mTOR Inhibition Suppresses Posttransplant Alloantibody Production Through Direct Inhibition of Alloprimed B Cells and Sparing of CD8+ Antibody-Suppressing T cells

BACKGROUNDDe novo alloantibodies (donor-specific antibody) contribute to antibody-mediated rejection and poor long-term graft survival. Because the development of donor-specific antibody is associated with early graft loss of cell transplants and reduced long-term survival of solid organ transplants...

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Veröffentlicht in:	Transplantation 2016-09, Vol.100 (9), p.1898-1906
Hauptverfasser:	Avila, Christina L, Zimmerer, Jason M, Elzein, Steven M, Pham, Thomas A, Abdel-Rasoul, Mahmoud, Bumgardner, Ginny L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - drug effects B-Lymphocytes - enzymology B-Lymphocytes - immunology Calcineurin Inhibitors - pharmacology CD8 Antigens - genetics CD8 Antigens - immunology CD8 Antigens - metabolism CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - immunology Cells, Cultured Coculture Techniques Cytotoxicity, Immunologic - drug effects Down-Regulation Genotype Graft Rejection - enzymology Graft Rejection - immunology Graft Rejection - prevention & control Graft Survival - drug effects Hepatocytes - immunology Hepatocytes - transplantation Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Immunity, Cellular - drug effects Immunity, Humoral - drug effects Immunosuppressive Agents - pharmacology Isoantibodies - blood Isoantibodies - immunology Liver Transplantation - adverse effects Liver Transplantation - methods Mice, Inbred C57BL Mice, Knockout Models, Animal Phenotype Protein Kinase Inhibitors - pharmacology Time Factors TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism
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