HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy
This study is to prepare a hematoporphyrin monomethyl ether (HMME)-loaded poly(lactic-co-glycolic acid) (PLGA) microcapsules (HMME/PLGA), which could not only function as efficient contrast agent for ultrasound (US)/photoacoustic (PA) imaging, but also as a synergistic agent for high intensity focus...
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| Veröffentlicht in: | Scientific reports 2016-08, Vol.6 (1), p.31833-31833, Article 31833 |
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| creator | Yan, Sijing LU, Min Ding, Xiaoya Chen, Fei He, Xuemei Xu, Chunyan Zhou, Hang Wang, Qi Hao, Lan Zou, Jianzhong |
| description | This study is to prepare a hematoporphyrin monomethyl ether (HMME)-loaded poly(lactic-co-glycolic acid) (PLGA) microcapsules (HMME/PLGA), which could not only function as efficient contrast agent for ultrasound (US)/photoacoustic (PA) imaging, but also as a synergistic agent for high intensity focused ultrasound (HIFU) ablation. Sonosensitizer HMME nanoparticles were integrated into PLGA microcapsules with the double emulsion evaporation method. After characterization, the cell-killing and cell proliferation-inhibiting effects of HMME/PLGA microcapsules on ovarian cancer SKOV
3
cells were assessed. The US/PA imaging-enhancing effects and synergistic effects on HIFU were evaluated both
in vitro
and
in vivo
. HMME/PLGA microcapsules were highly dispersed with well-defined spherical morphology (357 ± 0.72 nm in diameter, PDI = 0.932). Encapsulation efficiency and drug-loading efficiency were 58.33 ± 0.95% and 4.73 ± 0.15%, respectively. The HMME/PLGA microcapsules remarkably killed the SKOV
3
cells and inhibited the cell proliferation, significantly enhanced the US/PA imaging results and greatly enhanced the HIFU ablation effects on ovarian cancer in nude mice by the HMME-mediated sono-dynamic chemistry therapy (SDT). HMME/PLGA microcapsules represent a potential multifunctional contrast agent for HIFU diagnosis and treatment, which might provide a novel strategy for the highly efficient imaging-guided non-invasive HIFU synergistic therapy for cancers by SDT in clinic. |
| doi_str_mv | 10.1038/srep31833 |
| format | Article |
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3
cells were assessed. The US/PA imaging-enhancing effects and synergistic effects on HIFU were evaluated both
in vitro
and
in vivo
. HMME/PLGA microcapsules were highly dispersed with well-defined spherical morphology (357 ± 0.72 nm in diameter, PDI = 0.932). Encapsulation efficiency and drug-loading efficiency were 58.33 ± 0.95% and 4.73 ± 0.15%, respectively. The HMME/PLGA microcapsules remarkably killed the SKOV
3
cells and inhibited the cell proliferation, significantly enhanced the US/PA imaging results and greatly enhanced the HIFU ablation effects on ovarian cancer in nude mice by the HMME-mediated sono-dynamic chemistry therapy (SDT). HMME/PLGA microcapsules represent a potential multifunctional contrast agent for HIFU diagnosis and treatment, which might provide a novel strategy for the highly efficient imaging-guided non-invasive HIFU synergistic therapy for cancers by SDT in clinic.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep31833</identifier><identifier>PMID: 27535093</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14 ; 140/125 ; 631/67/2321 ; 639/301/357/354 ; Animals ; Cell growth ; Cell Line, Tumor ; Cell proliferation ; Contrast agents ; Contrast Media - chemistry ; Contrast Media - pharmacokinetics ; Contrast Media - pharmacology ; Encapsulation ; Evaporation ; Extracorporeal Shockwave Therapy - methods ; Female ; Glycolic acid ; Hematoporphyrins - chemistry ; Hematoporphyrins - pharmacokinetics ; Hematoporphyrins - pharmacology ; Humanities and Social Sciences ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Microcapsules ; multidisciplinary ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; Ovarian cancer ; Ovarian Neoplasms - diagnostic imaging ; Ovarian Neoplasms - therapy ; Photoacoustic Techniques - methods ; Polylactide-co-glycolide ; Polymers ; Science ; Science (multidisciplinary) ; Synergistic effect ; Ultrasonic imaging ; Ultrasonography - methods ; Ultrasound ; Xenograft Model Antitumor Assays</subject><ispartof>Scientific reports, 2016-08, Vol.6 (1), p.31833-31833, Article 31833</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Aug 