Conisation as a marker of persistent human papilloma virus infection and risk of breast cancer
Background: Human papillomavirus (HPV) infection may increase breast cancer (BC) risk. Methods: To examine this, we used nationwide medical registries to identify all Danish women who underwent conisation to remove HPV-associated cervical precancerous lesions ( n =87 782) from 1978 to 2013. We compu...
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| Veröffentlicht in: | British journal of cancer 2016-08, Vol.115 (5), p.588-591 |
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| creator | Søgaard, Mette Farkas, Dora K Ording, Anne G Sørensen, Henrik T P Cronin-Fenton, Deirdre |
| description | Background:
Human papillomavirus (HPV) infection may increase breast cancer (BC) risk.
Methods:
To examine this, we used nationwide medical registries to identify all Danish women who underwent conisation to remove HPV-associated cervical precancerous lesions (
n
=87 782) from 1978 to 2013. We computed the absolute risk of BC and standardised incidence ratios (SIRs) and 95% confidence intervals (95% CIs) for breast cancer, based on national breast cancer incidence rates.
Results:
Conisation was associated with slightly increased BC incidence (SIR=1.1, 95% CI=1.0–1.1), and an absolute BC risk of 7.7% (95% CI=7.3–8.1%) in 35.9 years of follow-up. BC risk was elevated throughout follow-up, especially in the first 5 years ( |
| doi_str_mv | 10.1038/bjc.2016.150 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4997534</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1819143291</sourcerecordid><originalsourceid>FETCH-LOGICAL-c483t-216f1311ce4604137baaa39506f26de87f3c2f501fa003b5170ffc0044b483ef3</originalsourceid><addsrcrecordid>eNqNkc1r3DAQxUVpaLZpbz0XQS851JsZybbsSyAs6QcEemmuEbJWSrSxJUeyA_nvK7NJSEsPOQkxv_c0T4-QTwhrBN6cdDu9ZoD1Git4Q1ZYcVZgw8RbsgIAUUDL4JC8T2mXry004h05ZIJVHAVfkatN8C6pyQVPVaKKDiremkiDpaOJyaXJ-InezIPydFSj6_swKHrv4pyo89bovdJvaXTpdpF10ag0Ua28NvEDObCqT-bj43lELr-d_978KC5-ff-5ObsodNnwqWBYW-SI2pQ1lMhFp5TibQW1ZfXWNMJyzWwFaBUA7yoUYK0GKMsu643lR-R07zvO3WC2Oi8dVS_H6HKeBxmUk39PvLuR1-Felm0rKl5mg-NHgxjuZpMmObikTd8rb8KcJDbYYslZi69Blwg1W1y__IPuwhx9_omF4hlpscnU1z2lY0gpGvu8N4JcOpa5Y7l0LHPHGf_8Musz_FRqBoo9kPLIX5v44tX_Gf4BwbOw4g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1813624918</pqid></control><display><type>article</type><title>Conisation as a marker of persistent human papilloma virus infection and risk of breast cancer</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Nature Journals Online</source><source>PubMed Central</source><creator>Søgaard, Mette ; Farkas, Dora K ; Ording, Anne G ; Sørensen, Henrik T ; P Cronin-Fenton, Deirdre</creator><creatorcontrib>Søgaard, Mette ; Farkas, Dora K ; Ording, Anne G ; Sørensen, Henrik T ; P Cronin-Fenton, Deirdre</creatorcontrib><description>Background:
Human papillomavirus (HPV) infection may increase breast cancer (BC) risk.
Methods:
To examine this, we used nationwide medical registries to identify all Danish women who underwent conisation to remove HPV-associated cervical precancerous lesions (
n
=87 782) from 1978 to 2013. We computed the absolute risk of BC and standardised incidence ratios (SIRs) and 95% confidence intervals (95% CIs) for breast cancer, based on national breast cancer incidence rates.
Results:
Conisation was associated with slightly increased BC incidence (SIR=1.1, 95% CI=1.0–1.1), and an absolute BC risk of 7.7% (95% CI=7.3–8.1%) in 35.9 years of follow-up. BC risk was elevated throughout follow-up, especially in the first 5 years (<1 year: SIR=1.2, 95% CI=0.92–1.5; 1–5 years: SIR=1.2, 95% CI=1.1–1.3; ⩾5 years: SIR=1.1, 95% CI=1.0–1.1). Women who underwent conisation and had autoimmune disease had elevated BC risk after 5 years of follow-up (SIR=1.4, 95% CI=1.0–1.8).
