Recent advances of cocktail chemotherapy by combination drug delivery systems
Combination chemotherapy is widely exploited for enhanced cancer treatment in the clinic. However, the traditional cocktail administration of combination regimens often suffers from varying pharmacokinetics among different drugs. The emergence of nanotechnology offers an unparalleled opportunity for...
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| Veröffentlicht in: | Advanced drug delivery reviews 2016-03, Vol.98, p.19-34 |
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| creator | Hu, Quanyin Sun, Wujin Wang, Chao Gu, Zhen |
| description | Combination chemotherapy is widely exploited for enhanced cancer treatment in the clinic. However, the traditional cocktail administration of combination regimens often suffers from varying pharmacokinetics among different drugs. The emergence of nanotechnology offers an unparalleled opportunity for developing advanced combination drug delivery strategies with the ability to encapsulate various drugs simultaneously and unify the pharmacokinetics of each drug. This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers. The mechanisms underlying combination chemotherapy, including the synergistic, additive and potentiation effects, are also discussed with typical examples. We further highlight the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems. Clinical outlook and challenges are also discussed in the end.
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| doi_str_mv | 10.1016/j.addr.2015.10.022 |
| format | Article |
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[Display omitted]</description><subject>Animals</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Combination</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Humans</subject><subject>Nanocarriers</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - therapeutic use</subject><subject>Neoplasms - drug therapy</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVoyW7-fIEcio-9eCvJsiVBKJTQJoENhZBAbkKWxlltbGsreQ3-9pHZNLSXnARv3jzNzA-hC4JXBJPq23alrQ0rikmZhBWm9AgtieA0F1SyT2iZTDJnWD4t0EmMW4wJ5RU-RgtalaziJVmiu3sw0A-ZtqPuDcTMN5nx5mXQrs3MBjo_bCDo3ZTVUyp0tev14Hyf2bB_ziy0boQwZXGKA3TxDH1udBvh_O09RY-_fj5c3eTr39e3Vz_WuWFCDDkDXYnGGCCNZY2luih5jYkmktmSCq6x5cC4bEhTlJjVjBVY2DQ6YQVLWnGKvh9yd_u6AztvEHSrdsF1OkzKa6f-r_Ruo579qJiUQrAyBXx9Cwj-zx7ioDoXDbSt7sHvoyJcYskZ4ThZ6cFqgo8xQPP-DcFq5qC2auagZg6zljikpi__Dvje8vfwyXB5MEA60-ggqGgcJALWBTCDst59lP8KJXubKg</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Hu, Quanyin</creator><creator>Sun, Wujin</creator><creator>Wang, Chao</creator><creator>Gu, Zhen</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>Recent advances of cocktail chemotherapy by combination drug delivery systems</title><author>Hu, Quanyin ; Sun, Wujin ; Wang, Chao ; Gu, Zhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-4ea68fcce1fd4fd2a357b01a194d5287a0d7e479f1f3504b44308d76014341f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Combination</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>Humans</topic><topic>Nanocarriers</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - therapeutic use</topic><topic>Neoplasms - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Quanyin</creatorcontrib><creatorcontrib>Sun, Wujin</creatorcontrib><creatorcontrib>Wang, Chao</creatorcontrib><creatorcontrib>Gu, Zhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Quanyin</au><au>Sun, Wujin</au><au>Wang, Chao</au><au>Gu, Zhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent advances of cocktail chemotherapy by combination drug delivery systems</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>98</volume><spage>19</spage><epage>34</epage><pages>19-34</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>Combination chemotherapy is widely exploited for enhanced cancer treatment in the clinic. 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| fulltext | fulltext |
| identifier | ISSN: 0169-409X |
| ispartof | Advanced drug delivery reviews, 2016-03, Vol.98, p.19-34 |
| issn | 0169-409X 1872-8294 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Chemotherapy Combination Drug delivery Drug Delivery Systems Humans Nanocarriers Nanoparticles - administration & dosage Nanoparticles - therapeutic use Neoplasms - drug therapy |
| title | Recent advances of cocktail chemotherapy by combination drug delivery systems |
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