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-d022beb9cd8ddbc1a62f8da43f94aa88870f8663e80fad597c53727f416176293</citedby><cites>FETCH-LOGICAL-c438t-d022beb9cd8ddbc1a62f8da43f94aa88870f8663e80fad597c53727f416176293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989155/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989155/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27535093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Sijing</creatorcontrib><creatorcontrib>LU, Min</creatorcontrib><creatorcontrib>Ding, Xiaoya</creatorcontrib><creatorcontrib>Chen, Fei</creatorcontrib><creatorcontrib>He, Xuemei</creatorcontrib><creatorcontrib>Xu, Chunyan</creatorcontrib><creatorcontrib>Zhou, Hang</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Hao, Lan</creatorcontrib><creatorcontrib>Zou, Jianzhong</creatorcontrib><title>HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>This study is to prepare a hematoporphyrin monomethyl ether (HMME)-loaded poly(lactic-co-glycolic acid) (PLGA) microcapsules (HMME/PLGA), which could not only function as efficient contrast agent for ultrasound (US)/photoacoustic (PA) imaging, but also as a synergistic agent for high intensity focused ultrasound (HIFU) ablation. Sonosensitizer HMME nanoparticles were integrated into PLGA microcapsules with the double emulsion evaporation method. After characterization, the cell-killing and cell proliferation-inhibiting effects of HMME/PLGA microcapsules on ovarian cancer SKOV
3
cells were assessed. The US/PA imaging-enhancing effects and synergistic effects on HIFU were evaluated both
in vitro
and
in vivo
. HMME/PLGA microcapsules were highly dispersed with well-defined spherical morphology (357 ± 0.72 nm in diameter, PDI = 0.932). Encapsulation efficiency and drug-loading efficiency were 58.33 ± 0.95% and 4.73 ± 0.15%, respectively. The HMME/PLGA microcapsules remarkably killed the SKOV
3
cells and inhibited the cell proliferation, significantly enhanced the US/PA imaging results and greatly enhanced the HIFU ablation effects on ovarian cancer in nude mice by the HMME-mediated sono-dynamic chemistry therapy (SDT). HMME/PLGA microcapsules represent a potential multifunctional contrast agent for HIFU diagnosis and treatment, which might provide a novel strategy for the highly efficient imaging-guided non-invasive HIFU synergistic therapy for cancers by SDT in clinic.</description><subject>14</subject><subject>140/125</subject><subject>631/67/2321</subject><subject>639/301/357/354</subject><subject>Animals</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Contrast agents</subject><subject>Contrast Media - chemistry</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Contrast Media - pharmacology</subject><subject>Encapsulation</subject><subject>Evaporation</subject><subject>Extracorporeal Shockwave Therapy - methods</subject><subject>Female</subject><subject>Glycolic acid</subject><subject>Hematoporphyrins - chemistry</subject><subject>Hematoporphyrins - pharmacokinetics</subject><subject>Hematoporphyrins - pharmacology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Microcapsules</subject><subject>multidisciplinary</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - therapeutic use</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - diagnostic imaging</subject><subject>Ovarian Neoplasms - therapy</subject><subject>Photoacoustic Techniques - methods</subject><subject>Polylactide-co-glycolide</subject><subject>Polymers</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Synergistic effect</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography - methods</subject><subject>Ultrasound</subject><subject>Xenograft Model Antitumor Assays</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkk1v1DAQhi0EotXSA38AWeLSIoX6Ix_2BamqWrZSERzo2fLaTuIqsYPtIOVP8Rtx2LIs4MtYnkfvvOMZAF5j9B4jyi5jMBPFjNJn4JSgsioIJeT50f0EnMX4iPKpCC8xfwlOSFPRCnF6Cn5szSiT_-LD1C_BOvjJOz-a1C8DvEm9CXDywzLmqLxLQcYEZWdcgq0PcB7WFz87fTn1Pnmp_ByTVVDPcihGr-Vg0wLtKDvruqKbrTYaxsWZ0NlfYG-7HlqXjIsr2Xo1x4z8EYbn27vbhwu4WpHT8gq8aOUQzdlT3ICH25uv19vi_vPHu-ur-0KVlKVCI0J2ZseVZlrvFJY1aZmWJW15KSVjrEEtq2tqGGqlrnijKtqQpi1xjZuacLoBH_a607wbjVZm7X0QU8i9hEV4acXfGWd70fnvouSM46rKAudPAsF_m01MYrRRmWGQzuRPEphhkn2sJjbg7T_oo5-Dy-0JzBGlDCO8OrrYUyr4mGfeHsxgJNZFEIdFyOybY_cH8vfYM_BuD8Sccp0JRyX_U_sJFavC8g</recordid><startdate>20160818</startdate><enddate>20160818</enddate><creator>Yan, Sijing</creator><creator>LU, Min</creator><creator>Ding, Xiaoya</creator><creator>Chen, Fei</creator><creator>He, Xuemei</creator><creator>Xu, Chunyan</creator><creator>Zhou, Hang</creator><creator>Wang, Qi</creator><creator>Hao, Lan</creator><creator>Zou, Jianzhong</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160818</creationdate><title>HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy</title><author>Yan, Sijing ; LU, Min ; Ding, Xiaoya ; Chen, Fei ; He, Xuemei ; Xu, Chunyan ; Zhou, Hang ; Wang, Qi ; Hao, Lan ; Zou, Jianzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-d022beb9cd8ddbc1a62f8da43f94aa88870f8663e80fad597c53727f416176293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>14</topic><topic>140/125</topic><topic>631/67/2321</topic><topic>639/301/357/354</topic><topic>Animals</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell proliferation</topic><topic>Contrast agents</topic><topic>Contrast Media - chemistry</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Contrast Media - pharmacology</topic><topic>Encapsulation</topic><topic>Evaporation</topic><topic>Extracorporeal Shockwave Therapy - methods</topic><topic>Female</topic><topic>Glycolic acid</topic><topic>Hematoporphyrins - chemistry</topic><topic>Hematoporphyrins - pharmacokinetics</topic><topic>Hematoporphyrins - pharmacology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Microcapsules</topic><topic>multidisciplinary</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - therapeutic use</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - diagnostic imaging</topic><topic>Ovarian Neoplasms - therapy</topic><topic>Photoacoustic Techniques - methods</topic><topic>Polylactide-co-glycolide</topic><topic>Polymers</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Synergistic effect</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography - methods</topic><topic>Ultrasound</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Sijing</creatorcontrib><creatorcontrib>LU, Min</creatorcontrib><creatorcontrib>Ding, Xiaoya</creatorcontrib><creatorcontrib>Chen, Fei</creatorcontrib><creatorcontrib>He, Xuemei</creatorcontrib><creatorcontrib>Xu, Chunyan</creatorcontrib><creatorcontrib>Zhou, Hang</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Hao, Lan</creatorcontrib><creatorcontrib>Zou, Jianzhong</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Sijing</au><au>LU, Min</au><au>Ding, Xiaoya</au><au>Chen, Fei</au><au>He, Xuemei</au><au>Xu, Chunyan</au><au>Zhou, Hang</au><au>Wang, Qi</au><au>Hao, Lan</au><au>Zou, Jianzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-08-18</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>31833</spage><epage>31833</epage><pages>31833-31833</pages><artnum>31833</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>This study is to prepare a hematoporphyrin monomethyl ether (HMME)-loaded poly(lactic-co-glycolic acid) (PLGA) microcapsules (HMME/PLGA), which could not only function as efficient contrast agent for ultrasound (US)/photoacoustic (PA) imaging, but also as a synergistic agent for high intensity focused ultrasound (HIFU) ablation. Sonosensitizer HMME nanoparticles were integrated into PLGA microcapsules with the double emulsion evaporation method. After characterization, the cell-killing and cell proliferation-inhibiting effects of HMME/PLGA microcapsules on ovarian cancer SKOV
3
cells were assessed. The US/PA imaging-enhancing effects and synergistic effects on HIFU were evaluated both
in vitro
and
in vivo
. HMME/PLGA microcapsules were highly dispersed with well-defined spherical morphology (357 ± 0.72 nm in diameter, PDI = 0.932). Encapsulation efficiency and drug-loading efficiency were 58.33 ± 0.95% and 4.73 ± 0.15%, respectively. The HMME/PLGA microcapsules remarkably killed the SKOV
3
cells and inhibited the cell proliferation, significantly enhanced the US/PA imaging results and greatly enhanced the HIFU ablation effects on ovarian cancer in nude mice by the HMME-mediated sono-dynamic chemistry therapy (SDT). HMME/PLGA microcapsules represent a potential multifunctional contrast agent for HIFU diagnosis and treatment, which might provide a novel strategy for the highly efficient imaging-guided non-invasive HIFU synergistic therapy for cancers by SDT in clinic.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27535093</pmid><doi>10.1038/srep31833</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 14 140/125 631/67/2321 639/301/357/354 Animals Cell growth Cell Line, Tumor Cell proliferation Contrast agents Contrast Media - chemistry Contrast Media - pharmacokinetics Contrast Media - pharmacology Encapsulation Evaporation Extracorporeal Shockwave Therapy - methods Female Glycolic acid Hematoporphyrins - chemistry Hematoporphyrins - pharmacokinetics Hematoporphyrins - pharmacology Humanities and Social Sciences Humans Mice Mice, Inbred BALB C Mice, Nude Microcapsules multidisciplinary Nanoparticles Nanoparticles - chemistry Nanoparticles - therapeutic use Ovarian cancer Ovarian Neoplasms - diagnostic imaging Ovarian Neoplasms - therapy Photoacoustic Techniques - methods Polylactide-co-glycolide Polymers Science Science (multidisciplinary) Synergistic effect Ultrasonic imaging Ultrasonography - methods Ultrasound Xenograft Model Antitumor Assays |
| title | HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy |
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