The relationship between nuclear factor (NF)-κB family gene expression and prognosis in triple-negative breast cancer (TNBC) patients receiving adjuvant doxorubicin treatment
We investigated gene expression profiles of the NF-κB pathway in patients with triple-negative breast cancer (TNBC) receiving adjuvant chemotherapy to determine the prognostic value of NF-κB pathway genes according to chemotherapeutic regimen. We used the nCounter expression assay to measure express...
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| creator | Kim, Ji-Yeon Jung, Hae Hyun Ahn, Soomin Bae, SooYoun Lee, Se Kyung Kim, Seok Won Lee, Jeong Eon Nam, Seok Jin Ahn, Jin Seok Im, Young-Hyuck Park, Yeon Hee |
| description | We investigated gene expression profiles of the NF-κB pathway in patients with triple-negative breast cancer (TNBC) receiving adjuvant chemotherapy to determine the prognostic value of NF-κB pathway genes according to chemotherapeutic regimen. We used the nCounter expression assay to measure expression of 11 genes (NFKB1, NFKB2, RELA, RELB, REL, TP53, FOXC1, TBP, SP1, STAT3 and IRF1 genes) belonging to the NF-κB pathway using mRNA extracted from paraffin-embedded tumor tissues from 203 patients diagnosed with TNBC. Of the 203 patients, 116 were treated with a chemotherapeutic regimen containing doxorubicin. As revealed by the expression profiles of the 11 genes, increased expression of SP1 was associated with poor prognosis in TNBC patients treated with adjuvant doxorubicin chemotherapy (5-year distant recurrence-free survival [5Y DRFS], low vs. high expression [cut-off: median]: 92.3% vs. 71.6%,
P
= 0.001). In a multivariate Cox regression model, SP1 expression was a useful marker for predicting long-term prognosis in TNBC patients receiving doxorubicin treatment, and we thus suggest that SP1 expression could serve as a prognostic marker in these patients. |
| doi_str_mv | 10.1038/srep31804 |
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P
= 0.001). In a multivariate Cox regression model, SP1 expression was a useful marker for predicting long-term prognosis in TNBC patients receiving doxorubicin treatment, and we thus suggest that SP1 expression could serve as a prognostic marker in these patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep31804</identifier><identifier>PMID: 27545642</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/4028/67/1347 ; 692/4028/67/69 ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biomarkers, Tumor - genetics ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Doxorubicin - administration & dosage ; Female ; Gene Expression Profiling - methods ; Gene Expression Regulation, Neoplastic ; Humanities and Social Sciences ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; multidisciplinary ; NF-kappa B - genetics ; Prognosis ; Retrospective Studies ; Science ; Science (multidisciplinary) ; Signal Transduction - genetics ; Sp1 Transcription Factor - genetics ; Triple Negative Breast Neoplasms - drug therapy ; Triple Negative Breast Neoplasms - genetics ; Triple Negative Breast Neoplasms - surgery ; Young Adult</subject><ispartof>Scientific reports, 2016-08, Vol.6 (1), p.31804-31804, Article 31804</ispartof><rights>The Author(s) 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-d5a150e11b9a83d51a79b77c2375b085e12a353dee4e30151d1bda5d5501dee13</citedby><cites>FETCH-LOGICAL-c410t-d5a150e11b9a83d51a79b77c2375b085e12a353dee4e30151d1bda5d5501dee13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992884/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4992884/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27545642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Ji-Yeon</creatorcontrib><creatorcontrib>Jung, Hae Hyun</creatorcontrib><creatorcontrib>Ahn, Soomin</creatorcontrib><creatorcontrib>Bae, SooYoun</creatorcontrib><creatorcontrib>Lee, Se Kyung</creatorcontrib><creatorcontrib>Kim, Seok Won</creatorcontrib><creatorcontrib>Lee, Jeong