R/qtlbim: QTL with Bayesian Interval Mapping in experimental crosses

R/qtlbim is an extensible, interactive environment for the Bayesian Interval Mapping of QTL, built on top of R/qtl (Broman et al., 2003), providing Bayesian analysis of multiple interacting quantitative trait loci (QTL) models for continuous, binary and ordinal traits in experimental crosses. It inc...

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Veröffentlicht in:	Bioinformatics 2007-03, Vol.23 (5), p.641-643
Hauptverfasser:	Yandell, Brian S., Mehta, Tapan, Banerjee, Samprit, Shriner, Daniel, Venkataraman, Ramprasad, Moon, Jee Young, Neely, W. Whipple, Wu, Hao, von Smith, Randy, Yi, Nengjun
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Schlagworte:	Algorithms Bayes Theorem Chromosome Mapping Crosses, Genetic Epistasis, Genetic Markov Chains Monte Carlo Method Quantitative Trait Loci
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container_title	Bioinformatics
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creator	Yandell, Brian S. Mehta, Tapan Banerjee, Samprit Shriner, Daniel Venkataraman, Ramprasad Moon, Jee Young Neely, W. Whipple Wu, Hao von Smith, Randy Yi, Nengjun
description	R/qtlbim is an extensible, interactive environment for the Bayesian Interval Mapping of QTL, built on top of R/qtl (Broman et al., 2003), providing Bayesian analysis of multiple interacting quantitative trait loci (QTL) models for continuous, binary and ordinal traits in experimental crosses. It includes several efficient Markov chain Monte Carlo (MCMC) algorithms for evaluating the posterior of genetic architectures, i.e. the number and locations of QTL, their main and epistatic effects and gene-environment interactions. R/qtlbim provides extensive informative graphical and numerical summaries, and model selection and convergence diagnostics of the MCMC output, illustrated through the vignette, example and demo capabilities of R (R Development Core Team 2006). Availability: The package is freely available from cran.r-project.org. Contact: byandell@wisc.edu or nyi@ms.soph.uab.edu
doi_str_mv	10.1093/bioinformatics/btm011
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subjects	Algorithms Bayes Theorem Chromosome Mapping Crosses, Genetic Epistasis, Genetic Markov Chains Monte Carlo Method Quantitative Trait Loci
title	R/qtlbim: QTL with Bayesian Interval Mapping in experimental crosses
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