Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

Donor CD4(+)Foxp3(+) regulatory T cells (T reg cells) suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (HCT [allo-HCT]). Current clinical study protocols rely on the ex vivo expansion of donor T reg cells and their infusion in high numbers. In this s...

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Veröffentlicht in:	The Journal of experimental medicine 2016-08, Vol.213 (9), p.1881-1900
Hauptverfasser:	Chopra, Martin, Biehl, Marlene, Steinfatt, Tim, Brandl, Andreas, Kums, Juliane, Amich, Jorge, Vaeth, Martin, Kuen, Janina, Holtappels, Rafaela, Podlech, Jürgen, Mottok, Anja, Kraus, Sabrina, Jordán-Garrote, Ana-Laura, Bäuerlein, Carina A, Brede, Christian, Ribechini, Eliana, Fick, Andrea, Seher, Axel, Polz, Johannes, Ottmüller, Katja J, Baker, Jeanette, Nishikii, Hidekazu, Ritz, Miriam, Mattenheimer, Katharina, Schwinn, Stefanie, Winter, Thorsten, Schäfer, Viktoria, Krappmann, Sven, Einsele, Hermann, Müller, Thomas D, Reddehase, Matthias J, Lutz, Manfred B, Männel, Daniela N, Berberich-Siebelt, Friederike, Wajant, Harald, Beilhack, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Female Graft vs Host Disease - immunology Graft vs Host Disease - prevention & control Hematopoietic Stem Cell Transplantation Interleukin-2 - pharmacology Mice Mice, Inbred Strains Myeloid-Derived Suppressor Cells - physiology Receptors, Tumor Necrosis Factor, Type II - physiology T-Lymphocytes, Regulatory - immunology
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