A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines

An activity-based proteomic strategy identifies PLA2G4E as the calcium-dependent N-acyltransferase that generates an unusual triacylated class of lipids, the NAPEs, which are precursors to bioactive lipids including the endogenous cannabinoid anandamide. More than 30 years ago, a calcium-dependent e...

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Veröffentlicht in:	Nature chemical biology 2016-09, Vol.12 (9), p.669-671
Hauptverfasser:	Ogura, Yuji, Parsons, William H, Kamat, Siddhesh S, Cravatt, Benjamin F
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/287/1194 631/92/607 82 82/58 82/83 Acyltransferases - chemistry Acyltransferases - metabolism Animals Biochemical Engineering Biochemistry Bioorganic Chemistry brief-communication Calcium Calcium - metabolism Calcium phosphates Cell Biology Chemistry Chemistry/Food Science Enzymatic activity Enzymes Lipids Male Mammals Mice Mice, Inbred C57BL Molecular Structure Phosphatidylethanolamines - biosynthesis Phosphatidylethanolamines - chemistry
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