Safety and efficacy of etomidate and propofol anesthesia in elderly patients undergoing gastroscopy: A double-blind randomized clinical study
The aim of the present study is to compare the safety, efficacy and cost effectiveness of anesthetic regimens by compound, using etomidate and propofol in elderly patients undergoing gastroscopy. A total of 200 volunteers (65-79 years of age) scheduled for gastroscopy under anesthesia were randomly...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2016-09, Vol.12 (3), p.1515-1524 |
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| creator | Meng, Qing-Tao Cao, Chen Liu, Hui-Min Xia, Zhong-Yuan Li, Wei Tang, Ling-Hua Chen, Rong Jiang, Meng Wu, Yang Leng, Yan Lee, Chris C |
| description | The aim of the present study is to compare the safety, efficacy and cost effectiveness of anesthetic regimens by compound, using etomidate and propofol in elderly patients undergoing gastroscopy. A total of 200 volunteers (65-79 years of age) scheduled for gastroscopy under anesthesia were randomly divided into the following groups: P, propofol (1.5-2.0 mg/kg); E, etomidate (0.15-0.2 mg/kg); P+E, propofol (0.75-1 mg/kg) followed by etomidate (0.075-0.1 mg/kg); and E+P, etomidate (0.075-0.01 mg/kg) followed by propofol (0.75-1 mg/kg). Vital signs and bispectral index were monitored at different time points. Complications, induction and examination time, anesthesia duration, and recovery and discharge time were recorded. At the end of the procedure, the satisfaction of patients, endoscopists and the anesthetist were evaluated. The recovery (6.1±1.2 h) and discharge times (24.8±2.8 h) in group E were significantly longer compared with groups P, P+E and E+P (P |
| doi_str_mv | 10.3892/etm.2016.3475 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4998221</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A463291948</galeid><sourcerecordid>A463291948</sourcerecordid><originalsourceid>FETCH-LOGICAL-c512t-646a38139699597f0826b0c41c1cae6e5ddf486d1cbe96ea4a93a448d644ab0d3</originalsourceid><addsrcrecordid>eNptkk2P1SAUhhujcSbjLN0aEmPipldoKQUXJjeT8SMZ48JxTSicdpjQUks7Sf0P_mfPnXu9OkZYAIfnvMDhzbLnjG5KqYo3MPebgjKxKXldPcpOWa2KnFFWPT7MqZLsJDtP6ZZiqwSTsnqanRS1oAWtq9Ps51fTwrwSMzgCbeutsSuJLYE59t6ZGe53ximOsY0BF5DmG0jeED8QCA6msJLRzB6GOZFlwEAX_dCRzqR5isnGcX1LtsTFpQmQN8Gj3ISaKP8DHLEYwEMDSfPi1mfZk9aEBOeH8Sz79v7y-uJjfvXlw6eL7VVuK1bMueDClJKVSihVqbqlshANtZxZZg0IqJxruRSO2QaUAMONKg3n0gnOTUNdeZa92-uOS9ODs3j5yQQ9Tr4306qj8frhzuBvdBfvNFdKFgVDgdcHgSl-X7AmuvfJQghYoLgkzSTeq5B1VSH68h_0Ni7TgM_TTJWMlkpx_ofqTADthzbiuXYnqrdclIViikukNv-hsDvovY0DtB7jDxLyfYLFv0gTtMc3Mqp3FtJoIb2zkN5ZCPkXfxfmSP82DAKv9kAa8RO9i-nIXF5_zin2e6Ff33LQBw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1931039944</pqid></control><display><type>article</type><title>Safety and efficacy of etomidate and propofol anesthesia in elderly patients undergoing gastroscopy: A double-blind randomized clinical study</title><source>PubMed Central</source><creator>Meng, Qing-Tao ; Cao, Chen ; Liu, Hui-Min ; Xia, Zhong-Yuan ; Li, Wei ; Tang, Ling-Hua ; Chen, Rong ; Jiang, Meng ; Wu, Yang ; Leng, Yan ; Lee, Chris C</creator><creatorcontrib>Meng, Qing-Tao ; Cao, Chen ; Liu, Hui-Min ; Xia, Zhong-Yuan ; Li, Wei ; Tang, Ling-Hua ; Chen, Rong ; Jiang, Meng ; Wu, Yang ; Leng, Yan ; Lee, Chris C</creatorcontrib><description>The aim of the present study is to compare the safety, efficacy and cost effectiveness of anesthetic regimens by compound, using etomidate and propofol in elderly patients undergoing gastroscopy. A total of 200 volunteers (65-79 years of age) scheduled for gastroscopy under anesthesia were randomly divided into the following groups: P, propofol (1.5-2.0 mg/kg); E, etomidate (0.15-0.2 mg/kg); P+E, propofol (0.75-1 mg/kg) followed by etomidate (0.075-0.1 mg/kg); and E+P, etomidate (0.075-0.01 mg/kg) followed by propofol (0.75-1 mg/kg). Vital signs and bispectral index were monitored