Glucocorticoid-Suppressible Hyperaldosteronism Results from Hybrid Genes Created by Unequal Crossovers between CYP11B1 and CYP11B2

Glucocorticoid-suppressible hyperaldosteronism (GSH) is an autosomal dominant form of familial hypertension. The biochemical abnormalities seen in this disorder may be remedied by administration of dexamethasone, implying that aldosterone synthesis is being abnormally regulated by corticotropin. The...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-09, Vol.89 (17), p.8327-8331
Hauptverfasser:	Pascoe, Leigh, Curnow, Kathleen M., Slutsker, Liliya, John M. C. Connell, Speiser, Phyllis W., New, Maria I., White, Perrin C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal cortex aldosterone Blotting, Southern Chromosomes Chromosomes, Human, Pair 8 Complementary DNA Corticosterone COS cells Crossovers CYP11B1 gene CYP11B2 gene Cytochrome P-450 CYP11B2 Cytochrome P-450 Enzyme System - genetics cytochrome P450 DNA Exons Gene Conversion Gene Rearrangement Genes glucocorticoids Glucocorticoids - pharmacology Humans Hybridity hybrids hyperaldosteronism Hyperaldosteronism - genetics man Recombination, Genetic Steroid 11-beta-Hydroxylase - genetics Steroid Hydroxylases - genetics suppression
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