Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

Development of HIV-1 prevention methods is a global priority. In this randomized, controlled trial in sub-Saharan Africa, a vaginal ring containing the antiretroviral dapivirine was 27% effective in protecting against HIV-1 acquisition. More than half of the 35 million persons currently living with...

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Veröffentlicht in:	The New England journal of medicine 2016-12, Vol.375 (22), p.2121-2132
Hauptverfasser:	Baeten, Jared M, Palanee-Phillips, Thesla, Brown, Elizabeth R, Schwartz, Katie, Soto-Torres, Lydia E, Govender, Vaneshree, Mgodi, Nyaradzo M, Matovu Kiweewa, Flavia, Nair, Gonasagrie, Mhlanga, Felix, Siva, Samantha, Bekker, Linda-Gail, Jeenarain, Nitesha, Gaffoor, Zakir, Martinson, Francis, Makanani, Bonus, Pather, Arendevi, Naidoo, Logashvari, Husnik, Marla, Richardson, Barbra A, Parikh, Urvi M, Mellors, John W, Marzinke, Mark A, Hendrix, Craig W, van der Straten, Ariane, Ramjee, Gita, Chirenje, Zvavahera M, Nakabiito, Clemensia, Taha, Taha E, Jones, Judith, Mayo, Ashley, Scheckter, Rachel, Berthiaume, Jennifer, Livant, Edward, Jacobson, Cindy, Ndase, Patrick, White, Rhonda, Patterson, Karen, Germuga, Donna, Galaska, Beth, Bunge, Katherine, Singh, Devika, Szydlo, Daniel W, Montgomery, Elizabeth T, Mensch, Barbara S, Torjesen, Kristine, Grossman, Cynthia I, Chakhtoura, Nahida, Nel, Annalene, Rosenberg, Zeda, McGowan, Ian, Hillier, Sharon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Africa, Southern - epidemiology Age Factors Antiretroviral drugs Clinical trials Data processing Disease prevention Double-Blind Method Drug delivery Drug Resistance, Viral Female HIV HIV Infections - epidemiology HIV Infections - prevention & control HIV-1 Human immunodeficiency virus Humans Incidence Middle Aged Patient Compliance Prophylaxis Pyrimidines - administration & dosage Pyrimidines - adverse effects Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - adverse effects Vagina Viral infections Women Young Adult
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