Dysregulation of Neuronal Ca2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive States

Hypertension is associated with impaired nitric oxide (NO)-cyclic nucleotide (CN)-coupled intracellular calcium (Ca(2+)) homeostasis that enhances cardiac sympathetic neurotransmission. Because neuronal membrane Ca(2+) currents are reduced by NO-activated S-nitrosylation, we tested whether CNs affec...

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Veröffentlicht in:	The Journal of neuroscience 2016-08, Vol.36 (33), p.8562-8573
Hauptverfasser:	Larsen, Hege E, Bardsley, Emma N, Lefkimmiatis, Konstantinos, Paterson, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channel Blockers - pharmacology Calcium Channels - metabolism Cells, Cultured Cyclic AMP - metabolism Cyclic GMP - metabolism Disease Models, Animal Enzyme Inhibitors - pharmacology Hypertension - pathology Hypertension - physiopathology Male Membrane Potentials - drug effects Membrane Potentials - genetics Neurons - drug effects Neurons - physiology Phenotype Protein Kinase C - metabolism Protein Kinases Rats Rats, Inbred SHR Rats, Inbred WKY Rats, Wistar Sympathetic Nervous System - physiopathology Tyrosine 3-Monooxygenase - metabolism
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