Nuclear Lamins in Cancer
Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies have separately demonstrated the importance of microenvironment mechanics to cancer progression, which is extremely in...
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| Veröffentlicht in: | Cellular and molecular bioengineering 2016-06, Vol.9 (2), p.258-267 |
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| creator | Irianto, Jerome Pfeifer, Charlotte R. Ivanovska, Irena L. Swift, Joe Discher, Dennis E. |
| description | Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies have separately demonstrated the importance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating cancer progression to lamina biophysics and biology. Lamin levels can modulate cancer cell migration in 3D and thereby impact tumor growth, and lamins can also protect or not a cancer cell’s genome. In addition, lamins can influence transcriptional regulators (RAR, SRF, YAP/TAZ) as well as chromosome conformation in lamina associated domains. Further investigation of the roles for lamins in cancer and even DNA damage may lead to new therapies or at least to a clearer understanding of lamins as bio-markers in cancer progression. |
| doi_str_mv | 10.1007/s12195-016-0437-8 |
| format | Article |
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Past studies have separately demonstrated the importance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating cancer progression to lamina biophysics and biology. Lamin levels can modulate cancer cell migration in 3D and thereby impact tumor growth, and lamins can also protect or not a cancer cell’s genome. In addition, lamins can influence transcriptional regulators (RAR, SRF, YAP/TAZ) as well as chromosome conformation in lamina associated domains. Further investigation of the roles for lamins in cancer and even DNA damage may lead to new therapies or at least to a clearer understanding of lamins as bio-markers in cancer progression.</description><identifier>ISSN: 1865-5025</identifier><identifier>EISSN: 1865-5033</identifier><identifier>DOI: 10.1007/s12195-016-0437-8</identifier><identifier>PMID: 27570565</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bioengineering ; Biological and Medical Physics ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical Engineering/Biotechnology ; Biophysics ; Cancer ; Cell Biology ; Cellular ; DNA damage ; Engineering ; Genomes ; Homeostasis ; Laminates ; Nuclei ; Progressions ; Signal transduction ; Therapy ; Three dimensional ; Transcription factors</subject><ispartof>Cellular and molecular bioengineering, 2016-06, Vol.9 (2), p.258-267</ispartof><rights>Biomedical Engineering Society 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-35b9fdcb36580c2357be16fcbe970dab174d2f7421f8dc9741eb4af2b0ceea9b3</citedby><cites>FETCH-LOGICAL-c536t-35b9fdcb36580c2357be16fcbe970dab174d2f7421f8dc9741eb4af2b0ceea9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999255/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999255/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27570565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Irianto, Jerome</creatorcontrib><creatorcontrib>Pfeifer, Charlotte R.</creatorcontrib><creatorcontrib>Ivanovska, Irena L.</creatorcontrib><creatorcontrib>Swift, Joe</creatorcontrib><creatorcontrib>Discher, Dennis E.</creatorcontrib><title>Nuclear Lamins in Cancer</title><title>Cellular and molecular bioengineering</title><addtitle>Cel. Mol. Bioeng</addtitle><addtitle>Cell Mol Bioeng</addtitle><description>Dysmorphic nuclei are commonly seen in cancers and provide strong motivation for studying in various cancer contexts the main structural proteins of nuclei, the lamins. Past studies have separately demonstrated the importance of microenvironment mechanics to cancer progression, which is extremely interesting because the lamina was recently shown to be mechanosensitive. Here, we review current knowledge relating cancer progression to lamina biophysics and biology. Lamin levels can modulate cancer cell migration in 3D and thereby impact tumor growth, and lamins can also protect or not a cancer cell’s genome. In addition, lamins can influence transcriptional regulators (RAR, SRF, YAP/TAZ) as well as chromosome conformation in lamina associated domains. Further investigation of the roles for lamins in cancer and even DNA damage may lead to new therapies or at least to a clearer understanding of lamins as bio-markers in cancer progression.</description><subject>Bioengineering</subject><subject>Biological and Medical Physics</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biophysics</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cellular</subject><subject>DNA damage</subject><subject>Engineering</subject><subject>Genomes</subject><subject>Homeostasis</subject><subject>Laminates</subject><subject>Nuclei</subject><subject>Progressions</subject><subject>Signal transduction</subject><subject>Therapy</subject><subject>Three dimensional</subject><subject>Transcription 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| subjects | Bioengineering Biological and Medical Physics Biomaterials Biomedical Engineering and Bioengineering Biomedical Engineering/Biotechnology Biophysics Cancer Cell Biology Cellular DNA damage Engineering Genomes Homeostasis Laminates Nuclei Progressions Signal transduction Therapy Three dimensional Transcription factors |
| title | Nuclear Lamins in Cancer |
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