Shearwave Elastography Increases Diagnostic Accuracy in Characterization of Breast Lesions
The purpose of this study was to investigate the diagnostic efficacy of shearwave elastography (SWE) in differentiating between benign and malignant breast lesions.One hundred and fifty-nine lesions were assessed using B-mode ultrasound (US) and SWE parameters were recorded (Emax, Emean, Emin, Erati...
Gespeichert in:
| Veröffentlicht in: | Medicine (Baltimore) 2016-03, Vol.95 (12), p.e3146-e3146 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e3146 |
|---|---|
| container_issue | 12 |
| container_start_page | e3146 |
| container_title | Medicine (Baltimore) |
| container_volume | 95 |
| creator | Ng, Wei Lin Rahmat, Kartini Fadzli, Farhana Rozalli, Faizatul Izza Mohd-Shah, Mohammad Nazri Chandran, Patricia Ann Westerhout, Caroline Judy Vijayananthan, Anushya Abdul Aziz, Yang Faridah |
| description | The purpose of this study was to investigate the diagnostic efficacy of shearwave elastography (SWE) in differentiating between benign and malignant breast lesions.One hundred and fifty-nine lesions were assessed using B-mode ultrasound (US) and SWE parameters were recorded (Emax, Emean, Emin, Eratio, SD). SWE measurements were then correlated with histopathological diagnosis.The final sample contained 85 benign and 74 malignant lesions. The maximum stiffness (Emax) with a cutoff point of ≥ 56.0 kPa (based on ROC curves) provided sensitivity of 100.0%, specificity of 97.6%, positive predictive value (PPV) of 97.4%, and negative predictive value (NPV) of 100% in detecting malignant lesions. A cutoff of ≥80 kPa managed to downgrade 95.5% of the Breast Imaging-Reporting and Data System (BI-RADS) 4a lesions to BI-RADS 3, negating the need for biopsy. Using a combination of BI-RADS and SWE, the authors managed to improve the PPV from 2.3% to 50% in BI-RADS 4a lesions.SWE of the breast provides highly specific and sensitive quantitative values that are beneficial in the characterization of breast lesions. Our results showed that Emax is the most accurate value for differentiating benign from malignant lesions. |
| doi_str_mv | 10.1097/MD.0000000000003146 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4998391</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1776090230</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4503-b94fb214d7e020cbc8f328bab18bd44dc04833922c5beb13624d92544d1ac8e53</originalsourceid><addsrcrecordid>eNpdkU9vEzEQxS0EoqHwCZCQj1y2jP-t1xekkhSolIoDcOFi2V5v1rBZB3u3Ufj0OKRUhbl45HnvN5YfQi8JXBBQ8s3N6gIeFCO8foQWRLC6Eqrmj9ECgIpKKsnP0LOcvwMQJil_is6oBCKIqhfo2-fem7Q3tx5fDSZPcZPMrj_g69Elb7LPeBXMZox5Cg5fOjcn4w44jHjZm9JOPoVfZgpxxLHD746WCa99Lhf5OXrSmSH7F3fnOfr6_urL8mO1_vThenm5rhwXwCqreGcp4a30QMFZ13SMNtZY0tiW89YBbxhTlDphvSWsprxVVJQJMa7xgp2jtyfubrZb3zo_TskMepfC1qSDjibofydj6PUm3mquVMMUKYDXd4AUf84-T3obsvPDYEYf56yJlDUooAyKlJ2kLsWck-_u1xDQx1T0zUr_n0pxvXr4wnvP3xiKgJ8E-ziUL80_hnnvky7RDFP_hyekohUFUgOjFKojmbHfS_qZFQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1776090230</pqid></control><display><type>article</type><title>Shearwave Elastography Increases Diagnostic Accuracy in Characterization of Breast Lesions</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>IngentaConnect Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><source>Wolters Kluwer Open Access</source><creator>Ng, Wei Lin ; Rahmat, Kartini ; Fadzli, Farhana ; Rozalli, Faizatul Izza ; Mohd-Shah, Mohammad Nazri ; Chandran, Patricia Ann ; Westerhout, Caroline Judy ; Vijayananthan, Anushya ; Abdul Aziz, Yang Faridah</creator><creatorcontrib>Ng, Wei Lin ; Rahmat, Kartini ; Fadzli, Farhana ; Rozalli, Faizatul Izza ; Mohd-Shah, Mohammad Nazri ; Chandran, Patricia Ann ; Westerhout, Caroline Judy ; Vijayananthan, Anushya ; Abdul Aziz, Yang Faridah</creatorcontrib><description>The purpose of this study was to investigate the diagnostic efficacy of shearwave elastography (SWE) in differentiating between benign and malignant breast lesions.One hundred and fifty-nine lesions were assessed using B-mode ultrasound (US) and SWE parameters were recorded (Emax, Emean, Emin, Eratio, SD). SWE measurements were then correlated with histopathological diagnosis.The final sample contained 85 benign and 74 malignant lesions. The maximum stiffness (Emax) with a cutoff point of ≥ 56.0 kPa (based on ROC curves) provided sensitivity of 100.0%, specificity of 97.6%, positive predictive value (PPV) of 97.4%, and negative predictive value (NPV) of 100% in detecting malignant lesions. A cutoff of ≥80 kPa managed to downgrade 95.5% of the Breast Imaging-Reporting and Data System (BI-RADS) 4a lesions to BI-RADS 3, negating the need for biopsy. Using a combination of BI-RADS and SWE, the authors managed to improve the PPV from 2.3% to 50% in BI-RADS 4a lesions.SWE of the breast provides highly specific and sensitive quantitative values that are beneficial in the characterization of breast lesions. Our results showed that Emax is the most accurate value for differentiating benign from malignant lesions.