Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats
The aim of this study was to investigate the involvement of androgen, mainly testosterone, in the expression of renal senescence marker protein-30 (SMP30) in male rats. We found that the renal SMP30 expression was up-regulated by endogenous testosterone stimulation during puberty. Interestingly, and...
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| Veröffentlicht in: | Scientific reports 2016-08, Vol.6 (1), p.32085-32085, Article 32085 |
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| creator | Lin, Po-Han Jian, Cai-Yun Chou, Jou-Chun Chen, Chien-Wei Chen, Chih-Chieh Soong, Christina Hu, Sindy Lieu, Fu-Kong Wang, Paulus S. Wang, Shyi-Wu |
| description | The aim of this study was to investigate the involvement of androgen, mainly testosterone, in the expression of renal senescence marker protein-30 (SMP30) in male rats. We found that the renal SMP30 expression was up-regulated by endogenous testosterone stimulation during puberty. Interestingly, androgen-deficient orchidectomized (ORX) rats exhibited lower SMP30 mRNA and protein expression in the kidney, and that was restored by testosterone propionate (TP) replacement. Abrogation of androgen receptor (AR) activity by co-treatment with flutamide abolished testosterone-induced SMP30 expression in the kidney as well as in the NRK52E cells. However, SMP30 expression was unaltered in the liver of ORX rats. We also showed a positive correlation between renal SMP30 expression and plasma testosterone level during the aging process. TP-induced SMP30 expression in ovariectomized (OVX) rats was observed and was an evidence to explain the gender difference of SMP30 levels. Immunofluorescence assay showed that renal SMP30 was specifically expressed in the proximal tubular segments of the kidney. The urinary Ca
2+
level was increased in both ORX and male aging rats. Taken together, our results indicate a novel role of testosterone in regulating SMP30 expression specifically in the kidney to contribute to urinary calcium absorption. |
| doi_str_mv | 10.1038/srep32085 |
| format | Article |
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2+
level was increased in both ORX and male aging rats. Taken together, our results indicate a novel role of testosterone in regulating SMP30 expression specifically in the kidney to contribute to urinary calcium absorption.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep32085</identifier><identifier>PMID: 27553527</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/34 ; 38/77 ; 631/443/272 ; 631/443/7 ; 82/29 ; 82/80 ; Absorption ; Aging ; Aging - physiology ; Androgen receptors ; Androgens ; Animals ; Calcium ; Calcium (urinary) ; Calcium - urine ; Calcium absorption ; Calcium-Binding Proteins - genetics ; Calcium-Binding Proteins - metabolism ; Calcium-Transporting ATPases - metabolism ; Female ; Flutamide ; Gene expression ; Humanities and Social Sciences ; Immunofluorescence ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - metabolism ; Kidney - drug effects ; Kidney - metabolism ; Kidneys ; Liver ; Liver - drug effects ; Liver - metabolism ; Male ; mRNA ; multidisciplinary ; Orchiectomy ; Ovariectomy ; Propionic acid ; Proteins ; Puberty ; Rats, Sprague-Dawley ; Receptors, Androgen - metabolism ; Rodents ; Science ; Science (multidisciplinary) ; Senescence ; Testosterone ; Testosterone - metabolism ; Testosterone propionate ; Testosterone Propionate - pharmacology</subject><ispartof>Scientific reports, 2016-08, Vol.6 (1), p.32085-32085, Article 32085</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Aug 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-2e6065b2b20ee6aa3d4bf060619a4b075840e7d33de55ae335155c8b47282f7b3</citedby><cites>FETCH-LOGICAL-c438t-2e6065b2b20ee6aa3d4bf060619a4b075840e7d33de55ae335155c8b47282f7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995462/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995462/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27553527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Po-Han</creatorcontrib><creatorcontrib>Jian, Cai-Yun</creatorcontrib><creatorcontrib>Chou, Jou-Chun</creatorcontrib><creatorcontrib>Chen, Chien-Wei</creatorcontrib><creatorcontrib>Chen, Chih-Chieh</creatorcontrib><creatorcontrib>Soong, Christina</creatorcontrib><creatorcontrib>Hu, Sindy</creatorcontrib><creatorcontrib>Lieu, Fu-Kong</creatorcontrib><creatorcontrib>Wang, Paulus S.