Excess free histone H3 localizes to centrosomes for proteasome-mediated degradation during mitosis in metazoans

The cell tightly controls histone protein levels in order to achieve proper packaging of the genome into chromatin, while avoiding the deleterious consequences of excess free histones. Our accompanying study has shown that a histone modification that loosens the intrinsic structure of the nucleosome...

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Veröffentlicht in:	Cell cycle (Georgetown, Tex.) Tex.), 2016-08, Vol.15 (16), p.2216-2225
Hauptverfasser:	Wike, Candice L, Graves, Hillary K, Wason, Arpit, Hawkins, Reva, Gopalakrishnan, Jay, Schumacher, Jill, Tyler, Jessica K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - metabolism Centrosome - drug effects Centrosome - metabolism HeLa Cells Histones - metabolism Humans Mitosis - drug effects Models, Biological Mutation - genetics Polo-Like Kinase 1 Proteasome Inhibitors - pharmacology Protein Serine-Threonine Kinases - metabolism Proteolysis - drug effects Proto-Oncogene Proteins - metabolism Ubiquitin - metabolism Ubiquitination
Online-Zugang:	Volltext
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