Eon</creatorcontrib><creatorcontrib>Nam, Seok Jin</creatorcontrib><creatorcontrib>Ahn, Jin Seok</creatorcontrib><creatorcontrib>Im, Young-Hyuck</creatorcontrib><creatorcontrib>Park, Yeon Hee</creatorcontrib><title>The relationship between nuclear factor (NF)-κB family gene expression and prognosis in triple-negative breast cancer (TNBC) patients receiving adjuvant doxorubicin treatment</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>We investigated gene expression profiles of the NF-κB pathway in patients with triple-negative breast cancer (TNBC) receiving adjuvant chemotherapy to determine the prognostic value of NF-κB pathway genes according to chemotherapeutic regimen. We used the nCounter expression assay to measure expression of 11 genes (NFKB1, NFKB2, RELA, RELB, REL, TP53, FOXC1, TBP, SP1, STAT3 and IRF1 genes) belonging to the NF-κB pathway using mRNA extracted from paraffin-embedded tumor tissues from 203 patients diagnosed with TNBC. Of the 203 patients, 116 were treated with a chemotherapeutic regimen containing doxorubicin. As revealed by the expression profiles of the 11 genes, increased expression of SP1 was associated with poor prognosis in TNBC patients treated with adjuvant doxorubicin chemotherapy (5-year distant recurrence-free survival [5Y DRFS], low vs. high expression [cut-off: median]: 92.3% vs. 71.6%,
P
= 0.001). In a multivariate Cox regression model, SP1 expression was a useful marker for predicting long-term prognosis in TNBC patients receiving doxorubicin treatment, and we thus suggest that SP1 expression could serve as a prognostic marker in these patients.</description><subject>692/4028/67/1347</subject><subject>692/4028/67/69</subject><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Chemotherapy, Adjuvant</subject><subject>Combined Modality Therapy</subject><subject>Doxorubicin - administration & dosage</subject><subject>Female</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>NF-kappa B - genetics</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Signal Transduction - genetics</subject><subject>Sp1 Transcription Factor - genetics</subject><subject>Triple Negative Breast Neoplasms - drug therapy</subject><subject>Triple Negative Breast Neoplasms - genetics</subject><subject>Triple Negative Breast Neoplasms - surgery</subject><subject>Young Adult</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNptkc1u1DAURiMEolXpghdAXnaQAr52PEk2SHREAakqm2FtOfadjEeJHWxn2j4Vex6CZ8IwZVQkvPHPPT7X8lcUL4G-AcqbtzHgxKGh1ZPilNFKlIwz9vTR-qQ4j3FH8xCsraB9XpywWlRiWbHT4vt6iyTgoJL1Lm7tRDpMt4iOuFkPqALZKJ18IBc3V4vy54_LvB_tcE96dEjwbgoYY75KlDNkCr53PtpIrCMp2GnA0mGf3XskXUAVE9HKacy69c3lakGmXEOXYn6CRru3rifK7Oa9cokYf-fD3Fn9R4YqjZl8UTzbqCHi-cN8Vny9-rBefSqvv3z8vHp_XeoKaCqNUCAoAnStargRoOq2q2vNeC062ggEprjgBrFCTkGAgc4oYYSgkA-BnxXvDt5p7kY0OrcOapBTsKMK99IrK_-tOLuVvd_Lqm1Z01RZcPEgCP7bjDHJ0UaNw6Ac-jlKaIAvGYjlMqOLA6qDjznOzbENUPk7Y3nMOLOvHr_rSP5NNAOvD0DMJddjkDs_B5f_6j-2X5z6teM</recordid><startdate>20160822</startdate><enddate>20160822</enddate><creator>Kim, Ji-Yeon</creator><creator>Jung, Hae Hyun</creator><creator>Ahn, Soomin</creator><creator>Bae, SooYoun</creator><creator>Lee, Se Kyung</creator><creator>Kim, Seok Won</creator><creator>Lee, Jeong Eon</creator><creator>Nam, Seok Jin</creator><creator>Ahn, Jin Seok</creator><creator>Im, Young-Hyuck</creator><creator>Park, Yeon Hee</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160822</creationdate><title>The relationship between nuclear factor (NF)-κB family gene expression and prognosis in triple-negative breast cancer (TNBC) patients receiving adjuvant doxorubicin treatment</title><author>Kim, Ji-Yeon ; Jung, Hae Hyun ; Ahn, Soomin ; Bae, SooYoun ; Lee, Se Kyung ; Kim, Seok Won ; Lee, Jeong Eon ; Nam, Seok Jin ; Ahn, Jin Seok ; Im, Young-Hyuck ; Park, Yeon Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-d5a150e11b9a83d51a79b77c2375b085e12a353dee4e30151d1bda5d5501dee13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>692/4028/67/1347</topic><topic>692/4028/67/69</topic><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Chemotherapy, Adjuvant</topic><topic>Combined