at different time points. Complications, induction and examination time, anesthesia duration, and recovery and discharge time were recorded. At the end of the procedure, the satisfaction of patients, endoscopists and the anesthetist were evaluated. The recovery (6.1±1.2 h) and discharge times (24.8±2.8 h) in group E were significantly longer compared with groups P, P+E and E+P (P<0.05). The occurrence of injection pain in group P+E was significantly higher compared with the other three groups (P<0.05). In addition, the incidence of myoclonus and post-operative nausea and vomiting were significantly higher in group P+E compared with the other three groups (P<0.05). There was no statistical difference among the four groups with regards to the patients' immediate, post-procedure satisfaction (P>0.05). Furthermore, there was no difference in the satisfaction of anesthesia, as evaluated by the anesthetist and endoscopist, among the four groups (P>0.05). The present study demonstrates that anesthesia for gastroscopy in elderly patients can be safely and effectively accomplished using a drug regimen that combines propofol with etomidate. The combined use of propofol and etomidate has unique characteristics which improve hemodynamic stability, cause minimal respiratory depression and less side effects, provide rapid return to full activity and result in high levels of satisfaction.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2016.3475</identifier><identifier>PMID: 27602075</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Aged patients ; Analysis ; Anesthesia ; Dosage and administration ; Double-blind studies ; Drug dosages ; elderly patients ; Endoscopy ; Etomidate ; Gastroscopy ; Health aspects ; Hospitals ; Ischemia ; Patient satisfaction ; Pharmaceuticals ; Propofol ; Safety and security measures ; Sleep ; Treatment outcome</subject><ispartof>Experimental and therapeutic medicine, 2016-09, Vol.12 (3), p.1515-1524</ispartof><rights>Copyright © 2016, Spandidos Publications</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><rights>Copyright © 2016, Spandidos Publications 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-646a38139699597f0826b0c41c1cae6e5ddf486d1cbe96ea4a93a448d644ab0d3</citedby><cites>FETCH-LOGICAL-c512t-646a38139699597f0826b0c41c1cae6e5ddf486d1cbe96ea4a93a448d644ab0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998221/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998221/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27602075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meng, Qing-Tao</creatorcontrib><creatorcontrib>Cao, Chen</creatorcontrib><creatorcontrib>Liu, Hui-Min</creatorcontrib><creatorcontrib>Xia, Zhong-Yuan</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Tang, Ling-Hua</creatorcontrib><creatorcontrib>Chen, Rong</creatorcontrib><creatorcontrib>Jiang, Meng</creatorcontrib><creatorcontrib>Wu, Yang</creatorcontrib><creatorcontrib>Leng, Yan</creatorcontrib><creatorcontrib>Lee, Chris C</creatorcontrib><title>Safety and efficacy of etomidate and propofol anesthesia in elderly patients undergoing gastroscopy: A double-blind randomized clinical study</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>The aim of the present study is to compare the safety, efficacy and cost effectiveness of anesthetic regimens by compound, using etomidate and propofol in elderly patients undergoing gastroscopy. A total of 200 volunteers (65-79 years of age) scheduled for gastroscopy under anesthesia were randomly divided into the following groups: P, propofol (1.5-2.0 mg/kg); E, etomidate (0.15-0.2 mg/kg); P+E, propofol (0.75-1 mg/kg) followed by etomidate (0.075-0.1 mg/kg); and E+P, etomidate (0.075-0.01 mg/kg) followed by propofol (0.75-1 mg/kg). Vital signs and bispectral index were monitored at different time points. Complications, induction and examination time, anesthesia duration, and recovery