Conclusions:
BC risk is slightly elevated in women with persistent HPV infection, possibly due to detection bias.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2016.150</identifier><identifier>PMID: 27253173</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326/596/2560 ; 692/499 ; 692/699/255/2514 ; 692/699/67/1347 ; Adult ; Age ; Alcohol ; Autoimmune diseases ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - complications ; Cancer Research ; Comorbidity ; Conization ; Denmark ; Disease ; Drug Resistance ; Emigration ; Epidemiology ; Female ; Health services ; Human papillomavirus ; Humans ; Infections ; Medical research ; Molecular Medicine ; Obesity ; Oncology ; Papillomavirus Infections - complications ; Papillomavirus Infections - epidemiology ; Risk Factors ; Short Communication ; Tumors ; Uterine Cervical Neoplasms - complications ; Uterine Cervical Neoplasms - therapy ; Womens health</subject><ispartof>British journal of cancer, 2016-08, Vol.115 (5), p.588-591</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Aug 23, 2016</rights><rights>Copyright © 2016 Cancer Research UK 2016 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-216f1311ce4604137baaa39506f26de87f3c2f501fa003b5170ffc0044b483ef3</citedby><cites>FETCH-LOGICAL-c483t-216f1311ce4604137baaa39506f26de87f3c2f501fa003b5170ffc0044b483ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997534/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997534/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27253173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Søgaard, Mette</creatorcontrib><creatorcontrib>Farkas, Dora K</creatorcontrib><creatorcontrib>Ording, Anne G</creatorcontrib><creatorcontrib>Sørensen, Henrik T</creatorcontrib><creatorcontrib>P Cronin-Fenton, Deirdre</creatorcontrib><title>Conisation as a marker of persistent human papilloma virus infection and risk of breast cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Human papillomavirus (HPV) infection may increase breast cancer (BC) risk.
Methods:
To examine this, we used nationwide medical registries to identify all Danish women who underwent conisation to remove HPV-associated cervical precancerous lesions (
n
=87 782) from 1978 to 2013. We computed the absolute risk of BC and standardised incidence ratios (SIRs) and 95% confidence intervals (95% CIs) for breast cancer, based on national breast cancer incidence rates.
Results:
Conisation was associated with slightly increased BC incidence (SIR=1.1, 95% CI=1.0–1.1), and an absolute BC risk of 7.7% (95% CI=7.3–8.1%) in 35.9 years of follow-up. BC risk was elevated throughout follow-up, especially in the first 5 years (<1 year: SIR=1.2, 95% CI=0.92–1.5; 1–5 years: SIR=1.2, 95% CI=1.1–1.3; ⩾5 years: SIR=1.1, 95% CI=1.0–1.1). Women who underwent conisation and had autoimmune disease had elevated BC risk after 5 years of follow-up (SIR=1.4, 95% CI=1.0–1.8).
Conclusions:
BC risk is slightly elevated in women with persistent HPV infection, possibly due to detection bias.</description><subject>631/326/596/2560</subject><subject>692/499</subject><subject>692/699/255/2514</subject><subject>692/699/67/1347</subject><subject>Adult</subject><subject>Age</subject><subject>Alcohol</subject><subject>Autoimmune diseases</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - complications</subject><subject>Cancer Research</subject><subject>Comorbidity</subject><subject>Conization</subject><subject>Denmark</subject><subject>Disease</subject><subject>Drug Resistance</subject><subject>Emigration</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health services</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Infections</subject><subject>Medical research</subject><subject>Molecular Medicine</subject><subject>Obesity</subject><subject>Oncology</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Risk Factors</subject><subject>Short Communication</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - complications</subject><subject>Uterine Cervical Neoplasms - therapy</subject><subject>Womens health</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc1r3DAQxUVpaLZpbz0XQS851JsZybbsSyAs6QcEemmuEbJWSrSxJUeyA_nvK7NJSEsPOQkxv_c0T4-QTwhrBN6cdDu9ZoD1Git4Q1ZYcVZgw8RbsgIAUUDL4JC8T2mXry004h05ZIJVHAVfkatN8C6pyQVPVaKKDiremkiDpaOJyaXJ-InezIPydFSj6_swKHrv4pyo89bovdJvaXTpdpF10ag0Ua28NvEDObCqT-bj43lELr-d_978KC5-ff-5ObsodNnwqWBYW-SI2pQ1lMhFp5TibQW1ZfXWNMJyzWwFaBUA7yoUYK0GKMsu643lR-R07zvO3WC2Oi8dVS_H6HKeBxmUk39PvLuR1-Felm0rKl5mg-NHgxjuZpMmObikTd8rb8KcJDbYYslZi69Blwg1W1y__IPuwhx9_omF4hlpscnU1z2lY0gpGvu8N4JcOpa5Y7l0LHPHGf_8Musz_FRqBoo9kPLIX5v44tX_Gf4BwbOw4g</recordid><startdate>20160823</startdate><enddate>20160823</enddate><creator>Søgaard, Mette</creator><creator>Farkas, Dora