Methylome-wide Analysis of Chronic HIV Infection Reveals Five-Year Increase in Biological Age and Epigenetic Targeting of HLA

HIV-infected individuals are living longer on antiretroviral therapy, but many patients display signs that in some ways resemble premature aging. To investigate and quantify the impact of chronic HIV infection on aging, we report a global analysis of the whole-blood DNA methylomes of 137 HIV+ indivi...

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Veröffentlicht in:	Molecular cell 2016-04, Vol.62 (2), p.157-168
Hauptverfasser:	Gross, Andrew M., Jaeger, Philipp A., Kreisberg, Jason F., Licon, Katherine, Jepsen, Kristen L., Khosroheidari, Mahdieh, Morsey, Brenda M., Swindells, Susan, Shen, Hui, Ng, Cherie T., Flagg, Ken, Chen, Daniel, Zhang, Kang, Fox, Howard S., Ideker, Trey
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - immunology Anti-HIV Agents - therapeutic use antiretroviral agents Case-Control Studies CD4-CD8 Ratio CD8-positive T-lymphocytes Chronic Disease CpG Islands disease course Disease Progression DNA DNA Methylation Epigenesis, Genetic epigenetics Gene Expression Profiling Genome-Wide Association Study Genotype HIV infections HIV Infections - diagnosis HIV Infections - drug therapy HIV Infections - genetics HIV Infections - immunology HIV Infections - mortality HLA antigens HLA Antigens - genetics HLA Antigens - immunology Human immunodeficiency virus Humans loci methylation Models, Genetic mortality patients Phenotype risk Risk Factors therapeutics Time Factors Treatment Outcome
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