Modality Therapy</topic><topic>Doxorubicin - administration & dosage</topic><topic>Female</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>NF-kappa B - genetics</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Signal Transduction - genetics</topic><topic>Sp1 Transcription Factor - genetics</topic><topic>Triple Negative Breast Neoplasms - drug therapy</topic><topic>Triple Negative Breast Neoplasms - genetics</topic><topic>Triple Negative Breast Neoplasms - surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Ji-Yeon</creatorcontrib><creatorcontrib>Jung, Hae Hyun</creatorcontrib><creatorcontrib>Ahn, Soomin</creatorcontrib><creatorcontrib>Bae, SooYoun</creatorcontrib><creatorcontrib>Lee, Se Kyung</creatorcontrib><creatorcontrib>Kim, Seok Won</creatorcontrib><creatorcontrib>Lee, Jeong Eon</creatorcontrib><creatorcontrib>Nam, Seok Jin</creatorcontrib><creatorcontrib>Ahn, Jin Seok</creatorcontrib><creatorcontrib>Im, Young-Hyuck</creatorcontrib><creatorcontrib>Park, Yeon Hee</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Ji-Yeon</au><au>Jung, Hae Hyun</au><au>Ahn, Soomin</au><au>Bae, SooYoun</au><au>Lee, Se Kyung</au><au>Kim, Seok Won</au><au>Lee, Jeong Eon</au><au>Nam, Seok Jin</au><au>Ahn, Jin Seok</au><au>Im, Young-Hyuck</au><au>Park, Yeon Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between nuclear factor (NF)-κB family gene expression and prognosis in triple-negative breast cancer (TNBC) patients receiving adjuvant doxorubicin treatment</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-08-22</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>31804</spage><epage>31804</epage><pages>31804-31804</pages><artnum>31804</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>We investigated gene expression profiles of the NF-κB pathway in patients with triple-negative breast cancer (TNBC) receiving adjuvant chemotherapy to determine the prognostic value of NF-κB pathway genes according to chemotherapeutic regimen. We used the nCounter expression assay to measure expression of 11 genes (NFKB1, NFKB2, RELA, RELB, REL, TP53, FOXC1, TBP, SP1, STAT3 and IRF1 genes) belonging to the NF-κB pathway using mRNA extracted from paraffin-embedded tumor tissues from 203 patients diagnosed with TNBC. Of the 203 patients, 116 were treated with a chemotherapeutic regimen containing doxorubicin. As revealed by the expression profiles of the 11 genes, increased expression of SP1 was associated with poor prognosis in TNBC patients treated with adjuvant doxorubicin chemotherapy (5-year distant recurrence-free survival [5Y DRFS], low vs. high expression [cut-off: median]: 92.3% vs. 71.6%,
P
= 0.001). In a multivariate Cox regression model, SP1 expression was a useful marker for predicting long-term prognosis in TNBC patients receiving doxorubicin treatment, and we thus suggest that SP1 expression could serve as a prognostic marker in these patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27545642</pmid><doi>10.1038/srep31804</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/4028/67/1347 692/4028/67/69 Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - genetics Chemotherapy, Adjuvant Combined Modality Therapy Doxorubicin - administration & dosage Female Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humanities and Social Sciences Humans Kaplan-Meier Estimate Middle Aged multidisciplinary NF-kappa B - genetics Prognosis Retrospective Studies Science Science (multidisciplinary) Signal Transduction - genetics Sp1 Transcription Factor - genetics Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - surgery Young Adult |
| title | The relationship between nuclear factor (NF)-κB family gene expression and prognosis in triple-negative breast cancer (TNBC) patients receiving adjuvant doxorubicin treatment |
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