K</creator><creator>Ording, Anne G</creator><creator>Sørensen, Henrik T</creator><creator>P Cronin-Fenton, Deirdre</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160823</creationdate><title>Conisation as a marker of persistent human papilloma virus infection and risk of breast cancer</title><author>Søgaard, Mette ; Farkas, Dora K ; Ording, Anne G ; Sørensen, Henrik T ; P Cronin-Fenton, Deirdre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-216f1311ce4604137baaa39506f26de87f3c2f501fa003b5170ffc0044b483ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/326/596/2560</topic><topic>692/499</topic><topic>692/699/255/2514</topic><topic>692/699/67/1347</topic><topic>Adult</topic><topic>Age</topic><topic>Alcohol</topic><topic>Autoimmune diseases</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - complications</topic><topic>Cancer Research</topic><topic>Comorbidity</topic><topic>Conization</topic><topic>Denmark</topic><topic>Disease</topic><topic>Drug Resistance</topic><topic>Emigration</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health services</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Infections</topic><topic>Medical research</topic><topic>Molecular Medicine</topic><topic>Obesity</topic><topic>Oncology</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Risk Factors</topic><topic>Short Communication</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - complications</topic><topic>Uterine Cervical Neoplasms - therapy</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Søgaard, Mette</creatorcontrib><creatorcontrib>Farkas, Dora K</creatorcontrib><creatorcontrib>Ording, Anne G</creatorcontrib><creatorcontrib>Sørensen, Henrik T</creatorcontrib><creatorcontrib>P Cronin-Fenton, Deirdre</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Søgaard, Mette</au><au>Farkas, Dora K</au><au>Ording, Anne G</au><au>Sørensen, Henrik T</au><au>P Cronin-Fenton, Deirdre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conisation as a marker of persistent human papilloma virus infection and risk of breast cancer</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2016-08-23</date><risdate>2016</risdate><volume>115</volume><issue>5</issue><spage>588</spage><epage>591</epage><pages>588-591</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Human papillomavirus (HPV) infection may increase breast cancer (BC) risk.
Methods:
To examine this, we used nationwide medical registries to identify all Danish women who underwent conisation to remove HPV-associated cervical precancerous lesions (
n
=87 782) from 1978 to 2013. We computed the absolute risk of BC and standardised incidence ratios (SIRs) and 95% confidence intervals (95% CIs) for breast cancer, based on national breast cancer incidence rates.
Results:
Conisation was associated with slightly increased BC incidence (SIR=1.1, 95% CI=1.0–1.1), and an absolute BC risk of 7.7% (95% CI=7.3–8.1%) in 35.9 years of follow-up. BC risk was elevated throughout follow-up, especially in the first 5 years (<1 year: SIR=1.2, 95% CI=0.92–1.5; 1–5 years: SIR=1.2, 95% CI=1.1–1.3; ⩾5 years: SIR=1.1, 95% CI=1.0–1.1). Women who underwent conisation and had autoimmune disease had elevated BC risk after 5 years of follow-up (SIR=1.4, 95% CI=1.0–1.8).
Conclusions:
BC risk is slightly elevated in women with persistent HPV infection, possibly due to detection bias.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27253173</pmid><doi>10.1038/bjc.2016.150</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/326/596/2560 692/499 692/699/255/2514 692/699/67/1347 Adult Age Alcohol Autoimmune diseases Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - complications Cancer Research Comorbidity Conization Denmark Disease Drug Resistance Emigration Epidemiology Female Health services Human papillomavirus Humans Infections Medical research Molecular Medicine Obesity Oncology Papillomavirus Infections - complications Papillomavirus Infections - epidemiology Risk Factors Short Communication Tumors Uterine Cervical Neoplasms - complications Uterine Cervical Neoplasms - therapy Womens health |
| title | Conisation as a marker of persistent human papilloma virus infection and risk of breast cancer |
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