An evolutionarily conserved pathway controls proteasome homeostasis

Proteasome abundance is crucial for cell survival, but how cells maintain adequate amounts of proteasome is unclear; an analysis in yeast identifies TORC1 and Mpk1 as central components of a pathway regulating proteasome homeostasis through the coordinated regulation of regulatory particle assembly...

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Veröffentlicht in:	Nature (London) 2016-08, Vol.536 (7615), p.184-189
Hauptverfasser:	Rousseau, Adrien, Bertolotti, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/89 13/95 14/19 38/77 42/35 631/80/474/1768 631/80/474/2085 631/80/86/2366 82/29 Animals Cell Survival Cells Conserved Sequence Evolution, Molecular HeLa Cells Homeostasis Humanities and Social Sciences Humans Kinases Mammals Mitogen-Activated Protein Kinase 7 - metabolism Mitogen-Activated Protein Kinases - metabolism Molecular Chaperones - metabolism multidisciplinary Physiological aspects Proteasome Endopeptidase Complex - chemistry Proteasome Endopeptidase Complex - metabolism Protein research Protein Subunits - metabolism Proteins Proteolysis Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - metabolism Science Signal Transduction Stress, Physiological TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Transcription Factors - antagonists & inhibitors Transcription Factors - metabolism Ubiquitin-proteasome system Yeasts
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