The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis

Renal tubulointerstitial fibrosis (TIF) is the final pathway of various renal injuries that result in chronic kidney disease. The mammalian Hippo-Salvador signaling pathway has been implicated in the regulation of cell proliferation, cell death, tissue regeneration, and tumorigenesis. Here, we repor...

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Veröffentlicht in:	Scientific reports 2016-08, Vol.6 (1), p.31931, Article 31931
Hauptverfasser:	Seo, Eunjeong, Kim, Wan-Young, Hur, Jeongmi, Kim, Hanbyul, Nam, Sun Ah, Choi, Arum, Kim, Yu-Mi, Park, Sang Hee, Chung, Chaeuk, Kim, Jin, Min, Soohong, Myung, Seung-Jae, Lim, Dae-Sik, Kim, Yong Kyun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/304 692/4022/1585/3182 692/699/1585/3182 Animals Apoptosis beta Catenin - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell death Cell proliferation Disease Models, Animal Epithelial-Mesenchymal Transition Fibrosis Gene Deletion Gene Expression Regulation Humanities and Social Sciences Humans Kidney Diseases - genetics Kidney Diseases - metabolism Kidney Diseases - pathology Kidney transplantation Kidney Tubules - metabolism Kidney Tubules - pathology Mesenchyme Mice multidisciplinary Protein-Serine-Threonine Kinases - metabolism Rodents Science Science (multidisciplinary) Signal Transduction Transcription Transcription Factors - metabolism Transforming growth factor Transforming Growth Factor beta - metabolism Tumorigenesis β-Catenin
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