Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia
The aim of our study was to evaluate the relationship between neutrophil/lymphocyte ratio (NLR) and total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), paraoxonase, and total thiol (T.thl) in schizophrenic patients compared to healthy control group and investi...
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| Veröffentlicht in: | Neuropsychiatric disease and treatment 2016-01, Vol.12, p.1999-2005 |
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| description | The aim of our study was to evaluate the relationship between neutrophil/lymphocyte ratio (NLR) and total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), paraoxonase, and total thiol (T.thl) in schizophrenic patients compared to healthy control group and investigate the relationship between these parameters and psychopathological symptoms.
The study population consisted of 61 healthy control subjects and 64 volunteer patients monitored in the outpatient clinics of psychiatry of Antalya Education and Research Hospital. Hemograms were determined by using a fully automated hematology analyzer (Beckman Coulter LH780). Serum TOS, TAS, paraoxonase, and T.thl were measured using a novel automated colorimetric measurement method developed by Erel. Sociodemographic data forms were completed by the participants. The Positive and Negative Syndrome Scale (PANSS) was used to assess the patients.
Neutrophils, NLR, TAS, and TOS significantly increased, whereas lymphocytes, T.thl, and T.thl/OSI ratio were significantly lower in the schizophrenia patient group compared to the control group. A statistically significant positive relationship was found between PANSS positive subscale with leukocytes and significantly negative relationships were found between PANSS positive subscale with lymphocytes and T.thl/OSI ratio. Significant positive relationships were found between PANSS total subscale with leukocytes and NLR. Statistically significant negative relationships were found between PANSS total subscale with lymphocytes and T.thl/OSI ratio. In the group of patients with schizophrenia, a significant negative correlation was found between NLR with T.thl/OSI. In the group of patients with schizophrenia, a significant positive correlation was found between NLR with TOS and OSI.
By measuring NLR, which is simple, inexpensive, and suitable for routine use, we can obtain information about oxidative stress and psychopathological symptoms in patients with schizophrenia. Inflammation and oxidative stress are important in the pathogenesis of schizophrenia and are closely related with the patients' clinical symptoms. |
| doi_str_mv | 10.2147/NDT.S110484 |
| format | Article |
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The study population consisted of 61 healthy control subjects and 64 volunteer patients monitored in the outpatient clinics of psychiatry of Antalya Education and Research Hospital. Hemograms were determined by using a fully automated hematology analyzer (Beckman Coulter LH780). Serum TOS, TAS, paraoxonase, and T.thl were measured using a novel automated colorimetric measurement method developed by Erel. Sociodemographic data forms were completed by the participants. The Positive and Negative Syndrome Scale (PANSS) was used to assess the patients.
Neutrophils, NLR, TAS, and TOS significantly increased, whereas lymphocytes, T.thl, and T.thl/OSI ratio were significantly lower in the schizophrenia patient group compared to the control group. A statistically significant positive relationship was found between PANSS positive subscale with leukocytes and significantly negative relationships were found between PANSS positive subscale with lymphocytes and T.thl/OSI ratio. Significant positive relationships were found between PANSS total subscale with leukocytes and NLR. Statistically significant negative relationships were found between PANSS total subscale with lymphocytes and T.thl/OSI ratio. In the group of patients with schizophrenia, a significant negative correlation was found between NLR with T.thl/OSI. In the group of patients with schizophrenia, a significant positive correlation was found between NLR with TOS and OSI.
By measuring NLR, which is simple, inexpensive, and suitable for routine use, we can obtain information about oxidative stress and psychopathological symptoms in patients with schizophrenia. Inflammation and oxidative stress are important in the pathogenesis of schizophrenia and are closely related with the patients' clinical symptoms.</description><identifier>ISSN: 1176-6328</identifier><identifier>ISSN: 1178-2021</identifier><identifier>EISSN: 1178-2021</identifier><identifier>DOI: 10.2147/NDT.S110484</identifier><identifier>PMID: 27574431</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Antioxidants ; Antioxidants (Nutrients) ; Automation ; Cardiovascular disease ; Care and treatment ; Enzymes ; Health aspects ; Inflammation ; Lymphocytes ; Mental disorders ; Neutrophils ; Original Research ; Oxidative stress ; Physiological aspects ; Psychiatry ; Psychological aspects ; Psychopathology ; Schizophrenia ; Sociodemographics ; Statistical analysis ; Studies ; Thiols</subject><ispartof>Neuropsychiatric disease and treatment, 2016-01, Vol.12, p.1999-2005</ispartof><rights>COPYRIGHT 2016 Dove Medical Press Limited</rights><rights>2016. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Kulaksizoglu and Kulaksizoglu. This work is published and licensed by Dove Medical Press Limited 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-7716469060898844c5e59dcefda14c02c87bad313de03c5c505d434150843a5b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991539/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991539/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,3862,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27574431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kulaksizoglu, Burak</creatorcontrib><creatorcontrib>Kulaksizoglu, Sibel</creatorcontrib><title>Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia</title><title>Neuropsychiatric disease and treatment</title><addtitle>Neuropsychiatr Dis Treat</addtitle><description>The aim of our study was to evaluate the relationship between neutrophil/lymphocyte ratio (NLR) and total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), paraoxonase, and total thiol (T.thl) in schizophrenic patients compared to healthy control group and investigate the relationship between these parameters and psychopathological symptoms.