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000003146</identifier><identifier>PMID: 27015196</identifier><language>eng</language><publisher>United States: Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy ; Breast Density ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - pathology ; Child ; Diagnostic Accuracy Study ; Elasticity Imaging Techniques - methods ; Female ; Humans ; Mammary Glands, Human - abnormalities ; Middle Aged ; Sensitivity and Specificity ; Ultrasonography, Mammary - methods ; Young Adult</subject><ispartof>Medicine (Baltimore), 2016-03, Vol.95 (12), p.e3146-e3146</ispartof><rights>Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4503-b94fb214d7e020cbc8f328bab18bd44dc04833922c5beb13624d92544d1ac8e53</citedby><cites>FETCH-LOGICAL-c4503-b94fb214d7e020cbc8f328bab18bd44dc04833922c5beb13624d92544d1ac8e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998391/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998391/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27015196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, Wei Lin</creatorcontrib><creatorcontrib>Rahmat, Kartini</creatorcontrib><creatorcontrib>Fadzli, Farhana</creatorcontrib><creatorcontrib>Rozalli, Faizatul Izza</creatorcontrib><creatorcontrib>Mohd-Shah, Mohammad Nazri</creatorcontrib><creatorcontrib>Chandran, Patricia Ann</creatorcontrib><creatorcontrib>Westerhout, Caroline Judy</creatorcontrib><creatorcontrib>Vijayananthan, Anushya</creatorcontrib><creatorcontrib>Abdul Aziz, Yang Faridah</creatorcontrib><title>Shearwave Elastography Increases Diagnostic Accuracy in Characterization of Breast Lesions</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The purpose of this study was to investigate the diagnostic efficacy of shearwave elastography (SWE) in differentiating between benign and malignant breast lesions.One hundred and fifty-nine lesions were assessed using B-mode ultrasound (US) and SWE parameters were recorded (Emax, Emean, Emin, Eratio, SD). SWE measurements were then correlated with histopathological diagnosis.The final sample contained 85 benign and 74 malignant lesions. The maximum stiffness (Emax) with a cutoff point of ≥ 56.0 kPa (based on ROC curves) provided sensitivity of 100.0%, specificity of 97.6%, positive predictive value (PPV) of 97.4%, and negative predictive value (NPV) of 100% in detecting malignant lesions. A cutoff of ≥80 kPa managed to downgrade 95.5% of the Breast Imaging-Reporting and Data System (BI-RADS) 4a lesions to BI-RADS 3, negating the need for biopsy. Using a combination of BI-RADS and SWE, the authors managed to improve the PPV from 2.3% to 50% in BI-RADS 4a lesions.SWE of the breast provides highly specific and sensitive quantitative values that are beneficial in the characterization of breast lesions. Our results showed that Emax is the most accurate value for differentiating benign from malignant lesions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy</subject><subject>Breast Density</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - pathology</subject><subject>Child</subject><subject>Diagnostic Accuracy Study</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Mammary Glands, Human - abnormalities</subject><subject>Middle Aged</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonography, Mammary - methods</subject><subject>Young Adult</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9vEzEQxS0EoqHwCZCQj1y2jP-t1xekkhSolIoDcOFi2V5v1rBZB3u3Ufj0OKRUhbl45HnvN5YfQi8JXBBQ8s3N6gIeFCO8foQWRLC6Eqrmj9ECgIpKKsnP0LOcvwMQJil_is6oBCKIqhfo2-fem7Q3tx5fDSZPcZPMrj_g69Elb7LPeBXMZox5Cg5fOjcn4w44jHjZm9JOPoVfZgpxxLHD746WCa99Lhf5OXrSmSH7F3fnOfr6_urL8mO1_vThenm5rhwXwCqreGcp4a30QMFZ13SMNtZY0tiW89YBbxhTlDphvSWsprxVVJQJMa7xgp2jtyfubrZb3zo_TskMepfC1qSDjibofydj6PUm3mquVMMUKYDXd4AUf84-T3obsvPDYEYf56yJlDUooAyKlJ2kLsWck-_u1xDQx1T0zUr_n0pxvXr4wnvP3xiKgJ8E-ziUL80_hnnvky7RDFP_hyekohUFUgOjFKojmbHfS_qZFQ</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Ng, Wei Lin</creator><creator>Rahmat, Kartini</creator><creator>Fadzli, Farhana</creator><creator>Rozalli, Faizatul Izza</creator><creator>Mohd-Shah, Mohammad Nazri</creator><creator>Chandran, Patricia Ann</creator><creator>Westerhout, Caroline Judy</creator><creator>Vijayananthan, Anushya</creator><creator>Abdul Aziz, Yang Faridah</creator><general>Wolters Kluwer Health, Inc. All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160301</creationdate><title>Shearwave Elastography Increases Diagnostic