and discharge time were recorded. At the end of the procedure, the satisfaction of patients, endoscopists and the anesthetist were evaluated. The recovery (6.1±1.2 h) and discharge times (24.8±2.8 h) in group E were significantly longer compared with groups P, P+E and E+P (P<0.05). The occurrence of injection pain in group P+E was significantly higher compared with the other three groups (P<0.05). In addition, the incidence of myoclonus and post-operative nausea and vomiting were significantly higher in group P+E compared with the other three groups (P<0.05). There was no statistical difference among the four groups with regards to the patients' immediate, post-procedure satisfaction (P>0.05). Furthermore, there was no difference in the satisfaction of anesthesia, as evaluated by the anesthetist and endoscopist, among the four groups (P>0.05). The present study demonstrates that anesthesia for gastroscopy in elderly patients can be safely and effectively accomplished using a drug regimen that combines propofol with etomidate. The combined use of propofol and etomidate has unique characteristics which improve hemodynamic stability, cause minimal respiratory depression and less side effects, provide rapid return to full activity and result in high levels of satisfaction.</description><subject>Aged patients</subject><subject>Analysis</subject><subject>Anesthesia</subject><subject>Dosage and administration</subject><subject>Double-blind studies</subject><subject>Drug dosages</subject><subject>elderly patients</subject><subject>Endoscopy</subject><subject>Etomidate</subject><subject>Gastroscopy</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Ischemia</subject><subject>Patient satisfaction</subject><subject>Pharmaceuticals</subject><subject>Propofol</subject><subject>Safety and security measures</subject><subject>Sleep</subject><subject>Treatment outcome</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk2P1SAUhhujcSbjLN0aEmPipldoKQUXJjeT8SMZ48JxTSicdpjQUks7Sf0P_mfPnXu9OkZYAIfnvMDhzbLnjG5KqYo3MPebgjKxKXldPcpOWa2KnFFWPT7MqZLsJDtP6ZZiqwSTsnqanRS1oAWtq9Ps51fTwrwSMzgCbeutsSuJLYE59t6ZGe53ximOsY0BF5DmG0jeED8QCA6msJLRzB6GOZFlwEAX_dCRzqR5isnGcX1LtsTFpQmQN8Gj3ISaKP8DHLEYwEMDSfPi1mfZk9aEBOeH8Sz79v7y-uJjfvXlw6eL7VVuK1bMueDClJKVSihVqbqlshANtZxZZg0IqJxruRSO2QaUAMONKg3n0gnOTUNdeZa92-uOS9ODs3j5yQQ9Tr4306qj8frhzuBvdBfvNFdKFgVDgdcHgSl-X7AmuvfJQghYoLgkzSTeq5B1VSH68h_0Ni7TgM_TTJWMlkpx_ofqTADthzbiuXYnqrdclIViikukNv-hsDvovY0DtB7jDxLyfYLFv0gTtMc3Mqp3FtJoIb2zkN5ZCPkXfxfmSP82DAKv9kAa8RO9i-nIXF5_zin2e6Ff33LQBw</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>Meng, Qing-Tao</creator><creator>Cao, Chen</creator><creator>Liu, Hui-Min</creator><creator>Xia, Zhong-Yuan</creator><creator>Li, Wei</creator><creator>Tang, Ling-Hua</creator><creator>Chen, Rong</creator><creator>Jiang, Meng</creator><creator>Wu, Yang</creator><creator>Leng, Yan</creator><creator>Lee, Chris C</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160901</creationdate><title>Safety and efficacy of etomidate and propofol anesthesia in elderly patients undergoing gastroscopy: A double-blind randomized clinical study</title><author>Meng, Qing-Tao ; Cao, Chen ; Liu, Hui-Min ; Xia, Zhong-Yuan ; Li, Wei ; Tang, Ling-Hua ; Chen, Rong ; Jiang, Meng ; Wu, Yang ; Leng, Yan ; Lee, Chris C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-646a38139699597f0826b0c41c1cae6e5ddf486d1cbe96ea4a93a448d644ab0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged patients</topic><topic>Analysis</topic><topic>Anesthesia</topic><topic>Dosage and administration</topic><topic>Double-blind studies</topic><topic>Drug dosages</topic><topic>elderly patients</topic><topic>Endoscopy</topic><topic>Etomidate</topic><topic>Gastroscopy</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Ischemia</topic><topic>Patient satisfaction</topic><topic>Pharmaceuticals</topic><topic>Propofol</topic><topic>Safety and security