Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses
Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO. This meta-analysis aimed to identify the association between...
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description | Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO. This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results. A systematic literature search was conducted in relevant database. Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients. We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval. Total 17 studies including 12 OS markers were adopted. The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group. In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO. |
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This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results. A systematic literature search was conducted in relevant database. Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients. We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval. Total 17 studies including 12 OS markers were adopted. The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group. In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2016/7067984</identifier><identifier>PMID: 27594735</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Biological markers ; Biomarkers - metabolism ; Care and treatment ; Development and progression ; Female ; Genetic aspects ; Health aspects ; Humans ; Osteoporosis ; Osteoporosis, Postmenopausal - diagnosis ; Osteoporosis, Postmenopausal - metabolism ; Oxidative Stress ; Postmenopausal women ; Review</subject><ispartof>Disease markers, 2016-01, Vol.2016 (2016), p.1-12</ispartof><rights>Copyright © 2016 Qiaozhen Zhou et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Qiaozhen Zhou et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-ca14886f067d37cd701d49c6cc2c5adb138219ee49feb7770f9b43ee5dcab21d3</citedby><cites>FETCH-LOGICAL-c471t-ca14886f067d37cd701d49c6cc2c5adb138219ee49feb7770f9b43ee5dcab21d3</cites><orcidid>0000-0003-0395-0952 ; 0000-0003-4522-2769</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995322/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995322/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27594735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bamonti, Fabrizia</contributor><creatorcontrib>Huang, Shengbin</creatorcontrib><creatorcontrib>Ma, Jianfeng</creatorcontrib><creatorcontrib>Mao, Yixin</creatorcontrib><creatorcontrib>Dai, Panpan</creatorcontrib><creatorcontrib>Li, Qiao</creatorcontrib><creatorcontrib>Li, Ning</creatorcontrib><creatorcontrib>Zhang, Dafeng</creatorcontrib><creatorcontrib>Zhu, Li</creatorcontrib><creatorcontrib>Zhou, Qiaozhen</creatorcontrib><creatorcontrib>Li, Xumin</creatorcontrib><title>Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO. This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results. A systematic literature search was conducted in relevant database. Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients. We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval. Total 17 studies including 12 OS markers were adopted. The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group. In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO.</description><subject>Biological markers</subject><subject>Biomarkers - metabolism</subject><subject>Care and treatment</subject><subject>Development and progression</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Osteoporosis</subject><subject>Osteoporosis, Postmenopausal - diagnosis</subject><subject>Osteoporosis, Postmenopausal - metabolism</subject><subject>Oxidative Stress</subject><subject>Postmenopausal women</subject><subject>Review</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc9rFDEYhoNY7Lp68ywBLwUdm5-TxENhLVqFykqr55BJvmmjM5N1Mrt1_3uz7Fr1JgQCycOT782L0DNKXlMq5SkjtD5VpFZGiwdoRrWSla45eYhmhCldESbIMXqc8zdCKDPCPELHTEkjFJczFJc_Y3BT3AC-nkbIubqCzk0Q8NuYejd-hzHjOODPKU89DGnl1tl1eJknSKs0phzzG7zA19ty0BePx1ewiXCH3RDwJ5hctRhct82Qn6Cj1nUZnh72Ofr6_t2X8w_V5fLi4_nisvJC0anyjgqt67YEClz5oAgNwvjae-alCw3lmlEDIEwLjVKKtKYRHEAG7xpGA5-js713tW56CB6GaXSdXY2xxNna5KL992aIt_YmbawwRnLGiuDkIBjTjzXkyfYxe-g6N0BaZ0s1VVJKXtYcvdijN64DG4c2FaPf4XYhidaCCqkL9WpP-fJfeYT2fhhK7K5Du-vQHjos-PO_A9zDv0srwMs9cBuH4O7if-pKP-Vt94emhCtJ-S9cZ6_H</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Huang, Shengbin</creator><creator>Ma, Jianfeng</creator><creator>Mao, Yixin</creator><creator>Dai, Panpan</creator><creator>Li, Qiao</creator><creator>Li, Ning</creator><creator>Zhang, Dafeng</creator><creator>Zhu, Li</creator><creator>Zhou, Qiaozhen</creator><creator>Li, Xumin</creator><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0395-0952</orcidid><orcidid>https://orcid.org/0000-0003-4522-2769</orcidid></search><sort><creationdate>20160101</creationdate><title>Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses</title><author>Huang, Shengbin ; Ma, Jianfeng ; Mao, Yixin ; Dai, Panpan ; Li, Qiao ; Li, Ning ; Zhang, Dafeng ; Zhu, Li ; Zhou, Qiaozhen ; Li, Xumin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-ca14886f067d37cd701d49c6cc2c5adb138219ee49feb7770f9b43ee5dcab21d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biological markers</topic><topic>Biomarkers - metabolism</topic><topic>Care and treatment</topic><topic>Development and progression</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Osteoporosis</topic><topic>Osteoporosis, Postmenopausal - diagnosis</topic><topic>Osteoporosis, Postmenopausal - metabolism</topic><topic>Oxidative Stress</topic><topic>Postmenopausal women</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Shengbin</creatorcontrib><creatorcontrib>Ma, Jianfeng</creatorcontrib><creatorcontrib>Mao, Yixin</creatorcontrib><creatorcontrib>Dai, Panpan</creatorcontrib><creatorcontrib>Li, Qiao</creatorcontrib><creatorcontrib>Li, Ning</creatorcontrib><creatorcontrib>Zhang, Dafeng</creatorcontrib><creatorcontrib>Zhu, Li</creatorcontrib><creatorcontrib>Zhou, Qiaozhen</creatorcontrib><creatorcontrib>Li, Xumin</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Shengbin</au><au>Ma, Jianfeng</au><au>Mao, Yixin</au><au>Dai, Panpan</au><au>Li, Qiao</au><au>Li, Ning</au><au>Zhang, Dafeng</au><au>Zhu, Li</au><au>Zhou, Qiaozhen</au><au>Li, Xumin</au><au>Bamonti, Fabrizia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO. This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results. A systematic literature search was conducted in relevant database. Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients. We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval. Total 17 studies including 12 OS markers were adopted. The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group. In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>27594735</pmid><doi>10.1155/2016/7067984</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-0395-0952</orcidid><orcidid>https://orcid.org/0000-0003-4522-2769</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biological markers Biomarkers - metabolism Care and treatment Development and progression Female Genetic aspects Health aspects Humans Osteoporosis Osteoporosis, Postmenopausal - diagnosis Osteoporosis, Postmenopausal - metabolism Oxidative Stress Postmenopausal women Review |
title | Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses |
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