The study population consisted of 61 healthy control subjects and 64 volunteer patients monitored in the outpatient clinics of psychiatry of Antalya Education and Research Hospital. Hemograms were determined by using a fully automated hematology analyzer (Beckman Coulter LH780). Serum TOS, TAS, paraoxonase, and T.thl were measured using a novel automated colorimetric measurement method developed by Erel. Sociodemographic data forms were completed by the participants. The Positive and Negative Syndrome Scale (PANSS) was used to assess the patients.
Neutrophils, NLR, TAS, and TOS significantly increased, whereas lymphocytes, T.thl, and T.thl/OSI ratio were significantly lower in the schizophrenia patient group compared to the control group. A statistically significant positive relationship was found between PANSS positive subscale with leukocytes and significantly negative relationships were found between PANSS positive subscale with lymphocytes and T.thl/OSI ratio. Significant positive relationships were found between PANSS total subscale with leukocytes and NLR. Statistically significant negative relationships were found between PANSS total subscale with lymphocytes and T.thl/OSI ratio. In the group of patients with schizophrenia, a significant negative correlation was found between NLR with T.thl/OSI. In the group of patients with schizophrenia, a significant positive correlation was found between NLR with TOS and OSI.
By measuring NLR, which is simple, inexpensive, and suitable for routine use, we can obtain information about oxidative stress and psychopathological symptoms in patients with schizophrenia. Inflammation and oxidative stress are important in the pathogenesis of schizophrenia and are closely related with the patients' clinical symptoms.</description><subject>Antioxidants</subject><subject>Antioxidants (Nutrients)</subject><subject>Automation</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Enzymes</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Lymphocytes</subject><subject>Mental disorders</subject><subject>Neutrophils</subject><subject>Original Research</subject><subject>Oxidative stress</subject><subject>Physiological aspects</subject><subject>Psychiatry</subject><subject>Psychological aspects</subject><subject>Psychopathology</subject><subject>Schizophrenia</subject><subject>Sociodemographics</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Thiols</subject><issn>1176-6328</issn><issn>1178-2021</issn><issn>1178-2021</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkt1rFDEUxQdRbK0--S4Dgggy22SSTDIvQqlfhaKg9TlkM3d2UrLJmGRax7_ebHdtu-KD5CG5N79zuFxOUTzHaFFjyo8_v7tYfMMYUUEfFIcYc1HVqMYPb95N1ZBaHBRPYrxEiPBWiMfFQc0Zp5Tgw2L-ClYl410czFguIV0DuNLBlIIfB2OP7bweB6_nBGXYgOW1SUPpf5ouV1dQxhQgxlK5rhzjrAc_qjR461dzaVyZCwMuxa0q6sH8yrYBnFFPi0e9shGe7e6j4vuH9xenn6rzLx_PTk_OK80oShXnuKFNixok8uyUagas7TT0ncJUo1oLvlQdwaQDRDTTDLGOEooZEpQotiRHxdut7zgt15CVLgVl5RjMWoVZemXk_o8zg1z5K0nbFjPSZoPXO4Pgf0wQk1ybqMFa5cBPUWJRcyE4F-g_UMwaUWMiMvryL_TST8HlTci6poizBrfsjlopC9K43ucR9cZUnjDUNAxTtPFa_IPKp4O10d5Bb3J_T_DqnmAAZdMQvZ1ugrAPvtmCOvgYA_S3e8NIbtInc_rkLn2ZfnF_1bfsn7iR3xB81ZQ</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Kulaksizoglu, Burak</creator><creator>Kulaksizoglu, Sibel</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia</title><author>Kulaksizoglu, Burak ; 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The study population consisted of 61 healthy control subjects and 64 volunteer patients monitored in the outpatient clinics of psychiatry of Antalya Education and Research Hospital. Hemograms were determined by using a fully automated hematology analyzer (Beckman Coulter LH780). Serum TOS, TAS, paraoxonase, and T.thl were measured using a novel automated colorimetric measurement method developed by Erel. Sociodemographic data forms were completed by the participants. The Positive and Negative Syndrome Scale (PANSS) was used to assess the patients.
Neutrophils, NLR, TAS, and TOS significantly increased, whereas lymphocytes, T.thl, and T.thl/OSI ratio were significantly lower in the schizophrenia patient group compared to the control group. A statistically significant positive relationship was found between PANSS positive subscale with leukocytes and significantly negative relationships were found between PANSS positive subscale with lymphocytes and T.thl/OSI ratio. Significant positive relationships were found between PANSS total subscale with leukocytes and NLR. Statistically significant negative relationships were found between PANSS total subscale with lymphocytes and T.thl/OSI ratio. In the group of patients with schizophrenia, a significant negative correlation was found between NLR with T.thl/OSI. In the group of patients with schizophrenia, a significant positive correlation was found between NLR with TOS and OSI.
By measuring NLR, which is simple, inexpensive, and suitable for routine use, we can obtain information about oxidative stress and psychopathological symptoms in patients with schizophrenia. Inflammation and oxidative stress are important in the pathogenesis of schizophrenia and are closely related with the patients' clinical symptoms.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>27574431</pmid><doi>10.2147/NDT.S110484</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; DOVE Medical Press Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Antioxidants Antioxidants (Nutrients) Automation Cardiovascular disease Care and treatment Enzymes Health aspects Inflammation Lymphocytes Mental disorders Neutrophils Original Research Oxidative stress Physiological aspects Psychiatry Psychological aspects Psychopathology Schizophrenia Sociodemographics Statistical analysis Studies Thiols |
| title | Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia |
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