measures</topic><topic>Sleep</topic><topic>Treatment outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meng, Qing-Tao</creatorcontrib><creatorcontrib>Cao, Chen</creatorcontrib><creatorcontrib>Liu, Hui-Min</creatorcontrib><creatorcontrib>Xia, Zhong-Yuan</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Tang, Ling-Hua</creatorcontrib><creatorcontrib>Chen, Rong</creatorcontrib><creatorcontrib>Jiang, Meng</creatorcontrib><creatorcontrib>Wu, Yang</creatorcontrib><creatorcontrib>Leng, Yan</creatorcontrib><creatorcontrib>Lee, Chris C</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Qing-Tao</au><au>Cao, Chen</au><au>Liu, Hui-Min</au><au>Xia, Zhong-Yuan</au><au>Li, Wei</au><au>Tang, Ling-Hua</au><au>Chen, Rong</au><au>Jiang, Meng</au><au>Wu, Yang</au><au>Leng, Yan</au><au>Lee, Chris C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and efficacy of etomidate and propofol anesthesia in elderly patients undergoing gastroscopy: A double-blind randomized clinical study</atitle><jtitle>Experimental and therapeutic medicine</jtitle><addtitle>Exp Ther Med</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>12</volume><issue>3</issue><spage>1515</spage><epage>1524</epage><pages>1515-1524</pages><issn>1792-0981</issn><eissn>1792-1015</eissn><abstract>The aim of the present study is to compare the safety, efficacy and cost effectiveness of anesthetic regimens by compound, using etomidate and propofol in elderly patients undergoing gastroscopy. A total of 200 volunteers (65-79 years of age) scheduled for gastroscopy under anesthesia were randomly divided into the following groups: P, propofol (1.5-2.0 mg/kg); E, etomidate (0.15-0.2 mg/kg); P+E, propofol (0.75-1 mg/kg) followed by etomidate (0.075-0.1 mg/kg); and E+P, etomidate (0.075-0.01 mg/kg) followed by propofol (0.75-1 mg/kg). Vital signs and bispectral index were monitored at different time points. Complications, induction and examination time, anesthesia duration, and recovery and discharge time were recorded. At the end of the procedure, the satisfaction of patients, endoscopists and the anesthetist were evaluated. The recovery (6.1±1.2 h) and discharge times (24.8±2.8 h) in group E were significantly longer compared with groups P, P+E and E+P (P<0.05). The occurrence of injection pain in group P+E was significantly higher compared with the other three groups (P<0.05). In addition, the incidence of myoclonus and post-operative nausea and vomiting were significantly higher in group P+E compared with the other three groups (P<0.05). There was no statistical difference among the four groups with regards to the patients' immediate, post-procedure satisfaction (P>0.05). Furthermore, there was no difference in the satisfaction of anesthesia, as evaluated by the anesthetist and endoscopist, among the four groups (P>0.05). The present study demonstrates that anesthesia for gastroscopy in elderly patients can be safely and effectively accomplished using a drug regimen that combines propofol with etomidate. The combined use of propofol and etomidate has unique characteristics which improve hemodynamic stability, cause minimal respiratory depression and less side effects, provide rapid return to full activity and result in high levels of satisfaction.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>27602075</pmid><doi>10.3892/etm.2016.3475</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | PubMed Central |
| subjects | Aged patients Analysis Anesthesia Dosage and administration Double-blind studies Drug dosages elderly patients Endoscopy Etomidate Gastroscopy Health aspects Hospitals Ischemia Patient satisfaction Pharmaceuticals Propofol Safety and security measures Sleep Treatment outcome |
| title | Safety and efficacy of etomidate and propofol anesthesia in elderly patients undergoing gastroscopy: A double-blind randomized clinical study |
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