</creatorcontrib><creatorcontrib>Wang, Shyi-Wu</creatorcontrib><title>Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The aim of this study was to investigate the involvement of androgen, mainly testosterone, in the expression of renal senescence marker protein-30 (SMP30) in male rats. We found that the renal SMP30 expression was up-regulated by endogenous testosterone stimulation during puberty. Interestingly, androgen-deficient orchidectomized (ORX) rats exhibited lower SMP30 mRNA and protein expression in the kidney, and that was restored by testosterone propionate (TP) replacement. Abrogation of androgen receptor (AR) activity by co-treatment with flutamide abolished testosterone-induced SMP30 expression in the kidney as well as in the NRK52E cells. However, SMP30 expression was unaltered in the liver of ORX rats. We also showed a positive correlation between renal SMP30 expression and plasma testosterone level during the aging process. TP-induced SMP30 expression in ovariectomized (OVX) rats was observed and was an evidence to explain the gender difference of SMP30 levels. Immunofluorescence assay showed that renal SMP30 was specifically expressed in the proximal tubular segments of the kidney. The urinary Ca
2+
level was increased in both ORX and male aging rats. Taken together, our results indicate a novel role of testosterone in regulating SMP30 expression specifically in the kidney to contribute to urinary calcium absorption.</description><subject>14/34</subject><subject>38/77</subject><subject>631/443/272</subject><subject>631/443/7</subject><subject>82/29</subject><subject>82/80</subject><subject>Absorption</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Androgen receptors</subject><subject>Androgens</subject><subject>Animals</subject><subject>Calcium</subject><subject>Calcium (urinary)</subject><subject>Calcium - urine</subject><subject>Calcium absorption</subject><subject>Calcium-Binding Proteins - genetics</subject><subject>Calcium-Binding Proteins - metabolism</subject><subject>Calcium-Transporting ATPases - metabolism</subject><subject>Female</subject><subject>Flutamide</subject><subject>Gene expression</subject><subject>Humanities and Social Sciences</subject><subject>Immunofluorescence</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - metabolism</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>mRNA</subject><subject>multidisciplinary</subject><subject>Orchiectomy</subject><subject>Ovariectomy</subject><subject>Propionic acid</subject><subject>Proteins</subject><subject>Puberty</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Androgen - metabolism</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Senescence</subject><subject>Testosterone</subject><subject>Testosterone - metabolism</subject><subject>Testosterone propionate</subject><subject>Testosterone Propionate - pharmacology</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkdtqFTEUhoMottRe-AIS8KYVRjM5zOFGkFK10FJBvQ5JZk1NnZ2MKxnpfg2f2OzuutlqbhLW-vKvw0_I85q9rpno3iSEWXDWqUfkkDOpKi44f7z3PiDHKd2ychTvZd0_JQe8VUoo3h6SXxdhWFz2MdA4UoRgJpogQHIQHNCVwe-AdMaYwYdKMHry-eqTYKcU7maElDYf7ZpmSDmmDBgDUBMG6nOiLoaM3i736jnSBX0wuKbOTM4vK2psijjfZ30opSagaHJ6Rp6MZkpw_HAfka_vz7-cfawurz9cnL27rJwUXa44NKxRllvOABpjxCDtyEqs7o20rFWdZNAOQgyglAEhVK2U66xsecfH1ooj8narOy92BUMZOKOZ9Iy-TL3W0Xj9dyb4b_om_tSy75VseBE4eRDA-GMpG9ArX_Y2TSZAXJKuu1rWUvK-KejLf9DbuGBZ9obqu6ZQqi3U6ZZyGFPxddw1UzO9MVvvzC7si_3ud-Qfawvwagukkgo3gHsl_1P7DVa8tZI</recordid><startdate>20160824</startdate><enddate>20160824</enddate><creator>Lin, Po-Han</creator><creator>Jian, Cai-Yun</creator><creator>Chou, Jou-Chun</creator><creator>Chen, Chien-Wei</creator><creator>Chen, Chih-Chieh</creator><creator>Soong, Christina</creator><creator>Hu, Sindy</creator><creator>Lieu, Fu-Kong</creator><creator>Wang, Paulus S.</creator><creator>Wang, Shyi-Wu</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160824</creationdate><title>Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats</title><author>Lin, Po-Han ; Jian, Cai-Yun ; Chou, Jou-Chun ; Chen, Chien-Wei ; Chen, Chih-Chieh ; Soong, Christina ; Hu, Sindy ; Lieu, Fu-Kong ; Wang, Paulus S. ; Wang, Shyi-Wu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-2e6065b2b20ee6aa3d4bf060619a4b075840e7d33de55ae335155c8b47282f7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>14/34</topic><topic>38/77</topic><topic>631/443/272</topic><topic>631/443/7</topic><topic>82/29</topic><topic>82/80</topic><topic>Absorption</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Androgen receptors</topic><topic>Androgens</topic><topic>Animals</topic><topic>Calcium</topic><topic>Calcium (urinary)</topic><topic>Calcium - urine</topic><topic>Calcium absorption</topic><topic>Calcium-Binding Proteins - genetics</topic><topic>Calcium-Binding Proteins - metabolism</topic><topic>Calcium-Transporting ATPases - metabolism</topic><topic>Female</topic><topic>Flutamide</topic><topic>Gene expression</topic><topic>Humanities and Social Sciences</topic><topic>Immunofluorescence</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - metabolism</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidneys</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>mRNA</topic><topic>multidisciplinary</topic><topic>Orchiectomy</topic><topic>Ovariectomy</topic><topic>Propionic acid</topic><topic>Proteins</topic><topic>Puberty</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Androgen - metabolism</topic><topic>Rodents</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Senescence</topic><topic>Testosterone</topic><topic>Testosterone - metabolism</topic><topic>Testosterone propionate</topic><topic>Testosterone Propionate - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Po-Han</creatorcontrib><creatorcontrib>Jian, Cai-Yun</creatorcontrib><creatorcontrib>Chou, Jou-Chun</creatorcontrib><creatorcontrib>Chen, Chien-Wei</creatorcontrib><creatorcontrib>Chen, Chih-Chieh</creatorcontrib><creatorcontrib>Soong, Christina</creatorcontrib><creatorcontrib>Hu, Sindy</creatorcontrib><creatorcontrib>Lieu, Fu-Kong</creatorcontrib><creatorcontrib>Wang, Paulus S.</creatorcontrib><creatorcontrib>Wang, Shyi-Wu</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Po-Han</au><au>Jian, Cai-Yun</au><au>Chou, Jou-Chun</au><au>Chen, Chien-Wei</au><au>Chen, Chih-Chieh</au><au>Soong, Christina</au><au>Hu, Sindy</au><au>Lieu, Fu-Kong</au><au>Wang, Paulus S.</au><au>Wang, Shyi-Wu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-08-24</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>32085</spage><epage>32085</epage><pages>32085-32085</pages><artnum>32085</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The aim of this study was to investigate the involvement of androgen, mainly testosterone, in the expression of renal senescence marker protein-30 (SMP30) in male rats. We found that the renal SMP30 expression was up-regulated by endogenous testosterone stimulation during puberty. Interestingly, androgen-deficient orchidectomized (ORX) rats exhibited lower SMP30 mRNA and protein expression in the kidney, and that was restored by testosterone propionate (TP) replacement. Abrogation of androgen receptor (AR) activity by co-treatment with flutamide abolished testosterone-induced SMP30 expression in the kidney as well as in the NRK52E cells. However, SMP30 expression was unaltered in the liver of ORX rats. We also showed a positive correlation between renal SMP30 expression and plasma testosterone level during the aging process. TP-induced SMP30 expression in ovariectomized (OVX) rats was observed and was an evidence to explain the gender difference of SMP30 levels. Immunofluorescence assay showed that renal SMP30 was specifically expressed in the proximal tubular segments of the kidney. The urinary Ca
2+
level was increased in both ORX and male aging rats. Taken together, our results indicate a novel role of testosterone in regulating SMP30 expression specifically in the kidney to contribute to urinary calcium absorption.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27553527</pmid><doi>10.1038/srep32085</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 14/34 38/77 631/443/272 631/443/7 82/29 82/80 Absorption Aging Aging - physiology Androgen receptors Androgens Animals Calcium Calcium (urinary) Calcium - urine Calcium absorption Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Calcium-Transporting ATPases - metabolism Female Flutamide Gene expression Humanities and Social Sciences Immunofluorescence Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kidney - drug effects Kidney - metabolism Kidneys Liver Liver - drug effects Liver - metabolism Male mRNA multidisciplinary Orchiectomy Ovariectomy Propionic acid Proteins Puberty Rats, Sprague-Dawley Receptors, Androgen - metabolism Rodents Science Science (multidisciplinary) Senescence Testosterone Testosterone - metabolism Testosterone propionate Testosterone Propionate - pharmacology |
| title | Induction of renal senescence marker protein-30 (SMP30) expression by testosterone and its contribution to urinary calcium absorption in male rats |
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