PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population
Single-nucleotide polymorphisms (SNPs) in the protein phosphatase and actin regulator 1 gene (PHACTR1) have been associated with susceptibility to develop several diseases, including cardiovascular disease. The purpose of this study was to evaluate the role of two polymorphisms (rs2026458 and rs9349...
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| Veröffentlicht in: | International journal of environmental research and public health 2016-08, Vol.13 (8), p.1-1 |
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| creator | Pérez-Hernández, Nonanzit Vargas-Alarcón, Gilberto Posadas-Sánchez, Rosalinda Martínez-Rodríguez, Nancy Tovilla-Zárate, Carlos Alfonso Rodríguez-Cortés, Adrián Asael Pérez-Méndez, Oscar Blachman-Braun, Ruben Rodríguez-Pérez, José Manuel |
| description | Single-nucleotide polymorphisms (SNPs) in the protein phosphatase and actin regulator 1 gene (PHACTR1) have been associated with susceptibility to develop several diseases, including cardiovascular disease. The purpose of this study was to evaluate the role of two polymorphisms (rs2026458 and rs9349379) of the PHACTR1 gene in the susceptibility to the risk of developing premature coronary artery disease (CAD) in the Mexican population. The genotype analysis was performed using 5'exonuclease TaqMan genotyping assays in a group of 994 patients with premature CAD and 703 controls. A similar genotype distribution of rs2026458 was observed in both groups; however, under an additive model adjusted by age, body mass index, type 2 diabetes mellitus, smoking, dyslipidemia, and hypertension, the rs9349379 G allele was associated with a higher risk for developing premature CAD (odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.03-1.46, p-value (p) = 0.024). The two PHACTR1 polymorphisms were not in linkage disequilibrium. In summary, our results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population. |
| doi_str_mv | 10.3390/ijerph13080803 |
| format | Article |
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The purpose of this study was to evaluate the role of two polymorphisms (rs2026458 and rs9349379) of the PHACTR1 gene in the susceptibility to the risk of developing premature coronary artery disease (CAD) in the Mexican population. The genotype analysis was performed using 5'exonuclease TaqMan genotyping assays in a group of 994 patients with premature CAD and 703 controls. A similar genotype distribution of rs2026458 was observed in both groups; however, under an additive model adjusted by age, body mass index, type 2 diabetes mellitus, smoking, dyslipidemia, and hypertension, the rs9349379 G allele was associated with a higher risk for developing premature CAD (odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.03-1.46, p-value (p) = 0.024). The two PHACTR1 polymorphisms were not in linkage disequilibrium. In summary, our results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph13080803</identifier><identifier>PMID: 27517945</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adult ; Age ; Alcohol ; Alleles ; Atherosclerosis ; Calcification ; Cardiology ; Cardiovascular disease ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - genetics ; Coronary vessels ; Data collection ; Diabetes ; Dyslipidemias - genetics ; Family medical history ; Female ; Gene expression ; Genealogy ; Genetic Predisposition to Disease - genetics ; Genotype ; Haplotypes ; Heart attacks ; Humans ; Hypertension ; Hypertension - genetics ; Male ; Maximum likelihood method ; Metabolism ; Mexico ; Microfilament Proteins - genetics ; Middle Aged ; Minority & ethnic groups ; Odds Ratio ; Phosphatase ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Population ; Public health ; Risk factors ; Studies</subject><ispartof>International journal of environmental research and public health, 2016-08, Vol.13 (8), p.1-1</ispartof><rights>Copyright Molecular Diversity Preservation International Aug 2016</rights><rights>2016 by the authors; licensee MDPI, Basel, Switzerland. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-134e1e128d02c0f6806b185677aae50accbad6bad51883c12dfa16c7f2c5f303</citedby><cites>FETCH-LOGICAL-c451t-134e1e128d02c0f6806b185677aae50accbad6bad51883c12dfa16c7f2c5f303</cites><orcidid>0000-0002-3802-0897</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997489/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997489/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27517945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pérez-Hernández, Nonanzit</creatorcontrib><creatorcontrib>Vargas-Alarcón, Gilberto</creatorcontrib><creatorcontrib>Posadas-Sánchez, Rosalinda</creatorcontrib><creatorcontrib>Martínez-Rodríguez, Nancy</creatorcontrib><creatorcontrib>Tovilla-Zárate, Carlos Alfonso</creatorcontrib><creatorcontrib>Rodríguez-Cortés, Adrián Asael</creatorcontrib><creatorcontrib>Pérez-Méndez, Oscar</creatorcontrib><creatorcontrib>Blachman-Braun, Ruben</creatorcontrib><creatorcontrib>Rodríguez-Pérez, José Manuel</creatorcontrib><title>PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Single-nucleotide polymorphisms (SNPs) in the protein phosphatase and actin regulator 1 gene (PHACTR1) have been associated with susceptibility to develop several diseases, including cardiovascular disease. The purpose of this study was to evaluate the role of two polymorphisms (rs2026458 and rs9349379) of the PHACTR1 gene in the susceptibility to the risk of developing premature coronary artery disease (CAD) in the Mexican population. The genotype analysis was performed using 5'exonuclease TaqMan genotyping assays in a group of 994 patients with premature CAD and 703 controls. A similar genotype distribution of rs2026458 was observed in both groups; however, under an additive model adjusted by age, body mass index, type 2 diabetes mellitus, smoking, dyslipidemia, and hypertension, the rs9349379 G allele was associated with a higher risk for developing premature CAD (odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.03-1.46, p-value (p) = 0.024). The two PHACTR1 polymorphisms were not in linkage disequilibrium. In summary, our results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population.</description><subject>Adult</subject><subject>Age</subject><subject>Alcohol</subject><subject>Alleles</subject><subject>Atherosclerosis</subject><subject>Calcification</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary vessels</subject><subject>Data collection</subject><subject>Diabetes</subject><subject>Dyslipidemias - genetics</subject><subject>Family medical history</subject><subject>Female</subject><subject>Gene expression</subject><subject>Genealogy</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - genetics</subject><subject>Male</subject><subject>Maximum likelihood method</subject><subject>Metabolism</subject><subject>Mexico</subject><subject>Microfilament Proteins - genetics</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Odds Ratio</subject><subject>Phosphatase</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Population</subject><subject>Public health</subject><subject>Risk factors</subject><subject>Studies</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNksFu3CAQhlHVqknTXnuskHrpZVPGYIwvlVabNFkpVVbR3hGLx1m2Nrhgp8mxb15WSaOkpwiNhhHf_MzAEPIR2DHnNfvqdhiHLXCm8uKvyCFIyWZCMnj9ZH9A3qW0Y4wrIeu35KCoSqhqUR6SP6vz-WJ9BfQMPdJV6O76kAVd6uky0XlKwTozYkN_u3FLl95GNCmHVy79pKGlJ3iDXRicv6ariL0Zp4h0EWLwJt7ReRwxuxOX9lnUefoDb501Pt80TJ0ZXfDvyZvWdAk_PPgjsv5-ul6czy4uz5aL-cXMihLGGXCBgFCohhWWtVIxuQFVyqoyBktmrN2YRmYrQSluoWhaA9JWbWHLljN-RL7dyw7TpsfGoh-j6fQQXZ8r1cE4_fzEu62-Djda1HUlVJ0FvjwIxPBrwjTq3iWLXWc8hilpUFADlxxehBZCFAVTGf38H7oLU_T5IfaUYLk_UWbq-J6yMaQUsX2sG5jez4F-Pgc54dPTbh_xfx_P_wLogbC8</recordid><startdate>20160809</startdate><enddate>20160809</enddate><creator>Pérez-Hernández, Nonanzit</creator><creator>Vargas-Alarcón, Gilberto</creator><creator>Posadas-Sánchez, Rosalinda</creator><creator>Martínez-Rodríguez, Nancy</creator><creator>Tovilla-Zárate, Carlos Alfonso</creator><creator>Rodríguez-Cortés, Adrián Asael</creator><creator>Pérez-Méndez, Oscar</creator><creator>Blachman-Braun, Ruben</creator><creator>Rodríguez-Pérez, José Manuel</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7ST</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3802-0897</orcidid></search><sort><creationdate>20160809</creationdate><title>PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population</title><author>Pérez-Hernández, Nonanzit ; Vargas-Alarcón, Gilberto ; Posadas-Sánchez, Rosalinda ; Martínez-Rodríguez, Nancy ; Tovilla-Zárate, Carlos Alfonso ; Rodríguez-Cortés, Adrián Asael ; Pérez-Méndez, Oscar ; Blachman-Braun, Ruben ; Rodríguez-Pérez, José Manuel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-134e1e128d02c0f6806b185677aae50accbad6bad51883c12dfa16c7f2c5f303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age</topic><topic>Alcohol</topic><topic>Alleles</topic><topic>Atherosclerosis</topic><topic>Calcification</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary vessels</topic><topic>Data collection</topic><topic>Diabetes</topic><topic>Dyslipidemias - genetics</topic><topic>Family medical history</topic><topic>Female</topic><topic>Gene expression</topic><topic>Genealogy</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - genetics</topic><topic>Male</topic><topic>Maximum likelihood method</topic><topic>Metabolism</topic><topic>Mexico</topic><topic>Microfilament Proteins - genetics</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Odds Ratio</topic><topic>Phosphatase</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Population</topic><topic>Public health</topic><topic>Risk factors</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pérez-Hernández, Nonanzit</creatorcontrib><creatorcontrib>Vargas-Alarcón, Gilberto</creatorcontrib><creatorcontrib>Posadas-Sánchez, Rosalinda</creatorcontrib><creatorcontrib>Martínez-Rodríguez, Nancy</creatorcontrib><creatorcontrib>Tovilla-Zárate, Carlos Alfonso</creatorcontrib><creatorcontrib>Rodríguez-Cortés, Adrián Asael</creatorcontrib><creatorcontrib>Pérez-Méndez, Oscar</creatorcontrib><creatorcontrib>Blachman-Braun, Ruben</creatorcontrib><creatorcontrib>Rodríguez-Pérez, José Manuel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez-Hernández, Nonanzit</au><au>Vargas-Alarcón, Gilberto</au><au>Posadas-Sánchez, Rosalinda</au><au>Martínez-Rodríguez, Nancy</au><au>Tovilla-Zárate, Carlos Alfonso</au><au>Rodríguez-Cortés, Adrián Asael</au><au>Pérez-Méndez, Oscar</au><au>Blachman-Braun, Ruben</au><au>Rodríguez-Pérez, José Manuel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2016-08-09</date><risdate>2016</risdate><volume>13</volume><issue>8</issue><spage>1</spage><epage>1</epage><pages>1-1</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Single-nucleotide polymorphisms (SNPs) in the protein phosphatase and actin regulator 1 gene (PHACTR1) have been associated with susceptibility to develop several diseases, including cardiovascular disease. The purpose of this study was to evaluate the role of two polymorphisms (rs2026458 and rs9349379) of the PHACTR1 gene in the susceptibility to the risk of developing premature coronary artery disease (CAD) in the Mexican population. The genotype analysis was performed using 5'exonuclease TaqMan genotyping assays in a group of 994 patients with premature CAD and 703 controls. A similar genotype distribution of rs2026458 was observed in both groups; however, under an additive model adjusted by age, body mass index, type 2 diabetes mellitus, smoking, dyslipidemia, and hypertension, the rs9349379 G allele was associated with a higher risk for developing premature CAD (odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.03-1.46, p-value (p) = 0.024). The two PHACTR1 polymorphisms were not in linkage disequilibrium. In summary, our results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>27517945</pmid><doi>10.3390/ijerph13080803</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-3802-0897</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Adult Age Alcohol Alleles Atherosclerosis Calcification Cardiology Cardiovascular disease Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Coronary vessels Data collection Diabetes Dyslipidemias - genetics Family medical history Female Gene expression Genealogy Genetic Predisposition to Disease - genetics Genotype Haplotypes Heart attacks Humans Hypertension Hypertension - genetics Male Maximum likelihood method Metabolism Mexico Microfilament Proteins - genetics Middle Aged Minority & ethnic groups Odds Ratio Phosphatase Polymorphism Polymorphism, Single Nucleotide - genetics Population Public health Risk factors Studies |
| title | PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population |
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