Accuracy in Characterization of Breast Lesions</title><author>Ng, Wei Lin ; Rahmat, Kartini ; Fadzli, Farhana ; Rozalli, Faizatul Izza ; Mohd-Shah, Mohammad Nazri ; Chandran, Patricia Ann ; Westerhout, Caroline Judy ; Vijayananthan, Anushya ; Abdul Aziz, Yang Faridah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4503-b94fb214d7e020cbc8f328bab18bd44dc04833922c5beb13624d92544d1ac8e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy</topic><topic>Breast Density</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - pathology</topic><topic>Child</topic><topic>Diagnostic Accuracy Study</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Mammary Glands, Human - abnormalities</topic><topic>Middle Aged</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonography, Mammary - methods</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, Wei Lin</creatorcontrib><creatorcontrib>Rahmat, Kartini</creatorcontrib><creatorcontrib>Fadzli, Farhana</creatorcontrib><creatorcontrib>Rozalli, Faizatul Izza</creatorcontrib><creatorcontrib>Mohd-Shah, Mohammad Nazri</creatorcontrib><creatorcontrib>Chandran, Patricia Ann</creatorcontrib><creatorcontrib>Westerhout, Caroline Judy</creatorcontrib><creatorcontrib>Vijayananthan, Anushya</creatorcontrib><creatorcontrib>Abdul Aziz, Yang Faridah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, Wei Lin</au><au>Rahmat, Kartini</au><au>Fadzli, Farhana</au><au>Rozalli, Faizatul Izza</au><au>Mohd-Shah, Mohammad Nazri</au><au>Chandran, Patricia Ann</au><au>Westerhout, Caroline Judy</au><au>Vijayananthan, Anushya</au><au>Abdul Aziz, Yang Faridah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shearwave Elastography Increases Diagnostic Accuracy in Characterization of Breast Lesions</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>95</volume><issue>12</issue><spage>e3146</spage><epage>e3146</epage><pages>e3146-e3146</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The purpose of this study was to investigate the diagnostic efficacy of shearwave elastography (SWE) in differentiating between benign and malignant breast lesions.One hundred and fifty-nine lesions were assessed using B-mode ultrasound (US) and SWE parameters were recorded (Emax, Emean, Emin, Eratio, SD). SWE measurements were then correlated with histopathological diagnosis.The final sample contained 85 benign and 74 malignant lesions. The maximum stiffness (Emax) with a cutoff point of ≥ 56.0 kPa (based on ROC curves) provided sensitivity of 100.0%, specificity of 97.6%, positive predictive value (PPV) of 97.4%, and negative predictive value (NPV) of 100% in detecting malignant lesions. A cutoff of ≥80 kPa managed to downgrade 95.5% of the Breast Imaging-Reporting and Data System (BI-RADS) 4a lesions to BI-RADS 3, negating the need for biopsy. Using a combination of BI-RADS and SWE, the authors managed to improve the PPV from 2.3% to 50% in BI-RADS 4a lesions.SWE of the breast provides highly specific and sensitive quantitative values that are beneficial in the characterization of breast lesions. Our results showed that Emax is the most accurate value for differentiating benign from malignant lesions.</abstract><cop>United States</cop><pub>Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>27015196</pmid><doi>10.1097/MD.0000000000003146</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0025-7974 |
| ispartof | Medicine (Baltimore), 2016-03, Vol.95 (12), p.e3146-e3146 |
| issn | 0025-7974 1536-5964 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4998391 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Open Access; PubMed Central; Alma/SFX Local Collection; EZB Electronic Journals Library; Wolters Kluwer Open Access |
| subjects | Adolescent Adult Aged Aged, 80 and over Biopsy Breast Density Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Child Diagnostic Accuracy Study Elasticity Imaging Techniques - methods Female Humans Mammary Glands, Human - abnormalities Middle Aged Sensitivity and Specificity Ultrasonography, Mammary - methods Young Adult |
| title | Shearwave Elastography Increases Diagnostic Accuracy in Characterization of Breast Lesions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T21%3A43%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Shearwave%20Elastography%20Increases%20Diagnostic%20Accuracy%20in%20Characterization%20of%20Breast%20Lesions&rft.jtitle=Medicine%20(Baltimore)&rft.au=Ng,%20Wei%20Lin&rft.date=2016-03-01&rft.volume=95&rft.issue=12&rft.spage=e3146&rft.epage=e3146&rft.pages=e3146-e3146&rft.issn=0025-7974&rft.eissn=1536-5964&rft_id=info:doi/10.1097/MD.0000000000003146&rft_dat=%3Cproquest_pubme%3E1776090230%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1776090230&rft_id=info:pmid/27015196&rfr_iscdi=true |