Dodecafluoropentane Emulsion Extends Window for tPA Therapy in a Rabbit Stroke Model

Dodecafluoropentane emulsion (DDFPe) nanodroplets are exceptional oxygen transporters and can protect ischemic brain in stroke models 24 h without reperfusion. Current stroke therapy usually fails to reach patients because of delays following stroke onset. We tested using DDFPe to extend the time wi...

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Veröffentlicht in:	Molecular neurobiology 2015-10, Vol.52 (2), p.979-984
Hauptverfasser:	Culp, W. C., Brown, A. T., Lowery, J. D., Arthur, M. C., Roberson, P. K., Skinner, R. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cell Biology Cerebral Hemorrhage - chemically induced Disease Models, Animal Drug Administration Schedule Drug Evaluation, Preclinical Emulsions Female Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - therapeutic use Fibrinolytic Agents - toxicity Fluorocarbons - administration & dosage Fluorocarbons - therapeutic use Infarction, Anterior Cerebral Artery - drug therapy Infarction, Anterior Cerebral Artery - pathology Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - pathology Infusions, Intravenous Male Neurobiology Neurology Neuroprotective Agents - administration & dosage Neuroprotective Agents - therapeutic use Neurosciences Pharmacology Rabbits Random Allocation Reperfusion Injury - prevention & control Single-Blind Method Stroke Thrombolytic Therapy - adverse effects Thrombolytic Therapy - methods Time Factors Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - therapeutic use Tissue Plasminogen Activator - toxicity
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