Bioactive Compounds and Their Neuroprotective Effects in Diabetic Complications
Hyperglycemia, hyperlipidemia and impaired insulin signaling during the development of diabetes can cause diabetic complications, such as diabetic neuropathy, resulting in significant morbidity and mortality. Although various therapeutics are available for the treatment of diabetic neuropathy, no ab...
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| Veröffentlicht in: | Nutrients 2016-07, Vol.8 (8), p.472 |
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| description | Hyperglycemia, hyperlipidemia and impaired insulin signaling during the development of diabetes can cause diabetic complications, such as diabetic neuropathy, resulting in significant morbidity and mortality. Although various therapeutics are available for the treatment of diabetic neuropathy, no absolute cure exists, and additional research is necessary to comprehensively understand the underlying pathophysiological pathways. A number of studies have demonstrated the potential health benefits of bioactive compounds, i.e., flavonoids and vitamins, which may be effective as supplementary treatments for diabetes and its complications. In this review, we highlight the most recent reports about the mechanisms of action of bioactive compounds (flavonoids and vitamins) possessing potential neuroprotective properties in diabetic conditions. Additional clinical studies are required to determine the appropriate dose and duration of bioactive compound supplementation for neuroprotection in diabetic patients. |
| doi_str_mv | 10.3390/nu8080472 |
| format | Article |
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Although various therapeutics are available for the treatment of diabetic neuropathy, no absolute cure exists, and additional research is necessary to comprehensively understand the underlying pathophysiological pathways. A number of studies have demonstrated the potential health benefits of bioactive compounds, i.e., flavonoids and vitamins, which may be effective as supplementary treatments for diabetes and its complications. In this review, we highlight the most recent reports about the mechanisms of action of bioactive compounds (flavonoids and vitamins) possessing potential neuroprotective properties in diabetic conditions. Additional clinical studies are required to determine the appropriate dose and duration of bioactive compound supplementation for neuroprotection in diabetic patients.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu8080472</identifier><identifier>PMID: 27483315</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; bioactive compounds ; clinical trials ; Diabetic Neuropathies - metabolism ; Diabetic Neuropathies - prevention & control ; diabetic neuropathy ; Dietary Supplements - adverse effects ; flavonoids ; Flavonoids - adverse effects ; Flavonoids - therapeutic use ; Humans ; hyperglycemia ; hyperlipidemia ; insulin ; mechanism of action ; Models, Biological ; morbidity ; mortality ; Neuroprotective Agents - adverse effects ; Neuroprotective Agents - therapeutic use ; neuroprotective effect ; patients ; Review ; therapeutics ; vitamins ; Vitamins - adverse effects ; Vitamins - therapeutic use</subject><ispartof>Nutrients, 2016-07, Vol.8 (8), p.472</ispartof><rights>Copyright MDPI AG 2016</rights><rights>2016 by the author; licensee MDPI, Basel, Switzerland. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-e465287df0a8a4f9b58a1891f82a5cc14ea40bb7ed4a5943d181640bb82f1ec53</citedby><cites>FETCH-LOGICAL-c506t-e465287df0a8a4f9b58a1891f82a5cc14ea40bb7ed4a5943d181640bb82f1ec53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997385/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997385/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,725,778,782,790,883,27909,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27483315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Yoon Sin</creatorcontrib><title>Bioactive Compounds and Their Neuroprotective Effects in Diabetic Complications</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Hyperglycemia, hyperlipidemia and impaired insulin signaling during the development of diabetes can cause diabetic complications, such as diabetic neuropathy, resulting in significant morbidity and mortality. Although various therapeutics are available for the treatment of diabetic neuropathy, no absolute cure exists, and additional research is necessary to comprehensively understand the underlying pathophysiological pathways. A number of studies have demonstrated the potential health benefits of bioactive compounds, i.e., flavonoids and vitamins, which may be effective as supplementary treatments for diabetes and its complications. In this review, we highlight the most recent reports about the mechanisms of action of bioactive compounds (flavonoids and vitamins) possessing potential neuroprotective properties in diabetic conditions. Additional clinical studies are required to determine the appropriate dose and duration of bioactive compound supplementation for neuroprotection in diabetic patients.</description><subject>Animals</subject><subject>bioactive compounds</subject><subject>clinical trials</subject><subject>Diabetic Neuropathies - metabolism</subject><subject>Diabetic Neuropathies - prevention & control</subject><subject>diabetic neuropathy</subject><subject>Dietary Supplements - adverse effects</subject><subject>flavonoids</subject><subject>Flavonoids - adverse effects</subject><subject>Flavonoids - therapeutic use</subject><subject>Humans</subject><subject>hyperglycemia</subject><subject>hyperlipidemia</subject><subject>insulin</subject><subject>mechanism of action</subject><subject>Models, Biological</subject><subject>morbidity</subject><subject>mortality</subject><subject>Neuroprotective Agents - adverse effects</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>neuroprotective effect</subject><subject>patients</subject><subject>Review</subject><subject>therapeutics</subject><subject>vitamins</subject><subject>Vitamins - 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metabolism</topic><topic>Diabetic Neuropathies - prevention & control</topic><topic>diabetic neuropathy</topic><topic>Dietary Supplements - adverse effects</topic><topic>flavonoids</topic><topic>Flavonoids - adverse effects</topic><topic>Flavonoids - therapeutic use</topic><topic>Humans</topic><topic>hyperglycemia</topic><topic>hyperlipidemia</topic><topic>insulin</topic><topic>mechanism of action</topic><topic>Models, Biological</topic><topic>morbidity</topic><topic>mortality</topic><topic>Neuroprotective Agents - adverse effects</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>neuroprotective effect</topic><topic>patients</topic><topic>Review</topic><topic>therapeutics</topic><topic>vitamins</topic><topic>Vitamins - adverse effects</topic><topic>Vitamins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Yoon Sin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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Although various therapeutics are available for the treatment of diabetic neuropathy, no absolute cure exists, and additional research is necessary to comprehensively understand the underlying pathophysiological pathways. A number of studies have demonstrated the potential health benefits of bioactive compounds, i.e., flavonoids and vitamins, which may be effective as supplementary treatments for diabetes and its complications. In this review, we highlight the most recent reports about the mechanisms of action of bioactive compounds (flavonoids and vitamins) possessing potential neuroprotective properties in diabetic conditions. Additional clinical studies are required to determine the appropriate dose and duration of bioactive compound supplementation for neuroprotection in diabetic patients.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>27483315</pmid><doi>10.3390/nu8080472</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Animals bioactive compounds clinical trials Diabetic Neuropathies - metabolism Diabetic Neuropathies - prevention & control diabetic neuropathy Dietary Supplements - adverse effects flavonoids Flavonoids - adverse effects Flavonoids - therapeutic use Humans hyperglycemia hyperlipidemia insulin mechanism of action Models, Biological morbidity mortality Neuroprotective Agents - adverse effects Neuroprotective Agents - therapeutic use neuroprotective effect patients Review therapeutics vitamins Vitamins - adverse effects Vitamins - therapeutic use |
| title | Bioactive Compounds and Their Neuroprotective Effects in Diabetic Complications |
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