OPG‐Fc but Not Zoledronic Acid Discontinuation Reverses Osteonecrosis of the Jaws (ONJ) in Mice

ABSTRACT Osteonecrosis of the jaws (ONJ) is a significant complication of antiresorptive medications, such as bisphosphonates and denosumab. Antiresorptive discontinuation to promote healing of ONJ lesions remains highly controversial and understudied. Here, we investigated whether antiresorptive di...

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Veröffentlicht in:Journal of bone and mineral research 2015-09, Vol.30 (9), p.1627-1640
Hauptverfasser: de Molon, Rafael Scaf, Shimamoto, Hiroaki, Bezouglaia, Olga, Pirih, Flavia Q, Dry, Sarah M, Kostenuik, Paul, Boyce, Rogely W, Dwyer, Denise, Aghaloo, Tara L, Tetradis, Sotirios
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Sprache:eng
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