT1Rs3BAkVCKBEFPQ_aLKQwid6-At9coPvkxOfFOZUYJYoWFA6eRi8sct3A5YfgcpFoDIFKj8ClfM0c7D64eXEd4IJIAsgpFb_YPzK6j9V3wG1wK0H</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Hayakawa, Keiko</creator><creator>Matsumoto, Seiichi</creator><creator>Ae, Keisuke</creator><creator>Tanizawa, Taisuke</creator><creator>Gokita, Tabu</creator><creator>Funauchi, Yuki</creator><creator>Motoi, Noriko</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160901</creationdate><title>Risk factors for distant metastasis of dermatofibrosarcoma protuberans</title><author>Hayakawa, Keiko ; 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Dermatofibrosarcoma protuberans (DFSP) may recur locally but rarely metastasizes. Fibrosarcomatous transformation in dermatofibrosarcoma protuberans (FS-DFSP) is said to have worse prognosis compared with ordinary DFSP (O-DFSP). Since DFSP rarely metastasizes, there have been few reports summarizing data on distant metastasis cases at single institution. The aim of this retrospective study is to review DFSP cases in order to analyze risk factors for metastasis.
Patients and methods
This retrospective study involved 67 patients. We analyzed O-DFSP and FS-DFSP metastasis rates, metastasis sites, time to metastasis, the relationship between frequency of local recurrence and metastasis, and the relationship between primary tumor size and metastasis.
Results
Distant metastasis was found in 5 (7.4 %) of 67 cases with DFSP. Of the five cases, the histopathological diagnosis was FS-DFSP in four cases and O-DFSP in one case. Out of five cases with metastasis, three had not recurred and two had recurred twice. No clear correlation was identified (Fisher’s exact test:
p
= 0.216). The primary tumor diameters in the metastatic cases were 15.0, 12.6, 20.5, 13.0, and 5.0 cm, respectively. The tumor diameters in metastatic cases were significantly larger (Fisher’s exact test:
p
< 0.0001).
Conclusions
In this study, we identified a stronger correlation between DFSP metastasis and tumor size. There was a high possibility that the cases with large tumors might be FS-DFSP, having high rate of metastasis and poor prognosis. In treatment of DFSP, early diagnosis before primary tumor growth and wide resection is considered important.
Level of evidence
V.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>27289468</pmid><doi>10.1007/s10195-016-0415-x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Child Conservative Orthopedics Dermatofibrosarcoma - pathology Female Humans Male Medicine Medicine & Public Health Middle Aged Neoplasm Metastasis - pathology Neoplasm Recurrence, Local Original Original Article Orthopedics Prognosis Retrospective Studies Rheumatology Risk Factors Sports Medicine Surgical Orthopedics Time Factors Traumatic Surgery |
| title | Risk factors for distant metastasis of dermatofibrosarcoma protuberans |
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